[ CAS No. 607-68-1 ] {[proInfo.proName]}

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Quality Control of [ 607-68-1 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 607-68-1 ]

SDS Specification

Alternatived Products of [ 607-68-1 ]

Product Details of [ 607-68-1 ]

CAS No. :	607-68-1	MDL No. :	MFCD00091950
Formula :	C₈H₄Cl₂N₂	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	TUQSVSYUEBNNKQ-UHFFFAOYSA-N
M.W :	199.04	Pubchem ID :	252886
Synonyms :

Calculated chemistry of [ 607-68-1 ] Expand+

Physicochemical Properties

Num. heavy atoms :	12
Num. arom. heavy atoms :	10
Fraction Csp3 :	0.0
Num. rotatable bonds :	0
Num. H-bond acceptors :	2.0
Num. H-bond donors :	0.0
Molar Refractivity :	49.56
TPSA :	25.78 ?2

Pharmacokinetics

GI absorption :	High
BBB permeant :	Yes
P-gp substrate :	No
CYP1A2 inhibitor :	Yes
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-4.94 cm/s

Lipophilicity

Log Po/w (iLOGP) :	2.28
Log Po/w (XLOGP3) :	3.62
Log Po/w (WLOGP) :	2.94
Log Po/w (MLOGP) :	2.43
Log Po/w (SILICOS-IT) :	3.21
Consensus Log Po/w :	2.9

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	1.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	-3.97
Solubility :	0.0213 mg/ml ; 0.000107 mol/l
Class :	Soluble
Log S (Ali) :	-3.85
Solubility :	0.0282 mg/ml ; 0.000142 mol/l
Class :	Soluble
Log S (SILICOS-IT) :	-4.57
Solubility :	0.00542 mg/ml ; 0.0000272 mol/l
Class :	Moderately soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	0.0 alert
Leadlikeness :	2.0
Synthetic accessibility :	1.54

Safety of [ 607-68-1 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P305+P351+P338	UN#:	N/A
Hazard Statements:	H302-H315-H319-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 607-68-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 607-68-1 ]
Downstream synthetic route of [ 607-68-1 ]

[ 607-68-1 ] Synthesis Path-Upstream 1~2

1
[ 607-68-1 ]
[ 75-24-1 ]
[ 6141-14-6 ]

Reference： [1] Tetrahedron Letters, 1996, vol. 37, # 8, p. 1309 - 1312
[2] Acta Chemica Scandinavica, 1997, vol. 51, # 3, p. 302 - 306

2
[ 607-68-1 ]
[ 676-58-4 ]
[ 6141-14-6 ]

Reference： [1] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 1, p. 417 - 422

[ 607-68-1 ] Synthesis Path-Downstream 1~12

1
[ 6789-94-2 ]
[ 607-68-1 ]
[ 730235-03-7 ]

Reference： [1]Journal of Medicinal Chemistry,1981,vol. 24,p. 127 - 140
[2]Journal of Medicinal Chemistry,1981,vol. 24,p. 127 - 140

2
[ 607-68-1 ]
[ 141-97-9 ]
[ 425638-74-0 ]

Yield	Reaction Conditions	Operation in experiment
54%		Lambda/, nu-dimethylaniline (33.4 g, 276 mmol, 1 .0 eq) was added dropwise to a solution of 2,4 (1 H, 3H)-quinazolinedione (50 g, 276 mmol, 1 .0 eq) in POCI3 (300 ml) and the mixture was heated to reflux for 3 hrs. The solution was cooled to room temperature, poured onto ice water and the resulting precipitate was filtered off and washed with water. The solid was dissolved in EtOAc and washed with water and brine. The organic fraction was dried over Na2S04, filtered, concentrated under reduced pressure, and washed with petroleum ether to give the corresponding dichloro-derivative (20 g, 34% yield).Ethyl-3-oxobutanoate (31.2 g, 240 mmol, 2.0 eq) was added dropwise to a suspension of NaH (6 g, 156 mmol, 1 .3 eq) in THF (520 ml) at 0 C. After stirring at 0 C for 1 h and removal of THF under reduced pressure, a solution of 2,4-dichloroquinazoline (24 g, 120 mmol, 1.0 eq) in toluene (350 ml) was added and the reaction mixture was heated to reflux for 30 min. After removal of toluene under reduced pressure, NH4OH (320 ml) was added. After stirring for 20 min, the mixture was concentrated to remove NH4OH. EtOAc (100 ml) and water (50 ml) were added to the mixture, that was filtered to give 2-(2- chloroquinazolin-4-yl)acetamide (14.4 g, 54 % yield).1 -Methylpiperazine (34 g, 339 mmol, 5.0 eq) was added to a solution of 2-(2- chloroquinazolin-4-yl)acetamide (14.4 g, 65 mmol, 1.0 eq) in NMP (250 ml) and stirred at 50 C for 30 min. After cooling to room temperature, EtOAc (100 ml) was added and the suspension was filtered to give 2-(2-(4-methylpiperazin-1 -yl)quinazolin-4-yl)acetamide (10.5 g, 55 % yield).fert-BuOK (215 ml_, 121 mmol, 3.0 eq) was added to a solution of 2-(2-(4-methylpiperazin- 1 -yl)quinazolin-4-yl)acetamide (10.5 g, 36.8 mmol, 1.0 eq) and Intermediate 2 (10.5 g, 40.5 mmol, 1.1 eq) in anhydrous THF (250 ml) at room temperature and the mixture was stirred for about 30 min, quenched with water, extracted with EtOAc, washed with brine, dried over Na2S04, concentrated and purified by column chromatography (silicagel) to give the methyl-ester of intermediate 8 (1 1 g, 60 % yield).
	With NaH; In tetrahydrofuran; aqueous NH4OH; ethyl acetate; toluene;	b) Ethyl acetoacetate (5.08 mL, 2.0 eq.) dissolved in THF (25 mL) is added dropwise to a suspension of NaH (60%, 1.04 g, 1.3 eq.) in THF (25 mL) at 0 C. The solution is stirred 30 min. at 0 C. and the solvent is evaporated. The residue is redissolved in toluene (125 mL) and 2,4-dicloro-quinazoline (4.0 g, 20.0 mmol) is added. The mixture is stirred 30 min. at reflux and the toluene is evaporated. The oily residue is redissolved in aqueous NH4OH 25% (80 mL) and stirred overnight at RT. All volatile materials are evaporated and the residue is taken up in AcOEt (80 mL). The suspension is heated at reflux for 15 min., cooled to 0 C. and filtered to afford 2-(2-chloro-quinazolin-4-yl)-acetamide as a white solid. EI-MS: 221 [M]+178; IR (KBr) numax 3302, 3138, 1681, 1542, 1388, 1287, 948, 771; 1 H NMR (DMS0, 400 MHz) 6 4.21 (s, 2H), 7.24 (br s, 1H), 7.75-7.84 (m, 2H), 7.97 (d, J=8.4 Hz, 1H), 8.08 (dd, J=8.4, 7.5 Hz, 1H), 8.34 (d, J=8.4 Hz, 1H)

Reference： [1]Journal of Medicinal Chemistry,2009,vol. 52,p. 6193 - 6196
[2]Journal of Medicinal Chemistry,2011,vol. 54,p. 6028 - 6039
[3]Patent: WO2013/4709,2013,A1 .Location in patent: Page/Page column 54-55
[4]Patent: US2003/69424,2003,A1

3
[ 52851-41-9 ]
[ 607-68-1 ]

Reference： [1]Bioorganic and Medicinal Chemistry,2010,vol. 18,p. 6404 - 6413

4
[ 607-68-1 ]
[ 1709-59-7 ]
4-((2-chloroquinazolin-4-yl)amino)-N,N-dimethylbenzenesulfonamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
55%	With palladium diacetate; sodium t-butanolate; XPhos; In toluene; tert-butyl alcohol; at 90℃; for 1h;Inert atmosphere;	General procedure: A mixture of 0.63mmol aryl chloride, 0.63mmol aniline, 1.89mmol t-BuONa, 0.19mmol 2-(dicyclohexylphosphino)-2?,4?,6?-triisopropylbiphenyl (X-Phos) and 0.03mmol Pd(OAc)2 in 6mL tert-butanol and 10mL toluene was stirred at 90C for 1h under an argon atmosphere. When the reaction was complete, the mixture was cooled to room temperature, diluted with water and subsequently extracted with dichloromethane. The extracts were combined, washed with saturated saline solution, and dried over anhydrous Na2SO4. The solvent was removed under vacuum, and the residue was purified by recrystallization from a mixture of dichloromethane and hexane.

Reference： [1]European Journal of Medicinal Chemistry,2014,vol. 71,p. 1 - 14

5
[ 607-68-1 ]
[ 1009033-87-7 ]
C₃₀H₂₀N₄ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
68%	With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In tetrahydrofuran; water; at 90℃; for 12h;	10.0 g (50.2 mmol) of 2,4-dichloroquinazoline, 31.1 g (110.5 mmol) of <strong>[1009033-87-7]4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)pyridine</strong> and 2.9 g (2.5 mmol) of tetrakis(triphenylphosphine)palladium [Pd(PPh3)4] were dissolvedin 200 ml of tetrahydrofuran (THF) as a solvent, a solution obtained by dissolving 27.8 g (200.9 mmol) of potassiumcarbonate (K2CO3) in 100 ml of water was added thereto, and the mixture was reacted at 90 C for 12 hours. Afterremoving the solvent under a reduced pressure, the obtained reactant was washed with water and methanol. The residuewas recrystallized with toluene, and the precipitated crystal was separated with a filter, washed with methanol and dried,obtaining 15.0 g of a white solid compound (a yield: 68 %). (calculation value: 436.51, measurement value: MS[M+1]436.86)

Reference： [1]Patent: EP2842954,2015,A1 .Location in patent: Paragraph 0115; 0116

6
[ 607-68-1 ]
[ 952514-79-3 ]
2,4-bis[4-(1-phenyl-1H-benzo[d]imidazol-2-yl)phenyl]quinazoline [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
71%	With palladium diacetate; potassium carbonate; triphenylphosphine; In 1,4-dioxane; water; at 100℃; for 12h;Inert atmosphere;	General procedure: 2,4-Dichloroquinazoline (5 g, 25 mmol), aryl-boronic acid, palladium acetate (113 mg, 0.5 mmol), triphenylphosphine (264 mg, 1 mmol) and potassium carbonate (10.4 g, 75.4 mmol) were suspended in a mixture of 1,4-dioxane (60 mL) and water (30 mL) in a three-necked, round-bottomed flask with tightly sealed. The mixture was stirred and heated at 100 C for 12 h under nitrogen atmosphere. After cooling to room temperature, CH2Cl2 (50 mL) and water (50 mL) were added. The aqueous layer was extracted with CH2Cl2 (3 x 20 mL). The combined organic layers were washed by brine (3 x 30 mL), dried over anhydrous sodium sulfate and solvents were removed under reduced pressure to yield the crude product as a light yellow solid, which was further purified by recrystallization (dichloromethane/ethanol) to give pureproduct. 2,4-Bis[4-(1-phenyl-1H-benzo[d]imidazol-2-yl)phenyl]quinazoline (BBIQz) was synthesized according to the general procedure from 2,4-dichloroquinazoline (5 g, 25 mmol) and 1 (55.4 mmol) in 71% isolated yield. 1H NMR (500 MHz, CDCl3, delta): 8.62 (d, J 8.5 Hz, 2H), 8.12 (d, J 8.5 Hz, 1H), 8.06 (d, J 8.5 Hz, 1H), 7.93 (t, J 7.0 Hz, 2H), 7.89 (t, J 7.5 Hz, 1H), 7.85-7.81 (m, 4H), 7.74 (d, J 9.5 Hz, 2H), 7.58-7.47 (m, 7H), 7.42-7.34 (m, 6H), 7.33-7.27 (m, 4H); 13CNMR (125 MHz, CDCl3, delta): 159.4, 152.1, 152.0, 151.5, 143.1, 143.1,138.9, 138.3, 137.5, 137.4, 137.0, 136.9, 133.9, 131.8, 131.6, 130.2, 130.1,130.0, 129.7, 129.5, 129.3, 128.9, 128.6, 128.5, 127.5, 127.5, 126.8, 123.7, 123.5, 123.3, 123.1, 121.6, 120.0, 120.0, 110.6, 110.5; MS (m/z,EI) Calcd for C46H30N6 666.25, found: 666.20. Anal. calcd. for C46H30N6: C 82.86, H 4.54, N, 12.60; Found: C 82.74, H 4.53, N, 12.61.

Reference： [1]Dyes and Pigments,2016,vol. 125,p. 299 - 308

7
[ 607-68-1 ]
[ 952514-79-3 ]
2-chloro-4-[4-(1-phenyl-1H-benzo[d]imidazol-2-yl)phenyl]quinazoline [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
79%	With palladium diacetate; potassium carbonate; triphenylphosphine; In 1,4-dioxane; water; at 100℃; for 12h;Inert atmosphere;	General procedure: 2,4-Dichloroquinazoline (5 g, 25 mmol), aryl-boronic acid, palladium acetate (113 mg, 0.5 mmol), triphenylphosphine (264 mg, 1 mmol) and potassium carbonate (10.4 g, 75.4 mmol) were suspended in a mixture of 1,4-dioxane (60 mL) and water (30 mL) in a three-necked, round-bottomed flask with tightly sealed. The mixture was stirred and heated at 100 C for 12 h under nitrogen atmosphere. After cooling to room temperature, CH2Cl2 (50 mL) and water (50 mL) were added. The aqueous layer was extracted with CH2Cl2 (3 x 20 mL). The combined organic layers were washed by brine (3 x 30 mL), dried over anhydrous sodium sulfate and solvents were removed under reduced pressure to yield the crude product as a light yellow solid, which was further purified by recrystallization (dichloromethane/ethanol) to give pureproduct.
53 g	With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In ethanol; water; toluene; for 16h;Reflux;	30 g of 2,4-dichloroquinazoline, 47.35 g of 4- (1-phenyl-1H-benzo[d] imidazol-2-yl) 1-phenyl-1H-benzo [d] imidazol-2-yl) phenylboronicacid, 8.7 g of tetrakis (triphenylphosphine) palladium, 450 ml of toluene, 66 ml of ethanol and 200 Ml of a 2M aqueous solution of potassiumcarbonate was added to a 500 ml flask and refluxed for 16 hours.The reactiongave a solid which wasquenched with water andthe solid separatedoff. Afterheating with toluene and dissolving in hexane, 53 g of a light yellow solid was obtained.
53 g	With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In ethanol; water; toluene; for 16h;Reflux;	30 g of 2,4-Dichloroquinazoline and 47.35 g of 4-(1-phenyl-1H-benzo[d]imidazol-2-yl)phenylboronic acid (4-( 1-phenyl-1H-benzo[d]imidazol-2-yl)phenylboronic acid), 8.7 g of tetrakis(triphenylphosphine)palladium, 450 ml of toluene, 66 ml of ethanol and 200 A mixture of 2 M aqueous solutions of potassium carbonate was added to a 500 ml flask and refluxed for 16 hours. The reaction resulted in the formation of a solid. After quenching the reaction with water, the solid was separated and dissolved by heating with toluene and precipitated with hexane to give 53 g of pale yellow solid.

Reference： [1]Dyes and Pigments,2016,vol. 125,p. 299 - 308
[2]Patent: CN106957272,2017,A .Location in patent: Paragraph 0086; 0087
[3]Patent: TWI603960,2017,B .Location in patent: Paragraph 0065; 0066

8
[ 607-68-1 ]
[ 952514-79-3 ]
4-[4-(1-phenyl-1H-benzo[d]imidazol-2-yl)phenyl]-2-[3-(triphenylen-2-yl)phen-3-yl]quinazoline [ No CAS ]

Reference： [1]Dyes and Pigments,2016,vol. 125,p. 299 - 308

9
[ 607-68-1 ]
[ 952514-79-3 ]
2-(9,9'-spirobifluorene-2'-yl)-4-[4-(1-phenyl-1H-benzo[d]imidazol-2-yl)phenyl]quinazoline [ No CAS ]

Reference： [1]Patent: CN106957272,2017,A
[2]Patent: TWI603960,2017,B

10
[ 607-68-1 ]
[ 256652-04-7 ]
2-chloro-4-(naphthalene-2-yl)quinazoline [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
49%	With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In tetrahydrofuran; water;	Acid pinacol ester Phenylboronic (19.2 g, 75.4 mmol), THF (332 ml), 2,4-dichloroquinazoline (15 g, 75.4 mmol), Pd (PPh 3 ) 4 (2.6 g, 2.26 mmol), K 2 CO 3 ( 31.2 g, 226 mmol), to give a water (166 ml) 9.64 g of the product using the Sub 1-1 synthesis. (Yield: 49%)

Reference： [1]Patent: KR2017/120233,2017,A .Location in patent: Paragraph 0514; 0519; 0520

11
[ 607-68-1 ]
[ 870774-25-7 ]
2-chloro-4-[4-(1-naphthalen-1-yl)phenyl]quinazoline [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
72%	With tetrakis(triphenylphosphine) palladium(0); sodium carbonate; In 1,4-dioxane; water; for 12h;Reflux;	The compound material (2.34 g, 11.9 mmol),Compound p-(4-indolyl)benzeneboronic acid (2.95 g, 11.9 mmol), Pd(PPh3)4(0.7 g, 0.59 mmol) and Na2CO3 (3.8 g, 35.7 mmol)After dissolving in a mixture of dioxane (55 mL) and distilled water (14 mL),The reaction was refluxed for 12 h. Then use PE/EA to pass the column,Get compound 3-5(3.14g, 8.57mmol, 72.0%)

Reference： [1]Patent: CN109553624,2019,A .Location in patent: Paragraph 0084; 0085; 0096; 0097

12
[ 607-68-1 ]
[ 870774-25-7 ]
C₆₀H₃₆N₄OS [ No CAS ]

Reference： [1]Patent: CN109553624,2019,A

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Technical Information

? Alkyl Halide Occurrence ? General Reactivity ? Grignard Reaction ? Hiyama Cross-Coupling Reaction ? Kinetics of Alkyl Halides ? Kumada Cross-Coupling Reaction ? Reactions of Alkyl Halides with Reducing Metals ? Reactions of Amines ? Stille Coupling ? Substitution and Elimination Reactions of Alkyl Halides ? Suzuki Coupling

Historical Records

Pharmaceutical Intermediates of
[ 607-68-1 ]

Sotrastaurin Related Intermediates

[ 425638-74-0 ]

2-(2-Chloroquinazolin-4-yl)acetamide

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[ 607-68-1 ]

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P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

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[ CAS No. 607-68-1 ] {[proInfo.proName]}

Quality Control of [ 607-68-1 ]

Related Doc. of [ 607-68-1 ]

Product Details of [ 607-68-1 ]

Calculated chemistry of [ 607-68-1 ] Expand+

Physicochemical Properties

Pharmacokinetics

Lipophilicity

Druglikeness

Water Solubility

Medicinal Chemistry

Safety of [ 607-68-1 ]

Application In Synthesis of [ 607-68-1 ]

[ 607-68-1 ] Synthesis Path-Upstream 1~2

[ 607-68-1 ] Synthesis Path-Downstream 1~12

Technical Information

Pharmaceutical Intermediates of [ 607-68-1 ]

Sotrastaurin Related Intermediates

Related Functional Groups of [ 607-68-1 ]

Chlorides

Related Parent Nucleus of [ 607-68-1 ]

Quinazolines

Precautionary Statements-General

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Inquiry

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[ 607-68-1 ]

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[ 607-68-1 ]

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[ 607-68-1 ]