[ CAS No. 6645-46-1 ] {[proInfo.proName]}

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Quality Control of [ 6645-46-1 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 6645-46-1 ]

SDS Specification

Alternatived Products of [ 6645-46-1 ]

Product Details of [ 6645-46-1 ]

CAS No. :	6645-46-1	MDL No. :	MFCD00066100
Formula :	C₇H₁₆ClNO₃	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	JXXCENBLGFBQJM-FYZOBXCZSA-N
M.W :	197.66	Pubchem ID :	656657
Synonyms :	(R)-Carnitine hydrochloride;Levocarnitine hydrochloride;LC-80;L-Carnitine chloride;Levocarnitine chloride	Chemical Name :	(R)-3-Carboxy-2-hydroxy-N,N,N-trimethylpropan-1-aminium chloride

Safety of [ 6645-46-1 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P305+P351+P338	UN#:	N/A
Hazard Statements:	H315-H319-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 6645-46-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 6645-46-1 ]
Downstream synthetic route of [ 6645-46-1 ]

[ 6645-46-1 ] Synthesis Path-Upstream 1~8

1
[ 541-15-1 ]
[ 6645-46-1 ]

Reference： [1] Patent: WO2017/195031, 2017, A1, . Location in patent: Page/Page column 12; 13

2
[ 10488-69-4 ]
[ 75-50-3 ]
[ 6645-46-1 ]

Reference： [1] Patent: WO2007/139238, 2007, A1, . Location in patent: Page/Page column 9-10

3
[ 2788-28-5 ]
[ 6645-46-1 ]

Reference： [1] Chinese Chemical Letters, 2011, vol. 22, # 7, p. 765 - 767
[2] Canadian Journal of Chemistry, 1969, vol. 47, p. 1177 - 1187

4
[ 107799-28-0 ]
[ 6645-46-1 ]

Reference： [1] Journal of Organic Chemistry, 1987, vol. 52, # 11, p. 2311 - 2314

5
[ 86728-99-6 ]
[ 75-50-3 ]
[ 6645-46-1 ]

Reference： [1] Journal of the American Chemical Society, 1983, vol. 105, # 18, p. 5925 - 5926

6
[ 111006-14-5 ]
[ 75-50-3 ]
[ 6645-46-1 ]

Reference： [1] Journal of Organic Chemistry, 1988, vol. 53, # 1, p. 104 - 107

7
[ 10488-69-4 ]
[ 124-40-3 ]
[ 6645-46-1 ]

Reference： [1] Tetrahedron, 1985, vol. 41, # 23, p. 5607 - 5614

8
[ 18933-33-0 ]
[ 6645-46-1 ]

Reference： [1] Canadian Journal of Chemistry, 1969, vol. 47, p. 1177 - 1187

[ 6645-46-1 ] Synthesis Path-Downstream 1~11

1
[ 2788-28-5 ]
[ 6645-46-1 ]

Reference： [1]Chinese Chemical Letters,2011,vol. 22,p. 765 - 767
[2]Canadian Journal of Chemistry,1969,vol. 47,p. 1177 - 1187

2
[ 6645-46-1 ]
[ 541-88-8 ]
(R)-(-)-Chloracetylcarnitin [ No CAS ]

Reference： [1]Journal of medicinal chemistry,1971,vol. 14,p. 1142 - 1142

3
[ 6645-46-1 ]
[ 107-07-3 ]
(-)-Carnitin-(2-chlor-aethylester)-chlorid [ No CAS ]

Reference： [1]Canadian Journal of Chemistry,1969,vol. 47,p. 1177 - 1187

4
[ 10488-69-4 ]
[ 75-50-3 ]
[ 6645-46-1 ]

Yield	Reaction Conditions	Operation in experiment
		Example 5: Preparation of acetyl L-carnitine hydrochloride (7s); [60] 37 mL (0.156 mole) of an aqueous 30wt/% trimethylamine solution was placed in10 g (0.06 mole) of ethyl (R)-4-chloro-3-hydroxybutyrate, and the mixture was heated and stirred at a temperature of 80 to 90 0C for 3 hours. The conversion (%) of the substrate was confirmed by gas chromatography. After the reaction was complete, excessive trimethylamine was removed by distillation under reduced pressure. 70 mL of 10 % HCl was added to the resulting concentrated solution which was then heated and stirred at a temperature of 80 to 90 0C for 2 hours, concentrated by distillation under reduced pressure, and recrystallized from small amounts of anhydrous ethanol <n="11"/>and acetone to afford L-carnitine hydrochloride. The optical purity of the product was measured using a polarimeter. The specific rotation of L-carnitine hydrochloride is as follows: [61] [alpha]25 = -22 (C=l, H O)

Reference： [1]Patent: WO2007/139238,2007,A1 .Location in patent: Page/Page column 9-10

5
[ 6645-46-1 ]
[ 64-19-7 ]
[ 75-36-5 ]
[ 5080-50-2 ]

Yield	Reaction Conditions	Operation in experiment
	at 20℃; for 0.666667h;	The thus-obtained <strong>[6645-46-1]L-<strong>[6645-46-1]carnitine hydrochloride</strong></strong> was dissolved in 20 mL of acetic acid, and 9 mL of acetyl chloride was slowly added dropwise thereto. The mixture was stirred at room temperature for about 40 min. 100 mL of ether was added to the reaction solution which was then stirred to obtain solids. The solids were recrystallized from small amounts of ethanol and acetone to give 4.5 g of acetyl <strong>[6645-46-1]L-<strong>[6645-46-1]carnitine hydrochloride</strong></strong> having a high optical purity. The optical purity of the product was confirmed using a polarimeter. The specific rotation of acetyl <strong>[6645-46-1]L-<strong>[6645-46-1]carnitine hydrochloride</strong></strong> is as follows:[64] Specific rotation [alpha]25 = -28 (C=I, H O)

Reference： [1]Patent: WO2007/139238,2007,A1 .Location in patent: Page/Page column 10

6
[ 6645-46-1 ]
[ 3040-38-8 ]