天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

Home Cart 0 Sign in  

[ CAS No. 53617-35-9 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
Chemical Structure| 53617-35-9
Chemical Structure| 53617-35-9
Structure of 53617-35-9 * Storage: {[proInfo.prStorage]}

Please Login or Create an Account to: See VIP prices and availability

Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Search after Editing

* Storage: {[proInfo.prStorage]}

* Shipping: {[proInfo.prShipping]}

Quality Control of [ 53617-35-9 ]

Related Doc. of [ 53617-35-9 ]

Alternatived Products of [ 53617-35-9 ]
Product Citations

Product Details of [ 53617-35-9 ]

CAS No. :53617-35-9 MDL No. :MFCD03274733
Formula : C9H18N2O Boiling Point : No data available
Linear Structure Formula :- InChI Key :-
M.W : 170.25 Pubchem ID :-
Synonyms :

Safety of [ 53617-35-9 ]

Signal Word:Warning Class:
Precautionary Statements:P261-P305+P351+P338 UN#:
Hazard Statements:H315-H319-H335 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 53617-35-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 53617-35-9 ]

[ 53617-35-9 ] Synthesis Path-Downstream   1~7

  • 1
  • [ 454-16-0 ]
  • [ 53617-35-9 ]
  • 4-(1-(2-methoxy-4-nitrophenyl)piperidin-4-yl)morpholine [ No CAS ]
YieldReaction ConditionsOperation in experiment
With potassium carbonate; In acetonitrile; at 100℃; <strong>[454-16-0]1-fluoro-2-methoxy-4-nitrobenzene</strong> (5000 mg, 29.22 mmol), 4-(piperidin-4-yl)morpholine (4974 mg, 29.22 mmol), potassium carbonate (80764 mg, 58.44 mmol) in acetonitrile (45 ml) was stirred at 100° C. for overnight. The reaction was diluted with ethyl acetate, washed with water, dried, concentrated and purified by flash chromatography (silica gel) to provide 4-(1-(2-methoxy-4-nitrophenyl)piperidin-4-yl)morpholine. LCMS-ESI+ (m/z): [M+H]+ calcd for C16H23N3O4: 321.4. found: 322.0
  • 2
  • [ 939-69-5 ]
  • [ 53617-35-9 ]
  • C21H25N4O4S2(1-)*K(1+) [ No CAS ]
  • 3
  • [ 50-00-0 ]
  • [ 939-69-5 ]
  • [ 53617-35-9 ]
  • 6-hydroxy-7-[[4-(morpholin-4-yl)piperidin-1-yl]methyl]-1,3-benzothiazole-2-carbonitrile [ No CAS ]
  • 4
  • 9-ethyl-8-(trifluoroacetyloxy)-6,6-dimethyl-11-oxo-5H,6H-benzo[b]carbazole-3-carbonitrile [ No CAS ]
  • [ 53617-35-9 ]
  • [ 1256580-46-7 ]
YieldReaction ConditionsOperation in experiment
81.9% To a 100 mL three-necked flask was added 1.70 g (0.01 mol) of 4- (4-piperidinyl) morpholine and 40 mL of anhydrous tetrahydrofuran, and after cooling to 0 to 5 C, To the system was slowly added 0.48 g (0.012 mol) of 60% sodium hydride. After stirring for 15 min, 3.30 g (0.007 mol) of Ethyl-6,6-dimethyl-8-trifluoroacetate-11-oxa-6-11-dihydro-5H-benzo [b] carbazole-3-carbonitrile was dissolved in 20 mL Tetrahydrofuran was added dropwise to the reaction system and the temperature was raised to room temperature. After stirring for 3 to 4 hours, 20 mL of water was added to the reaction solution to quench the reaction. The resulting solution was extracted three times with dichloromethane and the resulting organic phase was concentrated under reduced pressure to a solid precipitate which was recrystallized from a mixture of methanol / water = 1: 1 to give a white solid Alectinib, 2.77 g (0.006 mol).
  • 6
  • 9-ethyl-8-iodo-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile [ No CAS ]
  • [ 53617-35-9 ]
  • [ 1256580-46-7 ]
YieldReaction ConditionsOperation in experiment
92% With sodium methylate; In N,N-dimethyl-formamide; at 100℃; for 12.0h; 9-ethyl-8-iodo-6,6-dimethyl-11-oxo-5H,6H,11H-benzo[b]carbazole-3-carbonitril (5.0 g,Was dissolved in N, N-dimethylformamide (120 mL) and 4- (4-piperidinyl) morpholine (4.4 g, 26 mmol)(1.5 g, 28 mmol). The reaction mixture was stirred at 100 C for 12 hours. The reaction mixture was cooled to room temperature, water (45 mL) was added, cooledCrystallization was carried out at 0 C for 4 hours and filtered to give alectinib, a white solid (4.9 g) in 92% yield.
89% With sodium methylate; In toluene; at 100℃; for 10.0h; 9-Ethyl-6,6-dimethyl-8-iodo-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile(4.40 g, 10 mmol) was added to 30 ml of toluene.Add 4-(4-piperidinyl)morpholine (3.4 g, 20 mmol),Sodium methoxide (1.08 g, 20 mmol), reacted at 100 C for 10 h, cooled to room temperature.Add 20 ml of water, cool to -10 C for 3 hours, filter,Get alectinib (4.29g, 8.9mmol),Mass Spectrum (ESI): M/Z = 483.24 (M+H), purity 93%, yield 89%.
10.3 g With potassium tert-butylate; L-proline; In 1,4-dioxane; at 120℃; for 24.0h;Inert atmosphere; The 9-ethyl-8-iodo-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo [b] carbazole-3-carbonitrile obtained as the starting material ( 10.7g, 0.021mol)With 4- (4-piperidinyl) morpholine (8.3 g, 0.048 mol),Potassium tert-butoxide (108mg, 0.001mol),L-proline (105mg, 0.001mol) was dissolved in 1,4-dioxane under the protection of N2, and reacted at 120 C for 24h.After the reaction of the raw materials was detected by TLC, it was extracted three times with ethyl acetate, washed with saturated brine, dried over anhydrous sodium sulfate, and recrystallized with ethanol.Yield 10.3 g of white solid,Its reaction formula is as follows:
  • 7
  • 9-ethyl-6,6-dimethyl-8-hydroxy-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile [ No CAS ]
  • [ 53617-35-9 ]
  • [ 1256580-46-7 ]
YieldReaction ConditionsOperation in experiment
22.8 g With sulfuric acid; sodium hydrogensulfite; at 230℃; under 22502.3 Torr; 9-Ethyl-6,6-dimethyl-8-hydroxy-11-oxa-6,11-dihydro-5H-benzo[b] produced in Step HCarbazole-3-carbonitrile 9 (11.27 g, 3.77 mol) and 4-morpholin-4-yl-piperidine (16.8 g, 4.9 mol)After mixing, it is added to the reaction vessel.In the presence of 100 ml of 85% concentrated sulfuric acid solution, add the catalyst sodium bisulfite to fully mix and stir.Increase pressure to 3MPa, increase temperature to 230C,Condensation reaction occurs. After the reaction is complete, the mixture is cooled and cooled. Ethyl acetate is added for extraction 3 times. The aqueous phase is collected, and the precipitated solid is stirred and filtered. The filter cake is recrystallized to give 9-ethyl-6,6-dimethyl-8- (4-Morpholin-4-yl-piperidin-1-yl)-11-oxa-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile 10 (22.8 g, 8.7 Mol).
Recommend Products
Same Skeleton Products
Historical Records

Pharmaceutical Intermediates of
[ 53617-35-9 ]

Alectinib Related Intermediates

Chemical Structure| 13682-77-4

[ 13682-77-4 ]

Potassium trifluoro(vinyl)borate

Chemical Structure| 15861-36-6

[ 15861-36-6 ]

6-Cyanoindole

Chemical Structure| 4133-34-0

[ 4133-34-0 ]

7-Methoxy-3,4-dihydronaphthalen-2(1H)-one

Chemical Structure| 939-80-0

[ 939-80-0 ]

4-Chloro-3-nitrobenzonitrile

Chemical Structure| 40052-13-9

[ 40052-13-9 ]

3-tert-Butoxy-3-oxopropanoic acid

Related Parent Nucleus of
[ 53617-35-9 ]

Aliphatic Heterocycles

Chemical Structure| 1208090-98-5

[ 1208090-98-5 ]

4-(4-Methylpiperidin-4-yl)morpholine dihydrochloride

Similarity: 0.89

Chemical Structure| 412356-24-2

[ 412356-24-2 ]

trans-4-Morpholinocyclohexanamine dihydrochloride

Similarity: 0.88

Chemical Structure| 1228947-14-5

[ 1228947-14-5 ]

trans-4-Morpholinocyclohexanol

Similarity: 0.83

Chemical Structure| 1005-67-0

[ 1005-67-0 ]

4-Butylmorpholine

Similarity: 0.81

Chemical Structure| 1588441-09-1

[ 1588441-09-1 ]

trans-4-Morpholinocyclohexanol hydrochloride

Similarity: 0.81

Morpholines

Chemical Structure| 1208090-98-5

[ 1208090-98-5 ]

4-(4-Methylpiperidin-4-yl)morpholine dihydrochloride

Similarity: 0.89

Chemical Structure| 412356-24-2

[ 412356-24-2 ]

trans-4-Morpholinocyclohexanamine dihydrochloride

Similarity: 0.88

Chemical Structure| 1228947-14-5

[ 1228947-14-5 ]

trans-4-Morpholinocyclohexanol

Similarity: 0.83

Chemical Structure| 1005-67-0

[ 1005-67-0 ]

4-Butylmorpholine

Similarity: 0.81

Chemical Structure| 1588441-09-1

[ 1588441-09-1 ]

trans-4-Morpholinocyclohexanol hydrochloride

Similarity: 0.81

Piperidines

Chemical Structure| 1208090-98-5

[ 1208090-98-5 ]

4-(4-Methylpiperidin-4-yl)morpholine dihydrochloride

Similarity: 0.89

Chemical Structure| 20845-34-5

[ 20845-34-5 ]

1-Methyl-2-piperidinemethanol

Similarity: 0.76

Chemical Structure| 179474-79-4

[ 179474-79-4 ]

1-(3-Methoxypropyl)piperidin-4-amine

Similarity: 0.76

Chemical Structure| 136030-04-1

[ 136030-04-1 ]

(S)-(1-Methylpiperidin-2-yl)methanol

Similarity: 0.76

Chemical Structure| 68474-13-5

[ 68474-13-5 ]

(R)-(1-Methylpiperidin-2-yl)methanol

Similarity: 0.76

; ;