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5-chloro-6-ethyl-3-[3-fluoro-4-(morpholin-4-yl)phenyl]amino}pyrazine-2-carboxamide[ No CAS ]
Yield
Reaction Conditions
Operation in experiment
640 mg
With N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; at 180℃; for 1h;Microwave irradiation;
Preparation Example 256 A mixture of <strong>[313340-08-8]3,5-dichloro-6-ethylpyrazine-2-carboxamide</strong> (600 mg), 3-fluoro-4-(morpholin-4-yl)aniline (500 mg), diisopropylethylamine (880 muL), and N-methylpyrrolidone (2.5 mL) was reacted in a microwave reaction device at 180 C. for 1 hour. After leaving to be cooled, to the reactant was added water, and the precipitated solid was collected by filtration and then washed with ethanol to obtain 5-chloro-6-ethyl-3-[3-fluoro-4-(morpholin-4-yl)phenyl]amino}pyrazine-2-carboxamide (640 mg) as a yellow solid.
Add in a 100mL three-necked flask1.87g (5mmo1) <strong>[2631-77-8]3,5-diiodosalicylaldehyde</strong> and 0.98g (5mmol) of 3-fluoro-4-morpholinylaniline dissolved in 15mL of absolute ethanol, stirred at room temperature for 40min; cooled, precipitated solid, filtered Washed with ethanol and dried to give a red blood solid 2.45 g.That is, bisiodosalicylidene 3-fluoro-4-morpholinylaniline Schiff base. Yield: 89%; m.p.: 181-183 C.
Chemistry
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Material Science
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120K+ Compounds
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