天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

Home Cart 0 Sign in  

[ CAS No. 824-80-6 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
Chemical Structure| 824-80-6
Chemical Structure| 824-80-6
Structure of 824-80-6 * Storage: {[proInfo.prStorage]}

Please Login or Create an Account to: See VIP prices and availability

Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Search after Editing

* Storage: {[proInfo.prStorage]}

* Shipping: {[proInfo.prShipping]}

Quality Control of [ 824-80-6 ]

Related Doc. of [ 824-80-6 ]

Alternatived Products of [ 824-80-6 ]
Product Citations

Product Citations

Lotfipour, Farideh ; Nematollahi, Davood ; Mohamadighader, Niloofar , et al. DOI:

Abstract: This work is focused on the electrochemical late-stage modification of hydralazine (1-hydrazinylphthalazine) (HYD), a common antihypertensive drug, and the synthesis of its new sulfonylhydrazine derivatives. The synthesis of HYD derivatives has been easily accomplished in one-pot via electrochemical oxidation of HYD in the presence of arylsulfinic acid derivatives (ASA) in a water/ethanol mixture at constant current conditions. The electrochemical results show that anodically generated 1-diazenylphthalazine (HYDox) reacts with arylsulfinic acids and converts into the corresponding sulfonylhydrazine derivatives (SHD) with high yield and purity in an undivided cell equipped with graphite anode and stainless steel cathode. The main feature of this work is the synthesis of some new HYD derivatives in water/ethanol mixture as a “Green” reaction medium, using electrodes instead of toxic oxidants, having a high atom economy, having good energy efficiency and working at room temperature. These features are in accordance with the principles of green chemistry. Another advantage of this approach is that this method has led to the synthesis of sulfonylhydrazine derivatives in nano dimensions. Also, in this work, the electrochemical behavior of HYD and synthesized compounds (SHD) by different electrochemical methods were fully investigated and the results were reported. Furthermore, docking studies suggest that the products interact well with arylamine N-acetyltransferase (NAT) and show promising activity.

Keywords: Hydralazine ; Sulfonylhydrazine ; Late-stage modification ; Electrochemical synthesis ; Cyclic voltammetry ; Docking studies ; Nano-structured

Purchased from AmBeed:

Product Details of [ 824-80-6 ]

CAS No. :824-80-6 MDL No. :MFCD03093775
Formula : C6H4FNaO2S Boiling Point : -
Linear Structure Formula :- InChI Key :VDDUCRSPMBZLMH-UHFFFAOYSA-M
M.W : 182.15 Pubchem ID :23666220
Synonyms :

Calculated chemistry of [ 824-80-6 ]      Expand+

Physicochemical Properties

Num. heavy atoms : 11
Num. arom. heavy atoms : 6
Fraction Csp3 : 0.0
Num. rotatable bonds : 1
Num. H-bond acceptors : 3.0
Num. H-bond donors : 0.0
Molar Refractivity : 33.72
TPSA : 59.34 ?2

Pharmacokinetics

GI absorption : High
BBB permeant : Yes
P-gp substrate : Yes
CYP1A2 inhibitor : No
CYP2C19 inhibitor : No
CYP2C9 inhibitor : No
CYP2D6 inhibitor : No
CYP3A4 inhibitor : No
Log Kp (skin permeation) : -6.54 cm/s

Lipophilicity

Log Po/w (iLOGP) : -3.15
Log Po/w (XLOGP3) : 1.22
Log Po/w (WLOGP) : 2.35
Log Po/w (MLOGP) : 1.69
Log Po/w (SILICOS-IT) : 0.58
Consensus Log Po/w : 0.54

Druglikeness

Lipinski : 0.0
Ghose : None
Veber : 0.0
Egan : 0.0
Muegge : 1.0
Bioavailability Score : 0.55

Water Solubility

Log S (ESOL) : -2.08
Solubility : 1.53 mg/ml ; 0.0084 mol/l
Class : Soluble
Log S (Ali) : -2.06
Solubility : 1.57 mg/ml ; 0.00864 mol/l
Class : Soluble
Log S (SILICOS-IT) : -2.11
Solubility : 1.42 mg/ml ; 0.0078 mol/l
Class : Soluble

Medicinal Chemistry

PAINS : 0.0 alert
Brenk : 1.0 alert
Leadlikeness : 1.0
Synthetic accessibility : 2.52

Safety of [ 824-80-6 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 824-80-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 824-80-6 ]

[ 824-80-6 ] Synthesis Path-Downstream   1~4

  • 1
  • [ 824-80-6 ]
  • [ 131184-73-1 ]
  • [ 1194551-63-7 ]
  • 2
  • [ 14135-38-7 ]
  • [ 824-80-6 ]
  • [ 1394124-51-6 ]
  • 3
  • [ 824-80-6 ]
  • [ 2905-56-8 ]
  • C18H18FNO2S [ No CAS ]
  • 4
  • [ 824-80-6 ]
  • [ 68-12-2 ]
  • [ 383-31-3 ]
YieldReaction ConditionsOperation in experiment
42% General procedure: An oven-dried Schlenk tube equipped with a magnetic stir bar was charged with formamide 1 (2.0 mmol), KO-t-Bu (2.0 mmol) and CH3CN (2.0 mL). The mixture was stirred at 50 C for 30 min and then a CH3CN (2.0 mL) solution containing sodium sulfinates 2 (0.5 mmol) and NIS (1.0 mmol) was slowly added dropwise. The resulting solution stirred at 50 C for 12 h under air. The mixture was then cooled to room temperature, diluted with 30 mL of H2O, and extracted with EtOAc (3×20 mL). The combined organic extracts were dried over Na2SO4, filtered, and concentrated under vacuum. The residue was purified by column chromatography on silica gel to give the products.
Recommend Products
Same Skeleton Products

Technical Information

Historical Records

Related Functional Groups of
[ 824-80-6 ]

Fluorinated Building Blocks

Chemical Structure| 371-42-6

[ 371-42-6 ]

4-Fluorothiophenol

Similarity: 0.63

Chemical Structure| 383-50-6

[ 383-50-6 ]

2-Fluoroethyl 4-methylbenzenesulfonate

Similarity: 0.63

Chemical Structure| 143062-84-4

[ 143062-84-4 ]

(1R,2S)-2-Fluorocyclopropanamine 4-methylbenzenesulfonate

Similarity: 0.62

Chemical Structure| 114435-86-8

[ 114435-86-8 ]

Fluoromethyl 4-methylbenzenesulfonate

Similarity: 0.62

Chemical Structure| 657-46-5

[ 657-46-5 ]

1-Fluoro-3-(methylsulfonyl)benzene

Similarity: 0.60

Aryls

Chemical Structure| 873-55-2

[ 873-55-2 ]

Sodium benzenesulfinate

Similarity: 0.85

Chemical Structure| 25932-11-0

[ 25932-11-0 ]

Sodium benzenesulfinate dihydrate

Similarity: 0.85

Chemical Structure| 824-79-3

[ 824-79-3 ]

Sodium 4-methylbenzenesulfinate

Similarity: 0.78

Chemical Structure| 657-84-1

[ 657-84-1 ]

Sodium p-toluenesulfonate

Similarity: 0.73

Chemical Structure| 670-98-4

[ 670-98-4 ]

Methyl benzenesulfinate

Similarity: 0.72

; ;