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[ CAS No. 56187-47-4 ] {[proInfo.proName]}

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Chemical Structure| 56187-47-4
Chemical Structure| 56187-47-4
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Quality Control of [ 56187-47-4 ]

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Product Details of [ 56187-47-4 ]

CAS No. :56187-47-4 MDL No. :MFCD00864865
Formula : C18H15Cl2N5O5S3 Boiling Point : -
Linear Structure Formula :- InChI Key :VTLCNEGVSVJLDN-MLGOLLRUSA-N
M.W : 548.44 Pubchem ID :71736
Synonyms :
Refosporen;Cefazedonum
Chemical Name :(6R,7R)-7-(2-(3,5-Dichloro-4-oxopyridin-1(4H)-yl)acetamido)-3-(((5-methyl-1,3,4-thiadiazol-2-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Safety of [ 56187-47-4 ]

Signal Word:Danger Class:6.1
Precautionary Statements:P273-P281 UN#:2811
Hazard Statements:H302-H361-H410 Packing Group:Ⅲ
GHS Pictogram:

Application In Synthesis of [ 56187-47-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 56187-47-4 ]

[ 56187-47-4 ] Synthesis Path-Downstream   1~7

  • 1
  • [ 56187-37-2 ]
  • [ 30246-33-4 ]
  • [ 56187-47-4 ]
YieldReaction ConditionsOperation in experiment
93% With ortho-iodophenylboronic acid; In toluene;Reflux; 200ml of toluene and 2-iodophenylboronic acid (0.21mol) were added to a clean reaction flask, then compound IV210.93g (1.06mol) was added, and then compound III327.21g (0.95mol) was slowly added, and the reaction was refluxed for 5-6h, After the reaction, cooled to room temperature, transferred to purified water, separated the solid and filtered, washed with purified water, recrystallized with ethanol, and dried under vacuum to obtain 484.55 g of cefoxidone (I), with a molar yield of 93% and a purity of 99.9 %,Maximum single impurity 0.04%
  • 2
  • [ 56187-37-2 ]
  • [ 56187-47-4 ]
  • 3
  • 3-deacetyloxy-7-aminocephalosporanic acid [ No CAS ]
  • [ 56187-47-4 ]
  • 4
  • C15H12BrCl2N3O5S [ No CAS ]
  • [ 29490-19-5 ]
  • [ 56187-47-4 ]
YieldReaction ConditionsOperation in experiment
93.86% With triethylamine; In ethanol; for 10h;Reflux; In a 1 L round bottom flask,Add 800ml absolute ethanol,Triethylamine 1.012g, heated to reflux.Compound V46.39g was dissolved,2-mercapto-5-methyl-1,3,4-thiadiazole 12.30g,Stirring reaction 10h,After the reaction,Remove the solvent,Extraction with chloroform (3 x 250 ml)Then washed with a small amount of water extraction twice,Then dried over anhydrous magnesium sulphate overnight.After removing the solvent,The crude product is recrystallized from petroleum ether,48.08 g of a solid was obtained,Yield 93.86%HPLC purity 99.58%.
  • 5
  • [ 56187-47-4 ]
  • [ 63521-15-3 ]
YieldReaction ConditionsOperation in experiment
95.2% Add 50 ml of anhydrous methanol to a 100 ml three-necked flask, cool to 0~10 C, and add cefotaxime acid solids while stirring.(purchased from Shandong Hengxin Pharmaceutical Co., Ltd., article number 08C1251711012) 10.0 g, then add 2.0 g of triethylamine, stir until dissolved. The mixture was stirred under controlled temperature for 0.5 hours, and the mixture was filtered through an organic filter.The filtrate was transferred to a 1000 ml three-necked flask and the temperature was controlled at 0~10 C.A solution of sodium isooctanoate in acetone (3.0 g / 20 ml) was added dropwise with stirring.After about 0.5 hour, the 580 ml of acetone was added dropwise, and the mixture was dropped in about 1 hour. Then control the temperature 0~10 C, continue to stir for 2 hours. After suction filtration,Wash with acetone, vacuum dry at 25 C to obtain 9.9 g of solid,That is, cefotaxime sodium crystals. The yield was 95.2%. The purity was 99.90% by HPLC, the total impurity content was 0.1%, and the single impurity content was less than 0.05%.The water content is 0.32%.
95.2% The following examples are for explaining the embodiments of the present invention and are not intended to limit the present invention. Add 50 ml of anhydrous methanol to 100 ml of a three-necked flask, Cefazedone solid (Shandong Hengxin Pharmaceutical Co., Ltd.,) while stirring by lowering the temperature to 0 ~ 10 Add 10.0 g of product number 08C1251711012), Add more triethylamine 2.0 g, Stir until completely dissolved. After stirring for 30 minutes while controlling the temperature, The mixture is filtered through an organic filtration membrane, Transfer the filtrate to a 1000 ml three-necked flask and control the temperature at 0 ~ 10 , While stirring, an acetone solution (3.0 g/20 ml) of sodium isooctanoate was dropped for about 30 minutes, and 580 ml of acetone was dropped over about 1 hour. And the temperature is controlled to 0 ~ 10 , and the stirring is continued for 2 hours. Filtered again, washed with acetone, dried in vacuo at a temperature of 25 C. and solid, That is, 9.9 g of crystals of <strong>[56187-47-4]cefazedone</strong> sodium are obtained. The yield of crystals was 95.2%, the purity was 99.90% as a result of HPLC measurement, the total impurity content was 0.1%, and the single impurity content was all less than 0.05%, The water content is 0.32%. Through the above method, the X-ray powder diffraction pattern, differential scanning calorimetry curve, and thermogravimetric analysis curve of the crystalline form were measured.
  • 6
  • [ 957-68-6 ]
  • [ 56187-47-4 ]
  • 7
  • C12H13Cl2NO4 [ No CAS ]
  • C11H12N4O3S3*ClH [ No CAS ]
  • [ 56187-47-4 ]
YieldReaction ConditionsOperation in experiment
95% With triethylamine; In acetonitrile; at 0 - 5℃; for 0.5h;pH 6.8; Compound 294.32g (0.773mol),250ml acetonitrile was added to the reactor in sequence,Stir at room temperature and control the temperature at 0-5 C.Slowly add compound 260.13g (0.85mol),During the reaction, triethylamine was continuously added to control the pH to about 6.8.After stirring for 0.5h,Add ethyl acetate for crystallization, suction filtration,Dried in vacuo to obtain 402.75 g of cefoxidone (I),Product yield is 95%,The purity is 99.91%, and the maximum single impurity is 0.06%.
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