* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
With sodium hydroxide In water at 20 - 60℃; for 2 h;
Take 282g hydrochloric acid ozagrel monohydrate, add water 1270ml, heated to 60 , dissolved completely, add 1mol / L sodium hydroxide solution 1000ml, cooled to 20 , put it aside for 2 hours, filter, filter cake washed dry Was added to a mixed solution of 300 ml of methanol / 900 ml of purified water, heated to complete dissolution, cooled to 5 ° C, incubated for 4 h, filtered and dried at 50 ° C to obtain 194.3 g of ozagrel.Ozagrel HPLC purity is shown in Fig.
Reference：
[1] Patent: CN106380448, 2017, A, . Location in patent: Paragraph 0046; 0047; 0048; 0049; 0050; 0051; 0052; 0053
2
[ 78712-80-8 ]
[ 82571-53-7 ]
Reference：
[1] Journal of Medicinal Chemistry, 1981, vol. 24, # 10, p. 1139 - 1148
3
[ 78712-67-1 ]
[ 82571-53-7 ]
Reference：
[1] Journal of Medicinal Chemistry, 1981, vol. 24, # 10, p. 1139 - 1148
4
[ 143945-86-2 ]
[ 82571-53-7 ]
Reference：
[1] Journal of Pharmaceutical Sciences, 1992, vol. 81, # 8, p. 817 - 822
With sodium hydroxide; In water; at 20 - 60℃; for 2.0h;
Take 282g hydrochloric acid <strong>[78712-43-3]ozagrel</strong> monohydrate, add water 1270ml, heated to 60 , dissolved completely, add 1mol / L sodium hydroxide solution 1000ml, cooled to 20 , put it aside for 2 hours, filter, filter cake washed dry Was added to a mixed solution of 300 ml of methanol / 900 ml of purified water, heated to complete dissolution, cooled to 5 C, incubated for 4 h, filtered and dried at 50 C to obtain 194.3 g of <strong>[78712-43-3]ozagrel</strong>.Ozagrel HPLC purity is shown in Fig.
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