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With pyridinium chlorochromate; In dichloromethane; at 20℃;
B. lH-Pyrrolo[2,3-b]pyridine-5-carbaldehyde.; (1H-Pyrrolo[2,3- b]pyridin-5-yl)methanol (crude from previous reaction) was dissolved in anhydrous methylenechloride (50 mL). Pyridiniumchlorochromate (3.70 g, 17.0 mmol) was added to the solution and stirred at room temperature overnight. The reaction mixture was filtered through silica gel and washed with ethyl acetate. Organics were poured into water (150 mL), extracted with EtOAc (4x100 mL), combined organic layers were dried with sodium sulfate, and concentrated under reduced pressure to afford the title compound (0.72 g, 4.93 mmol, 87percent over 2 steps) as a white solid. MS (ESI) m/z 147.1 [M+ 1]+.
To the solution of lH-pyrrolo[2,3-b]pyridine-5-carbaldehyde (400 mg, 2.73 mmol, 1.0 eq) in MeOH (10 mL) was added sodium borohydride (208 mg, 5.46 mmol, 2.0 eq). The reaction was stirred for 1 h, and then purified via flash chromatography to afford (lH-pyrrolo[2,3-b]pyridin-5-yl)methanol as a white solid (310 mg, 76percent).
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