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CAS No. : | 936940-09-9 | MDL No. : | MFCD08700560 |
Formula : | C7H13N3 | Boiling Point : | No data available |
Linear Structure Formula : | - | InChI Key : | VMNKYEWGKWZUNI-UHFFFAOYSA-N |
M.W : | 139.20 | Pubchem ID : | 23005591 |
Synonyms : |
|
Signal Word: | Warning | Class: | |
Precautionary Statements: | P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313-P362 | UN#: | |
Hazard Statements: | H315-H319 | Packing Group: | |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
60% | With triethylamine; HATU; In dichloromethane; | A solution of 4-methyl-3 - ((4-methylphenyl) sulfonyl) benzoic acid (0.153g, 0.5mmol), (1- isopropyl -1H- pyrazol-4-yl) methanamine ( A reaction mixture of 0.070 g, 0.5 mmol), HATU (0.228 g, 0.6 mmol) and triethylamine (0.152 g, 1.5 mmol) in DCM (10 mL) was stirred overnight.Water (50 mL) was added, and the resulting mixture was extracted with DCM (30 mL×3). The combined organic layer was washed with water (30mL×2) and brine (30mL), dried over anhydrous sodium sulfate, filtered,concentrate. The residue was purified by preparative thin layer chromatography (silica gel, DCM/MeOH=15:1) to obtain the product as a white solid (127 mg, yield 60%). |
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