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CAS No. : | 88738-86-7 | MDL No. : | MFCD02684186 |
Formula : | C11H11BrO2 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | ZSRCGGBALFGALF-VOTSOKGWSA-N |
M.W : | 255.11 | Pubchem ID : | 11658908 |
Synonyms : |
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Signal Word: | Warning | Class: | |
Precautionary Statements: | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 | UN#: | |
Hazard Statements: | H315-H319 | Packing Group: | |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
87% | With potassium carbonate; In N,N-dimethyl-formamide; at 20℃; for 3h; | In a single-mouth round bottom flask,2-cyano-5-fluoro-phenol (0.68 g, 5 mmol) was dissolved in 25 ml of dry DMF.Potassium carbonate (1.38 g, 10 mmol) was added.Stir at room temperature and add (E)-4-bromomethyl benzoate (1.27 g, 5 mmol).Stirring reaction was continued for 3 h, and the reaction was complete by TLC.Quenched with water, extracted with ethyl acetate (3×30 mL).Dry over anhydrous sodium sulfate and remove the solvent under reduced pressure.Petroleum ether / dichloromethane = 1/2 elution,The white solid product was obtained in 1.36 g (yield: 87%). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
84% | With potassium carbonate; In N,N-dimethyl-formamide; at 20℃; for 3h; | In a one-neck round flask, 5-fluoro-2-methoxy - phenol (728mg, 5.13mmol) dissolved in 6ml of DMF dry,Potassium carbonate (1.42 g, 10.3 mmol) was added.Stir at room temperature and add (E)-4-bromomethyl benzoate (1.31 g, 5.13 mmol).Stirring reaction was continued for 3 h, and the reaction was complete by TLC.Quenched with water, extracted with ethyl acetate (3×30 mL).Dry over anhydrous sodium sulfate and remove the solvent under reduced pressure.Petroleum ether / dichloromethane = 1 / 1 elution,The product was obtained as a colorless oil, 1.36 g (yield 84%). |