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[ CAS No. 6386-38-5 ] {[proInfo.proName]}

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Chemical Structure| 6386-38-5
Chemical Structure| 6386-38-5
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Nadira De Abrew, K. ; Natoli, Ted ; Lester, Cathy C. , et al. DOI: PubMed ID:

Abstract: Butylated hydroxytoluene (BHT) is a synthetic antioxidant widely used in many industrial sectors. BHT is a well-studied compound for which there are many favorable regulatory decisions. However, a recent opinion by the French Agency for Food, Environmental and Occupational Health and Safety (ANSES) hypothesizes a role for BHT in endocrine disruption ANSES (2021). This opinion is based on observations in mostly rat studies where changes to thyroid physiol. are observed Enzymic induction of Cytochrome P 450-mediated thyroid hormone catabolism has been proposed as a mechanism for these observations, however, a causal relationship has not been proven. Other evidence proposed in the document includes a read across argument to butylated hydroxyanisole (BHA), another Community Rolling Action Plan (CoRAP)-listed substance with endocrine disruption concerns. We tested the hypothesis that BHT is an endocrine disruptor by using a Next Generation Risk Assessment (NGRA) method. Four different cell lines: A549, HCC1428, HepG2, and MCF7 were treated with BHT and a series of BHT analogs at 5 different concentrations, RNA was isolated from cell extracts and run on the L1000 gene array platform. A toxicogenomics-based assessment was performed by comparing BHT′s unique genomic signature to a large external database containing signatures of other compounds (including many known endocrine disruptors) to identify if any endocrine disruption-related modes of action (MoAs) are prevalent among BHT and other compounds with similar genomic signatures. In addition, we performed a toxicogenomics-based structure activity relationship (SAR) assessment of BHT and a series of structurally similar analogs to understand if endocrine disruption is a relevant MoA for chems. that are considered suitable analogs to BHT using the P&G read across framework (Wu et al., 2010). Neither BHT nor any of its analogs connected to compounds that had endocrine activity for estrogens, androgens, thyroid, or steroidogenesis.

Keywords: estrogen, androgen, or thyroid hormone receptors, or proteins integral to steroidogenesis (EATS) ; connectivity mapping ; toxicogenomics ; read across ; New Approach Methodologies (NAM) ; Next Generation Risk Assessment (NGRA)

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Product Details of [ 6386-38-5 ]

CAS No. :6386-38-5 MDL No. :MFCD00210461
Formula : C18H28O3 Boiling Point : -
Linear Structure Formula :HOC6H2(C(CH3)3)2C2H4CO2CH3 InChI Key :PXMJCECEFTYEKE-UHFFFAOYSA-N
M.W : 292.41 Pubchem ID :62603
Synonyms :

Safety of [ 6386-38-5 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 6386-38-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 6386-38-5 ]
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[ 6386-38-5 ] Synthesis Path-Upstream   1~2

  • 1
  • [ 6386-38-5 ]
  • [ 128-39-2 ]
  • [ 5597-50-2 ]
  • [ 36837-50-0 ]
Reference: [1] Patent: CN107011149, 2017, A, . Location in patent: Paragraph 0064-0067
  • 2
  • [ 6386-38-5 ]
  • [ 5597-50-2 ]
  • [ 36837-50-0 ]
  • [ 115-11-7 ]
Reference: [1] Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1987, vol. 36, # 4, p. 681 - 684[2] Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1987, # 4, p. 752 - 756
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