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CAS No. : | 93107-30-3 | MDL No. : | MFCD01646375 |
Formula : | C13H9F2NO3 | Boiling Point : | No data available |
Linear Structure Formula : | - | InChI Key : | KNEXGVPHPGXAGF-UHFFFAOYSA-N |
M.W : | 265.21 | Pubchem ID : | 5210422 |
Synonyms : |
|
Signal Word: | Warning | Class: | |
Precautionary Statements: | P261-P280-P305+P351+P338 | UN#: | |
Hazard Statements: | H302-H315-H319-H332-H335 | Packing Group: | |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; | EXAMPLE 1 1-cyclopropyl-6-fluoro-1,4-dihydro-7-[1'-azetidinyl]-4-oxo-3-quinoline-carboxylic acid A mixture of 1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid (1.591 g, 6 mmole), acetonitrile (70 ml), azetidine (390 mg, 6.8 mmole) and DBU (913 mg, 6 mmole) were heated at reflux. After only 5 minutes of heating, it was observed that crystalline material was precipitating. After 5 additional minutes of heating, the hot solution was filtered. The reaction mixture was then allowed to cool at room temperature for 1 hour. The solid material that precipitated was collected by filtration, washed first with acetonitrile and then with ethyl ether and then dried to give 650 mg of the title compound, m.p. 298°-299° C. (dec.). NMR(DMSO-D6): 1.12-1.13 d and 1.26-1.28 d, 4H of cyclopropane; 2.3-2.4, m, 2H of C3 'azetidine; 3.2-3.7, q, 1H of cyclopropane; 4.19-4.24, q, 4H of azetidine C2 ' and C4 '; 6.82- 6.85, d, 1H of C8; 7.74-7.78, d, 1H of C5; 8.55, s, 1H of C2. |
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