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N-(1-carbamoyl-1,2-dimethylpropyl)-2-quinolinecarboxamide[ No CAS ]
Yield
Reaction Conditions
Operation in experiment
With triethylamine; In tetrahydrofuran; water;
EXAMPLE 55 Preparation of N-(1-carbamoyl-1,2-dimethylpropyl)quinaldamide STR203 To a solution of quinaldic acid (20 g, 0.116 mol) in tetrahydrofuran (500 ml) cooled to -9 C. is added methyl chloroformate (8.92 ml, 0.116 mol) followed by triethylamine (18.4 ml, 0.139 mol). After 20 minutes <strong>[40963-14-2]2-amino-2,3-dimethylbutyramide</strong> (15.1 g, 0.116 mol) is added and the mixture stirred overnight at room temperature. Water is added and the solution is reduced to 200 ml of a rotorvap. A white solid separates and is filtered off, water washed and dried. Recrystallization from absolute ethanol gives the product mp 179-180 C., 26.86 g (87%). Anal. calcd. for C16 H19 N3 O2: C, 67.34; H, 6.73; N, 14.72. Found: C, 67.14; H, 6.17; N, 14.72.
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