天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

Home Cart 0 Sign in  

[ CAS No. 932-30-9 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
Chemical Structure| 932-30-9
Chemical Structure| 932-30-9
Structure of 932-30-9 * Storage: {[proInfo.prStorage]}

Please Login or Create an Account to: See VIP prices and availability

Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Search after Editing

* Storage: {[proInfo.prStorage]}

* Shipping: {[proInfo.prShipping]}

Quality Control of [ 932-30-9 ]

Related Doc. of [ 932-30-9 ]

Alternatived Products of [ 932-30-9 ]
Product Citations

Product Details of [ 932-30-9 ]

CAS No. :932-30-9 MDL No. :MFCD00870498
Formula : C7H9NO Boiling Point : -
Linear Structure Formula :- InChI Key :KPRZOPQOBJRYSW-UHFFFAOYSA-N
M.W : 123.15 Pubchem ID :70267
Synonyms :
2-Hydroxybenzylamine;o-Hydroxybenzylamine;NSC 127870;2-HOBA

Calculated chemistry of [ 932-30-9 ]      Expand+

Physicochemical Properties

Num. heavy atoms : 9
Num. arom. heavy atoms : 6
Fraction Csp3 : 0.14
Num. rotatable bonds : 1
Num. H-bond acceptors : 2.0
Num. H-bond donors : 2.0
Molar Refractivity : 36.14
TPSA : 46.25 ?2

Pharmacokinetics

GI absorption : High
BBB permeant : Yes
P-gp substrate : No
CYP1A2 inhibitor : No
CYP2C19 inhibitor : No
CYP2C9 inhibitor : No
CYP2D6 inhibitor : No
CYP3A4 inhibitor : Yes
Log Kp (skin permeation) : -6.72 cm/s

Lipophilicity

Log Po/w (iLOGP) : 1.03
Log Po/w (XLOGP3) : 0.47
Log Po/w (WLOGP) : 0.7
Log Po/w (MLOGP) : 0.88
Log Po/w (SILICOS-IT) : 0.98
Consensus Log Po/w : 0.81

Druglikeness

Lipinski : 0.0
Ghose : None
Veber : 0.0
Egan : 0.0
Muegge : 1.0
Bioavailability Score : 0.55

Water Solubility

Log S (ESOL) : -1.33
Solubility : 5.8 mg/ml ; 0.0471 mol/l
Class : Very soluble
Log S (Ali) : -1.01
Solubility : 12.0 mg/ml ; 0.0977 mol/l
Class : Very soluble
Log S (SILICOS-IT) : -1.82
Solubility : 1.86 mg/ml ; 0.0151 mol/l
Class : Soluble

Medicinal Chemistry

PAINS : 1.0 alert
Brenk : 0.0 alert
Leadlikeness : 1.0
Synthetic accessibility : 1.0

Safety of [ 932-30-9 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 932-30-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 932-30-9 ]

[ 932-30-9 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 932-30-9 ]
  • [ 112811-71-9 ]
  • C23H23FN2O5 [ No CAS ]
YieldReaction ConditionsOperation in experiment
In acetonitrile; at 120℃; for 6h; Three-necked flask was charged with 100 g of ethyl 1-cyclopropyl-6,7-difluoro-8-methoxy-1,4-dihydro-4-oxo-3-quinolinecarboxylate,Adding 600mL of acetonitrile, stirring, adding 2-hydroxybenzylamine 37mL, heating to 120 C for 6h, cooling, pouring the reaction solution into 1mol / L dilute hydrochloric acid, stirring, adding 500mLEA extraction,The aqueous phase was extracted with EA 300 mL × 2 and the organic layers were combined, dried and evaporated to dryness to give 92.3 g of the yellow product which was used in the next step without further purification.
  • 2
  • [ 1206675-01-5 ]
  • [ 932-30-9 ]
  • 3
  • [ 932-30-9 ]
  • [ 64-19-7 ]
  • [ 1206675-01-5 ]
YieldReaction ConditionsOperation in experiment
35.4 g 9. The dried solid was dissolved in 420 g of glacial acetic acid and stirred for 16-24 hours.10. To the reaction system, 932 g of methyl tert-butyl ether was added, and the mixture was stirred and crystallized at 0 to 10 C for 4 to 6 hours.11. Centrifuge the system, centrifuge the solids with 250 ml of 85% ethanol and centrifuge again.12. Centrifuge the solid at 40-50 C to dry, to obtain the final product 35.4g, white.
Recommend Products
Same Skeleton Products

Technical Information

Historical Records
; ;