[ CAS No. 7521-41-7 ] {[proInfo.proName]}

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2D 3D

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Quality Control of [ 7521-41-7 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 7521-41-7 ]

SDS Specification

Alternatived Products of [ 7521-41-7 ]

Product Details of [ 7521-41-7 ]

CAS No. :	7521-41-7	MDL No. :	MFCD01830382
Formula :	C₆H₆N₂O	Boiling Point :	No data available
Linear Structure Formula :	-	InChI Key :	NXMFJCRMSDRXLD-UHFFFAOYSA-N
M.W :	122.13	Pubchem ID :	737633
Synonyms :

Calculated chemistry of [ 7521-41-7 ] Expand+

Physicochemical Properties

Num. heavy atoms :	9
Num. arom. heavy atoms :	6
Fraction Csp3 :	0.0
Num. rotatable bonds :	1
Num. H-bond acceptors :	2.0
Num. H-bond donors :	1.0
Molar Refractivity :	34.03
TPSA :	55.98 ?2

Pharmacokinetics

GI absorption :	High
BBB permeant :	No
P-gp substrate :	No
CYP1A2 inhibitor :	No
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-6.68 cm/s

Lipophilicity

Log Po/w (iLOGP) :	0.75
Log Po/w (XLOGP3) :	0.52
Log Po/w (WLOGP) :	0.48
Log Po/w (MLOGP) :	-0.43
Log Po/w (SILICOS-IT) :	0.8
Consensus Log Po/w :	0.43

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	1.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	-1.35
Solubility :	5.43 mg/ml ; 0.0445 mol/l
Class :	Very soluble
Log S (Ali) :	-1.27
Solubility :	6.61 mg/ml ; 0.0542 mol/l
Class :	Very soluble
Log S (SILICOS-IT) :	-1.57
Solubility :	3.3 mg/ml ; 0.027 mol/l
Class :	Soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	1.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	1.13

Safety of [ 7521-41-7 ]

Signal Word:	Warning	Class:
Precautionary Statements:	P261-P305+P351+P338	UN#:
Hazard Statements:	H315-H319-H335	Packing Group:
GHS Pictogram:

Application In Synthesis of [ 7521-41-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 7521-41-7 ]
Downstream synthetic route of [ 7521-41-7 ]

[ 7521-41-7 ] Synthesis Path-Upstream 1~1

1
[ 7521-41-7 ]
[ 445490-61-9 ]

Reference： [1] Bioorganic and Medicinal Chemistry Letters, 2005, vol. 15, # 10, p. 2679 - 2684

[ 7521-41-7 ] Synthesis Path-Downstream 1~10

1
[ 7521-41-7 ]
[ 67-64-1 ]
[ 1569-16-0 ]

Yield	Reaction Conditions	Operation in experiment
99%	With L-proline; In ethanol; for 16h;Reflux;	[00227] A solution of 2-aminonicotinaldehyde (1 1.10 g, 91 mmol), acetone (15.83 g, 272.9 mmol), and L-proline (1 1.40 g, 100.1 mmol) in ethanol (120 mL) was stirred at reflux for 16 h. The reaction solution was then cooled to room temperature, concentrated and the residue was dissolved in dichloromethane (100 mL) and filtrated. The filtrate was washed with water (3 x 100 mL) and the organic phase was dried with anhydrous sodium sulfate, filtered, concentrated under reduced pressure, and the residue was purified by flash chromatography eluting with ethyl acetate:petrol ether (1 : 10) to give the title compound as a white solid (13.0 g, 99%). MS (ESI): m/z 145 [M + H]+.
99%	With L-proline; In ethanol; for 15h;Reflux; Inert atmosphere;	A mixture of 2-aminopyridine-3-carboxyaldehyde (5.125 g, 42.0 mmol), acetone (9.5 mL, 126.0 mmol) and L-proline (5.31 g, 46.2 mmol) in absolute ethyl alcohol (70 mL) was heated at reflux overnight (15 h) under nitrogen atmosphere. The solvent was evaporated in vacuo to afford a canary yellow solid. The solid was dissolved in dichloromethane (50 mL) to give a white precipitate, filtered, washed with dichloromethane and the combined filtrate was evaporated in vacuo to give a yellow- orange residue. The solid was redissolved in dichloromethane (50 mL), washed with water (1×50 mL), the organic layer was separated and the aqueous layer was extracted with dichloromethane (1×25 mL). The combined organic extract was washed with brine (1×50 mL), dried over anhydrous Na2SO4, filtered and evaporated in vacuo to afford a dirty yellow solid (6.04 g, yield 99%). GC-MS analysis of the solid shows the desired product?s mass: m/z 144 (M+); Calculated for C9H8N2:144.17. 1H NMR (400 MHz, CDCl3): delta 2.83 (s, 3H), 7.38 (d, J = 8.00 Hz, 1H), 7.45 (dd, 1H), 8.09 (d, J = 8.00 Hz, 1H), 8.16 (d, J = 8.00 Hz, 1H), 9.08 (s, 1H). 1H NMR spectrum of the sample was consistent with the suggested structure of the product.
97%	With L-proline;Heating / reflux;	Step 1. Synthesis of 2-METHYL-1, 8-naphthyridine.To 2-amino-3-nicotinaldehyde (50.0 g, 0.41 mol) in EtOH (600 mL) was added L-proline (51 g, 0.45 mol) and acetone (90 mL, 1.23 MOL). The reaction mixture was REFLUXED overnight. The reaction mixture was cooled to room temperature and the white solid filtered. The filtrate was concentrated to a yellowish SOLID, REDISSOLVED in CH2CI2 (500 mL), and the insolubles filtered. The filtrate was washed with water (2 x 100 mL), the organic layer was separated and the aqueous layers combined and washed with CH2CI2 (4 x 75 mL). The organic layers were combined, washed with brine, dried over NA2SO4 and concentrated to a yellow solid (57.2 g, 0.40 mol, 97%).

95%	With L-proline; In ethanol; acetone; at 78 - 80℃; for 12h;	Step one: 2-amino-3-pyridinecarboxaldehyde (28mmol, 3.4g, purchased from Nanjing New Anjie Chemical Technology Co., Ltd. No. NE229) l-proline (28mmol, 3.2g, purchased from Beijing Coupling Technology Co., Ltd. 141218 The brand name) was dissolved in ethanol (100 mL), acetone (834 mmol, 48 g) was added, and the mixture was heated to reflux (78-80 C.) for 12 h. The solvent was distilled off under reduced pressure to obtain a crude solid product, which was then subjected to column chromatography (eluent). The volume ratio of 3/1 petroleum ether/ethyl acetate mixture was further purified to give 2-methyl-1,8-naphthyridine in a yield of 95%.
90%	With potassium hydroxide; In methanol; acetone;Reflux;	Under a N2 atmosphere, a 100-mL flask was charged with 2-amino-3-pyridinecarboxaldehyde (2 g, 16.4 mmol) and dry acetone (20 mL). After the solution was refluxed for 5 min, a freshly prepared saturated solution of KOH in MeOH (0.1 mL) was added dropwise and the mixture was refluxed for 24 h. After cooling to room temperature, the solvent was removed under vacuum. The product was further purified by flash chromatography on a silica gel column to afford a brown yellow solid. m.p. 98-100 C. Yield: 90% (2.1 g, 14.8 mmol). 1H-NMR (400 MHz, CDCl3) delta (ppm): 9.08 (dd, J = 4.0 Hz, J = 1.6 Hz, 1H), 8.16 (dd, J = 8.0 Hz, J = 2.0 Hz, 1H), 8.09 (d, J = 8.0 Hz, 1H), 7.45 (dd, J = 8.0 Hz, J = 4.4 Hz, 1H), 7.39 (d, J = 8.0 Hz, 1H), 2.83 (s, 1H); 13C-NMR (100 MHz, CDCl3) delta: 162.9, 155.8, 153.2, 136.7, 122.9, 121.2, 120.6, 25.5 ppm. Anal. Calcd for C9H8N2: C 74.98; H 5.59, N 19.43. Found: C 74.88; H 5.47, N 19.65.
88.3%	With methanol; potassium hydroxide; at 55℃; for 6h;	To a stirred solution of 2-amino-3-formyl pyridine (7 g, 57 mmol) in acetone (70 mL), a saturated solution of KOH in methanol (0.5 mL) was added and the mixture was stirred at 55 C for 6 h. Completion of the reaction was monitored by TLC. The mixture was concentrated and the resulting crude product was purified by flash chromatography (Elutant: 65-85 % EtOAc in pet ether) to give the title compound. Yield: 88.3% (7.3 g, palebrown solid). 1H NMR (400 MHz, CDCI3): 69.10-9.09 (m, IH), 8.18-8.15 (m, IH), 8.09 (d, J = 8.4 Hz, IH), 7.47-7.39 (m, IH), 7.29-7.28 (m, IH), 2.84 (s, 3H). LCMS: (Method B) 145.0 (M +H), Rt. 3.06 mm, 97.85% (Max). HPLC: (Method B) Rt 2.98 mm, 98.09% (Max).
88.3%	With potassium hydroxide; In methanol; acetone; at 55℃; for 6h;	To a stirred solution of 2-amino-3-formyl pyridine (7 g, 57 mmol) in acetone (70 mL), a saturated solution of KOH in methanol (0.5 mL) was added and the mixture was stirred at 55 C for 6 h. Completion of the reaction was monitored by TLC. The mixture was concentrated and the resulting crude product was purified by flash chromatography (Elutant: 65-85 % EtOAc in pet ether) to give the title compound. Yield: 88.3% (7.3 g, pale brown solid). 1H NMR (400 MHz, CDCI3): delta 9.10-9.09 (m, 1 H), 8.18-8.15 (m, 1 H), 8.09 (d, J = 8.4 Hz, 1 H), 7.47-7.39 (m, 1 H), 7.29-7.28 (m, 1 H), 2.84 (s, 3H). LCMS: (Method B) 145.0 (M +H), Rt. 3.06 min, 97.85% (Max). HPLC: (Method B) Rt 2.98 min, 98.09% (Max).
69%	With piperidine; In ethanol; for 24h;Heating / reflux;	The compound was prepared according to the procedure as described by E. M. Hawes and D. G. Wibberley, J. Chem. Soc. (C), 1966, 315. To a solution of 2-amino-3-pyridinecarboxaldehyde (2 g, 16 mmol) in ethanol 3 ml) was added acetone (1.9 g, 32 mmol) and peperidine (0,34 g, 4 mmol) and the reaction mixture was refluxed 24 hours. Reaction mixture was cooled to room temperature then concentrated in vacuum. Ether was added to concentrated residue. Solid was filtered and dried to give 1.62 g (69%) yellow solid. NMR (CD3OD) delta 2.76 (s, 3H), 7.52-7.58 (m, 2H), 8.30 (d, 2H, J=8.33 Hz), 8.36-8.39 (m, 1H), 8.39-8.99 (m, 1H).
69%	With piperidine; In ethanol; for 24h;Heating / reflux;	To a solution of 2-amino-3-pyridinecarboxaldehyde (2 g, 16 mmol) in ethanol3 mL) was added acetone (1.9 g, 32 mmol) and piperidine (0.34 g, 4 mmol and the reaction10 mixture was refluxed 24 hours. Reaction mixture was cooled to room temperature thenconcentrated in vacuum. Ether was added to concentrated residue. Solid was filtered anddried to give 1.62 g (69%) yellow solid. NMR (CD3OD) 6 8.39-8.99 (m, 1H), 8.36-8.39 (m,1H), 8.30 (d, 2H, J = 8.33 Hz), 7.52-7.58 (m, 2H), 2.76 (s, 3H). M + H - 145.
	With L-proline; In ethanol; for 8h;Reflux;	(e) 2-Methyl-l ,8-naphthyridine[00448] To a suspension of 2-aminonicotinaldehyde (732 mg, 6 mmol) and L-proline (69 mg, 0.6 mmol) in EtOH (15 mL) was added acetone (1.74 g, 30 mmol). Then the mixture was heated at reflux and stirred for 8 h. The resulting mixture was concentrated under reduced pressure to give a residue, which was washed with water (10 mL) and extracted with DCM (15 mL x 3). The combined organic layers were washed with brine (10 mL), dried over anhydrous sodium sulfate, and concentrated under reduced pressure to afford the crude product 2-methyl-l,8-naphthyridine as a yellow solid (768 mg). MS (ESI): m/z 145 [M+H]+. See e.g. , Bioorg. Med. Chem. Lett., 2005, 15, 2679-84.
	With L-proline; In ethanol;	Int-19A was prepared using the procedure described in Patent: WO 2011150156. NMR (500MHz, DMSO-c) delta 9.02 (dd, J = 4.3, 2.1 Hz, 1H), 8.40 (dd, J = 8.0, 1.9 Hz, 1H), 8.34 (d, J = 8.3 Hz, 1H), 7.56 (dd, J = 8.1, 4.3 Hz, 1H), 7.51 (s, 1H), 2.70 (s, 3H). HPLC retention time (Method 1): 0.303 mia; LCMS (ES): m/z 145.0 [M+H]+.

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2005,vol. 15,p. 2679 - 2684
[2]Patent: WO2014/85284,2014,A1 .Location in patent: Paragraph 00227
[3]Organic and Biomolecular Chemistry,2016,vol. 14,p. 6683 - 6686
[4]Patent: WO2018/132268,2018,A1 .Location in patent: Page/Page column 57
[5]Green Chemistry,2019,vol. 21,p. 3050 - 3058
[6]Patent: WO2004/58761,2004,A1 .Location in patent: Page 32
[7]Organic Letters,2016,vol. 18,p. 2730 - 2733
[8]Patent: CN105111208,2018,B .Location in patent: Paragraph 0206; 0208
[9]Journal of the American Chemical Society,2015,vol. 137,p. 6168 - 6171
[10]Tetrahedron Letters,2017,vol. 58,p. 726 - 731
[11]Patent: WO2017/144633,2017,A1 .Location in patent: Page/Page column 118; 119
[12]Patent: WO2017/144639,2017,A1 .Location in patent: Page/Page column 102-103
[13]Patent: US2004/92538,2004,A1 .Location in patent: Page 33
[14]Patent: WO2005/51904,2005,A2 .Location in patent: Page/Page column 29
[15]Bioorganic and Medicinal Chemistry Letters,2006,vol. 16,p. 3156 - 3161
[16]Organic Letters,2010,vol. 12,p. 5359 - 5361
[17]Patent: WO2011/150156,2011,A2 .Location in patent: Page/Page column 127
[18]Patent: US2014/221410,2014,A1 .Location in patent: Paragraph 0360
[19]Organic and Biomolecular Chemistry,2017,vol. 15,p. 6093 - 6097
[20]Chemistry Letters,2018,vol. 47,p. 400 - 403
[21]Patent: WO2018/89360,2018,A1 .Location in patent: Page/Page column 67
[22]Journal of the American Chemical Society,2018,vol. 140,p. 8662 - 8666
[23]Patent: WO2019/94319,2019,A1 .Location in patent: Page/Page column 39

2
[ 7521-41-7 ]
[ 815-68-9 ]
[ 254-60-4 ]
[ 1569-16-0 ]

Reference： [1]Heterocycles,2005,vol. 65,p. 2777 - 2782

3
[ 7521-41-7 ]
[ 1569-16-0 ]

Yield	Reaction Conditions	Operation in experiment
1.62 g (69%)	In ethanol; acetone;	Step 4 2-methyl-1,8-naphthyridine The compound was prepared according to the procedure as described by E. M. Hawes and D. G. Wibberley, J. Chem. Soc. (C), 1966, 315. To a solution of 2-amino-3-pyridinecarboxaldehyde (2 g, 16 mmol) in ethanol 3 ml) was added acetone (1.9 g, 32 mmol) and peperidine (0,34 g, 4 mmol) and the reaction mixture was refluxed 24 hours. Reaction mixture was cooled to room temperature then concentrated in vacuum. Ether was added to concentrated residue. Solid was filtered and dried to give 1.62 g (69percent) yellow solid. NMR (CD3OD) delta 2.76 (s, 3H), 7.52-7.58 (m, 2H), 8.30 (d, 2H, J=8.33 Hz), 8.36-8.39 (m, 1H), 8.39-8.99 (m, 1H).
1.62 g (69%)	In ethanol; acetone;	Step 4 2-methyl-1,8-naphthyridine The compound was prepared according to the procedure as described by E. M. Hawes and D. G. Wibberley, J. Chem. Soc. (C), 1966, 315. To a solution of 2-amino-3-pyridinecarboxaldehyde (2 g, 16 mmol) in ethanol 3 ml) was added acetone (1.9 g, 32 mmol) and peperidine (0,34 g, 4 mmol) and the reaction mixture was refluxed 24 hours. Reaction mixture was cooled to room temperature then concentrated in vacuum. Ether was added to concentrated residue. Solid was filtered and dried to give 1.62 g (69percent) yellow solid. NMR (CD3OD) delta 2.76 (s, 3H), 7.52-7.58 (m, 2H), 8.30 (d, 2H, J=8.33 Hz), 8.36-8.39 (m, 1H), 8.39-8.99 (m, 1H).
	With rac-Pro-OH; In acetone; for 48h;Heating / reflux;	To a solution of 2-amino-3-pyridinecarboxaldehyde (from step c, 24.57 g) in acetone (750 mL) was added proline (2.3 g, 20 mmole), then the mixture was heated to reflux. After 48 hr the mixture was cooled to RT, filtered, and concentrated. Flash column chromatography on silica gel (35percent acetone/hexanes) gave the title compound (18.5 g, 64percent over 3 steps) as an orangish-yellow solid: 1H NMR (300 MHz, CDCl3) delta 9.07 (m, 1H), 8.10 (m, 2 H), 7.40 (m, 2 H), 2.80 (s, 3 H); MS (ES) m/e 145 (M + H)+.

Reference： [1]Patent: US2002/77321,2002,A1
[2]Patent: US6921767,2005,B2
[3]Patent: EP1218005,2004,B1 .Location in patent: Page 22

4
[ 110-89-4 ]
[ 7521-41-7 ]
[ 1569-16-0 ]

Yield	Reaction Conditions	Operation in experiment
1.62 g (69%)	In ethanol; acetone;	Step 4 2-methyl-1,8-naphthyridine. (E. M. Hawes, D. G. Wibberly. J. Chem. Soc(C). 1966, 315) To a solution of 2-amino-3-pyridinecarboxaldehyde (2 g, 16 mmol) in ethanol (3 mL) was added acetone (1.9 g, 32 mmol) and piperidine (0.34 g, 4 mmol) and the reaction mixture was refluxed 24 hours. Reaction mixture was cooled to room temperature then concentrated in vacuum. Ether was added to concentrated residue. The solid was filtered and dried to give 1.62 g (69percent) yellow solid. 1H NMR (CD3OD) delta8.39-8.99 (m, 1H) 8.36-8.39 (m, 1H), 8.30 (d, 2H, J=8.33 Hz), 7.52-7.58 (m, 2H), 2.76 (s, 3H).

Reference： [1]Patent: US2002/72518,2002,A1

5
[ 7521-41-7 ]
[ 326-62-5 ]
[ 1082583-45-6 ]

Reference： [1]Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry,2010,vol. 49,p. 500 - 504

6
[ 7521-41-7 ]
[ 38430-55-6 ]
[ 1314795-63-5 ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2011,vol. 21,p. 3596 - 3602

7
[ 7521-41-7 ]
[ 332883-10-0 ]

Reference： [1]Patent: US2011/319400,2011,A1

8
[ 7521-41-7 ]
[ 5654-97-7 ]

Reference： [1]Tetrahedron Letters,2015,vol. 56,p. 6370 - 6372

9
[ 7521-41-7 ]
[ 123-42-2 ]
[ 1569-16-0 ]

Reference： [1]Organic and Biomolecular Chemistry,2016,vol. 14,p. 8966 - 8970
[2]Organic and Biomolecular Chemistry,2016,vol. 14,p. 7282 - 7294

10
[ 7521-41-7 ]
[ 15121-66-1 ]
[ 1569-16-0 ]

Reference： [1]Organic and Biomolecular Chemistry,2016,vol. 14,p. 8966 - 8970

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? Barbier Coupling Reaction ? Baylis-Hillman Reaction ? Bucherer-Bergs Reaction ? Buchwald-Hartwig C-N Bond and C-O Bond Formation Reactions ? Chan-Lam Coupling Reaction ? Clemmensen Reduction ? Complex Metal Hydride Reductions ? Corey-Chaykovsky Reaction ? Corey-Fuchs Reaction ? Fischer Indole Synthesis ? Grignard Reaction ? Hantzsch Dihydropyridine Synthesis ? Henry Nitroaldol Reaction ? Horner-Wadsworth-Emmons Reaction ? Hydride Reductions ? Julia-Kocienski Olefination ? Knoevenagel Condensation ? Leuckart-Wallach Reaction ? Mannich Reaction ? McMurry Coupling ? Meerwein-Ponndorf-Verley Reduction ? Mukaiyama Aldol Reaction ? Nozaki-Hiyama-Kishi Reaction ? Passerini Reaction ? Paternò-Büchi Reaction ? Petasis Reaction ? Pictet-Spengler Tetrahydroisoquinoline Synthesis ? Preparation of Aldehydes and Ketones ? Preparation of Amines ? Prins Reaction ? Reactions of Aldehydes and Ketones ? Reactions of Amines ? Reformatsky Reaction ? Schlosser Modification of the Wittig Reaction ? Schmidt Reaction ? Specialized Acylation Reagents-Vilsmeier Reagent ? Stetter Reaction ? Stobbe Condensation ? Tebbe Olefination ? Ugi Reaction ? Wittig Reaction ? Wolff-Kishner Reduction

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P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

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[ CAS No. 7521-41-7 ] {[proInfo.proName]}

Quality Control of [ 7521-41-7 ]

Related Doc. of [ 7521-41-7 ]

Product Details of [ 7521-41-7 ]

Calculated chemistry of [ 7521-41-7 ] Expand+

Physicochemical Properties

Pharmacokinetics

Lipophilicity

Druglikeness

Water Solubility

Medicinal Chemistry

Safety of [ 7521-41-7 ]

Application In Synthesis of [ 7521-41-7 ]

[ 7521-41-7 ] Synthesis Path-Upstream 1~1

[ 7521-41-7 ] Synthesis Path-Downstream 1~10

Technical Information

Related Functional Groups of [ 7521-41-7 ]

Aldehydes

Amines

Related Parent Nucleus of [ 7521-41-7 ]

Pyridines

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Related Functional Groups of
[ 7521-41-7 ]

Related Parent Nucleus of
[ 7521-41-7 ]