天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

Home Cart 0 Sign in  

[ CAS No. 65753-47-1 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
HazMat Fee +

There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Chemical Structure| 65753-47-1
Chemical Structure| 65753-47-1
Structure of 65753-47-1 * Storage: {[proInfo.prStorage]}

Please Login or Create an Account to: See VIP prices and availability

Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Search after Editing

* Storage: {[proInfo.prStorage]}

* Shipping: {[proInfo.prShipping]}

Quality Control of [ 65753-47-1 ]

Related Doc. of [ 65753-47-1 ]

Alternatived Products of [ 65753-47-1 ]
Product Citations

Product Details of [ 65753-47-1 ]

CAS No. :65753-47-1 MDL No. :MFCD00042223
Formula : C6H3ClF3N Boiling Point : -
Linear Structure Formula :- InChI Key :RXATZPCCMYMPME-UHFFFAOYSA-N
M.W : 181.54 Pubchem ID :589833
Synonyms :

Safety of [ 65753-47-1 ]

Signal Word:Danger Class:6.1,8
Precautionary Statements:P260-P264-P270-P273-P280-P301+P310+P330-P301+P330+P331-P303+P361+P353-P304+P340+P310-P305+P351+P338+P310-P314-P361+P364-P405-P501 UN#:2928
Hazard Statements:H301+H311-H314-H372-H412 Packing Group:Ⅱ
GHS Pictogram:

Application In Synthesis of [ 65753-47-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 65753-47-1 ]

[ 65753-47-1 ] Synthesis Path-Downstream   1~6

  • 1
  • [ 67-56-1 ]
  • [ 65753-47-1 ]
  • [ 121643-44-5 ]
  • 2
  • [ 65753-47-1 ]
  • [ 330793-45-8 ]
  • <i>N</i>-phenyl-4-(3-trifluoromethyl-pyridin-2-yl)-benzamide [ No CAS ]
  • 3
  • [ 67-56-1 ]
  • [ 124-41-4 ]
  • [ 65753-47-1 ]
  • [ 121643-44-5 ]
YieldReaction ConditionsOperation in experiment
for 18h;Heating / reflux; EXAMPLE 2Synthesis of Additional Representative Substituted Biaryl Ouinolin-4-ylamine AnaloguesA. 5-Trifluoromethyl-6-[8-('5-trifluoromethyl-pyridm-2-ylammo)-pyrido[2,3-&lpyrazin-3-yll- nicotinamide (compound 4) 1. 2-Methoxy-3-trifluoromethyl-pyridine Heat a mixture of 2-chloro-3-trifluoromethyl-pyridine (1.8 g, 10 mmol) and sodium methoxide (4M, 5 mL, 20 mmol) in MeOH (20 mL) at reflux for 18 hours. Cool the mixture and remove the volatiles by rotary evaporation. Dissolve the residue in EtOAc (50 mL) and wash with water (50 mL), saturated NaHCO3(aq) (50 mL) and brine (50 mL). Dry the organic extract overMgSO4 and remove the solvent under reduced pressure to yield the title compound.
  • 4
  • [ 80500-28-3 ]
  • [ 65753-47-1 ]
  • [ 76-05-1 ]
  • [ 861102-62-7 ]
YieldReaction ConditionsOperation in experiment
EXAMPLE 4 (a) 2-Nitro-4-(3-trifluoromethyl-pyridin-2-yl)-benzoic acid, trifluoroacetic acid salt.; A mixture of 2-chloro-3-trifluoromethyl-pyridine (181 mg, 1 mmol, TCI America), 4-carboxy-3-nitro-phenyl boronic acid (232 mg, 1.1 mmol), Pd(PPh3)4 (81 mg, 0.07 mmol, Aldrich), CsF (380 mg, 2.5 mmol) and water (2 mL) in dioxane (1.5 mL) was heated in a microwave synthesizer at 140 C. for 15 min. The reaction mixture was diluted with water (1 mL) and 1 N NaOH (1 mL), and extracted with diethyl ether (20 mL). The aqueous layer was separated, acidified with 2 N HCl and extracted with EtOAc (2×20 mL). The combined organic extracts were washed with brine, dried over MgSO4 and filtered. The filtrate was evaporated in vacuo and the residue was purified by preparative HPLC (gradient 0.1% trifluoroacetic acid in acetonitrile) to provide the title compound as a brown amorphous solid. MS (ESI, pos. ion) m/z: 313 (M+1).
  • 5
  • [ 124-41-4 ]
  • [ 65753-47-1 ]
  • [ 121643-44-5 ]
YieldReaction ConditionsOperation in experiment
89% In methanol; at 20℃; for 48h; 2-Chloro-3-trifluoromethyl-pyridine (3 g, 16.53 mmol) was dissolved in 30ml of a solution of sodium methoxide (5.4M) in methanol. The mixture was stirred at ambient temperature for 2 days. After this period of time, the reaction was taken into ice and extracted with DCM three times. The combined extract was washed with brine, dried over magnesium sulfate and concentrated in vacuo to give 2-methoxy-3-trifluoromethyl-pyridine as a light liquid (2.7 g, 89% yield). 1 H-NMR (400 MHz, DMSO-d6, 298 K): ? ppm 3.98 (s, 3H) 7.2 (dd, 1 H) 8.1 1 (d, 1 1-1) 8.45 (d, 1 H). MS: 178.1 [M+1 ]+, Rt(1) =1 .29 min.
89% In methanol; at 20℃; for 48h; 2-Chloro-3-trifluoromethyl-pyridine (3 g, 16.53 mmol) was dissolved in 30ml of a solution of sodium methoxide (5.4M) in methanol. The mixture was stirred at ambient temperature for 2 days. After this period of time, the reaction was taken into ice and extracted with DCM three times. The combined extract was washed with brine, dried over magnesium sulfate and concentrated in vacuo to give 2-methoxy-3-trifluoromethyl-pyridine as a light liquid (2.7 g, 89% yield). 1H-NMR (400 MHz, DMSO-d6, 298 K): delta ppm 3.98 (s, 3H) 7.2 (dd, 1 H) 8.11 (d, 1 H) 8.45 (d, 1 H). MS: 178.1 [M+1 ]+, Rt(1) =1.29 min.
89% With methanol; at 20℃; for 48h; 2-Methoxy-3-trifluoromethyl-pyridine 2-Chloro-3-trifluoromethyl-pyridine (3 g, 16.53 mmol) was dissolved in 30 ml of a solution of sodium methoxide (5.4M) in methanol. The mixture was stirred at ambient temperature for 2 days. After this period of time, the reaction was taken into ice and extracted with DCM three times. The combined extract was washed with brine, dried over magnesium sulfate and concentrated in vacuo to give 2-methoxy-3-trifluoromethyl-pyridine as a light liquid (2.7 g, 89% yield). 1H-NMR (400 MHz, DMSO-d6, 298 K): delta ppm 3.98 (s, 3H) 7.2 (dd, 1H) 8.11 (d, 1H) 8.45 (d, 1H). MS: 178.1 [M+1]+, Rt(1)=1.29 min.
  • 6
  • [ 65753-47-1 ]
  • [ 99368-67-9 ]
Recommend Products
Same Skeleton Products

Technical Information

Historical Records

Related Functional Groups of
[ 65753-47-1 ]

Fluorinated Building Blocks

Chemical Structure| 70158-59-7

[ 70158-59-7 ]

2,5-Dichloro-3-(trifluoromethyl)pyridine

Similarity: 0.93

Chemical Structure| 211122-40-6

[ 211122-40-6 ]

5-Bromo-2-chloro-3-(trifluoromethyl)pyridine

Similarity: 0.84

Chemical Structure| 55304-75-1

[ 55304-75-1 ]

2,6-Dichloro-3-(trifluoromethyl)pyridine

Similarity: 0.84

Chemical Structure| 1211578-93-6

[ 1211578-93-6 ]

6-Chloro-5-(trifluoromethyl)pyridin-3-ol

Similarity: 0.83

Chemical Structure| 887707-25-7

[ 887707-25-7 ]

2-Chloro-5-iodo-3-(trifluoromethyl)pyridine

Similarity: 0.83

Chlorides

Chemical Structure| 70158-59-7

[ 70158-59-7 ]

2,5-Dichloro-3-(trifluoromethyl)pyridine

Similarity: 0.93

Chemical Structure| 211122-40-6

[ 211122-40-6 ]

5-Bromo-2-chloro-3-(trifluoromethyl)pyridine

Similarity: 0.84

Chemical Structure| 55304-75-1

[ 55304-75-1 ]

2,6-Dichloro-3-(trifluoromethyl)pyridine

Similarity: 0.84

Chemical Structure| 1211578-93-6

[ 1211578-93-6 ]

6-Chloro-5-(trifluoromethyl)pyridin-3-ol

Similarity: 0.83

Chemical Structure| 887707-25-7

[ 887707-25-7 ]

2-Chloro-5-iodo-3-(trifluoromethyl)pyridine

Similarity: 0.83

Trifluoromethyls

Chemical Structure| 70158-59-7

[ 70158-59-7 ]

2,5-Dichloro-3-(trifluoromethyl)pyridine

Similarity: 0.93

Chemical Structure| 211122-40-6

[ 211122-40-6 ]

5-Bromo-2-chloro-3-(trifluoromethyl)pyridine

Similarity: 0.84

Chemical Structure| 55304-75-1

[ 55304-75-1 ]

2,6-Dichloro-3-(trifluoromethyl)pyridine

Similarity: 0.84

Chemical Structure| 1211578-93-6

[ 1211578-93-6 ]

6-Chloro-5-(trifluoromethyl)pyridin-3-ol

Similarity: 0.83

Chemical Structure| 887707-25-7

[ 887707-25-7 ]

2-Chloro-5-iodo-3-(trifluoromethyl)pyridine

Similarity: 0.83

Related Parent Nucleus of
[ 65753-47-1 ]

Pyridines

Chemical Structure| 70158-59-7

[ 70158-59-7 ]

2,5-Dichloro-3-(trifluoromethyl)pyridine

Similarity: 0.93

Chemical Structure| 211122-40-6

[ 211122-40-6 ]

5-Bromo-2-chloro-3-(trifluoromethyl)pyridine

Similarity: 0.84

Chemical Structure| 55304-75-1

[ 55304-75-1 ]

2,6-Dichloro-3-(trifluoromethyl)pyridine

Similarity: 0.84

Chemical Structure| 1211578-93-6

[ 1211578-93-6 ]

6-Chloro-5-(trifluoromethyl)pyridin-3-ol

Similarity: 0.83

Chemical Structure| 887707-25-7

[ 887707-25-7 ]

2-Chloro-5-iodo-3-(trifluoromethyl)pyridine

Similarity: 0.83

; ;