* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
b. 2-chloro-4-methyl-quinazoline Prepared analogously to Example 27c from 4-methyl-1H-quinazolin-2-one and phosphorus oxychloride in hydrochloric acid. Yield: 67percent of theory, Rf value: 0.81 (silica gel; petroleum ether/ethyl acetate=7:3).
Reference：
[1] Patent: US6200976, 2001, B1,
[2] Chemical Communications, 2014, vol. 50, # 33, p. 4302 - 4304
[3] Patent: WO2005/123714, 2005, A1, . Location in patent: Page/Page column 7
N-(2-(1H-indol-3-yl)ethyl)-4-methylquinazolin-2-amine[ No CAS ]
Yield
Reaction Conditions
Operation in experiment
50%
With potassium carbonate; In acetonitrile; at 160℃; for 1h;Microwave irradiation; Inert atmosphere;
General procedure: 4-Methyl-N-phenylquinazolin-2-amine (17a). A mixture of 16 (20 mg, 0.11 mmol), aniline (0.012 mL, 0.13 mmol) and K2CO3 (23 mg, 0.17 mmol) in CH3CN (0.90 mL) was placed in sealed vial. The mixture was heated using microwave irradiation at 160 °C for 1 h. The reaction mixture was filtered and concentrated and the residue was purified by chromatography on SiO2 (benzene/ether, 4:1) to afford 17a (17 mg, 65percent) as a yellow solid.
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