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[ CAS No. 7749-47-5 ] {[proInfo.proName]}

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Chemical Structure| 7749-47-5
Chemical Structure| 7749-47-5
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Product Details of [ 7749-47-5 ]

CAS No. :7749-47-5 MDL No. :MFCD00059768
Formula : C6H9N3O Boiling Point : No data available
Linear Structure Formula :C4HN2NH2(CH3O)CH3 InChI Key :SNWZXTZIZWBIDQ-UHFFFAOYSA-N
M.W : 139.15 Pubchem ID :587236
Synonyms :

Safety of [ 7749-47-5 ]

Signal Word:Warning Class:
Precautionary Statements:P261-P305+P351+P338 UN#:
Hazard Statements:H315-H319-H335 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 7749-47-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 7749-47-5 ]

[ 7749-47-5 ] Synthesis Path-Downstream   1~13

  • 1
  • [ 5600-21-5 ]
  • [ 124-41-4 ]
  • [ 7749-47-5 ]
  • 2
  • [ 7749-47-5 ]
  • [ 121-60-8 ]
  • [ 36082-36-7 ]
YieldReaction ConditionsOperation in experiment
20% With pyridine; at 0 - 60℃; for 17.0h; Step 1: Synthesis of N-{4-[(4-methoxy-6-methylpyrimidin-2-yl)sulfamoyl] phenyl}acetamide 19.1 [00351] 4-(Acetylamino)benzenesulfonyl chloride (2.00 g, 8.56 mmol) was added at 0C to a stirred solution of <strong>[7749-47-5]4-methoxy-6-methylpyrimidin-2-amine</strong> (1.19 g, 8.56 mmol) in pyridine (dry, 20ml). The reaction mixture was allowed to reach rt and stirred for 15h then heated to 60C for 2h. The solvent was removed in vacuo by azeotroping with toluene (2 x 25ml), followed by n- heptane (2 x 25ml) to afford a brown oil which was purified by flash column chromatography (MeOH/DCM 0/100 to 5/95) to obtain 0.60g (20%) of N-{4-[(4-methoxy-6-methylpyrimidin-2- yl)sulfamoyl]phenyl}acetamide 19.1 a colourless solid.
With pyridine; at 60℃; for 12.0h; Step 1 - N-[4-[(4-methoxy-6-methyl-pyrimidin-2-yl)sulfamoyl]phenyl]acetamide (0431) [00295] To a suspension of 4-methoxy-6-methyl-pyrimidin-2-amine (4.00 g, 28.8 mmol) in pyridine (40 mL) was added 4-acetamidobenzenesulfonyl chloride (7.05 g, 30.2 mmol, CAS121-60-8). The reaction mixture was stirred at 60 C for 12 hr. On completion, the reaction mixture was concentrated and the residue was diluted with water, the solid was filtered, washed with dichloromethane (30 mL), and dried under vacuum to give the title compound. LCMS: (ES- ) m/z (M-H)- = 335.1, tR = 1.011.
  • 3
  • [ 7749-47-5 ]
  • [ 22536-64-7 ]
YieldReaction ConditionsOperation in experiment
8% With hydrogenchloride; sodium nitrite; In water; at 0 - 20℃; for 1.5h; To a solution 2-amino-4-methoxy-6-methylpyrimidine (5 g, 35.97 mmol) in aqueous concentrated HCl (50 ml) was added NaNO2 (2.97 g, 43.16 mmol) in water(5 ml) slowly drop by drop over a period 30 min at 0oC and then the reaction mixture was stirred at room temperature for 1 hour. Then, the reaction mixture was quenched with 10 N sodium hydroxide solution then insoluble material was, filtered and filtrate was partitioned between brine and AcOEt and the aqueous layer was extracted with AcOEt. The combined organic layers were dried over Na2SO4, filtered and concentrated under reduced pressure to give a brown oil. The crude compound which upon purification by flash chromatography using (silica-gel: 100-200 mesh, AcOEt -petroleum ether; 10:90→ 15:85) gave 600 mg (yield 8%) of a white solid corresponding to 2-chloro-4-methoxy-6- methylpyrimidine.
With sodium nitrite; In hydrogenchloride; water; EXAMPLE 6 2-Chloro-4-methyl-6-methoxypyrimidine A solution of 25.4 g of 2-amino-4-methyl-6-methoxypyrimidine in 150 ml concentrated hydrochloric acid was cooled to ca. 0 C. and treated with a solution of 25.3 g of sodium nitrite in 50 ml water, added over a period of 30-40 minutes. The thick orange reaction mixture was stirred at room temperature for 4-5 hours and then adjusted to pH 10 by addition of 12.5N sodium hydroxide solution. The precipitate was filtered and extracted thoroughly with approximately 600 ml of hot ether. The organic layer was dried over magnesium sulfate and concentrated in vacuo to give 7.2 g of 2-chloro-4-methyl-6-methoxypyrimidine as a white, crystalline solid, m.p. 36-38 C. NMR(CDCl3): δ 6.5 (1H, s, heterocyclic H); 4.0 (3H, s, --OCH3); 2.4 (3H, s, --CH3).
  • 4
  • [ 7749-47-5 ]
  • 3-Isocyanatosulfonyl-1-methyl-1H-indole-2-carboxylic acid methyl ester [ No CAS ]
  • 3-[[(4-methoxy-6-methylpyrimidin-2-yl)aminocarbonyl]aminosulfonyl]-1-methyl-1H-indole-2-carboxylic acid, methyl ester [ No CAS ]
  • 5
  • [ 7749-47-5 ]
  • [ 98-60-2 ]
  • [ 353302-84-8 ]
  • 6
  • [ 7749-47-5 ]
  • [ 98-59-9 ]
  • [ 330946-56-0 ]
  • 7
  • [ 7749-47-5 ]
  • [ 98-11-3 ]
  • [ 312597-84-5 ]
  • 8
  • [ 7749-47-5 ]
  • [ 2905-23-9 ]
  • [ 130240-03-8 ]
  • 9
  • [ 7749-47-5 ]
  • [ 140160-21-0 ]
  • 1-(4-methoxy-6-methyl-pyrimidin-2-yl)-3-[5-(4-nitro-phenyl)-furan-2-carbonyl]-thiourea [ No CAS ]
  • 10
  • [ 7749-47-5 ]
  • [ 304437-60-3 ]
  • 1-[5-(2-chloro-phenyl)-furan-2-carbonyl]-3-(4-methoxy-6-methyl-pyrimidin-2-yl)-thiourea [ No CAS ]
  • 11
  • [ 936020-75-6 ]
  • [ 7749-47-5 ]
  • C12H15N5O2S2 [ No CAS ]
  • 12
  • [ 7749-47-5 ]
  • 5-Methoxy-2,7-dimethyl-imidazo[1,2-a]pyrimidine-3-carboxylic acid [ No CAS ]
  • 13
  • [ 7749-47-5 ]
  • 5-methoxy-7-methylimidazo<1,2-a>pyrimidine-2-carboxylic acid [ No CAS ]
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