天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

Home Cart 0 Sign in  

[ CAS No. 52092-47-4 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
Chemical Structure| 52092-47-4
Chemical Structure| 52092-47-4
Structure of 52092-47-4 * Storage: {[proInfo.prStorage]}

Please Login or Create an Account to: See VIP prices and availability

Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Search after Editing

* Storage: {[proInfo.prStorage]}

* Shipping: {[proInfo.prShipping]}

Quality Control of [ 52092-47-4 ]

Related Doc. of [ 52092-47-4 ]

Alternatived Products of [ 52092-47-4 ]
Product Citations

Product Details of [ 52092-47-4 ]

CAS No. :52092-47-4 MDL No. :MFCD03092916
Formula : C5H3ClN2O2 Boiling Point : -
Linear Structure Formula :- InChI Key :YUBHMOQVHOODEI-UHFFFAOYSA-N
M.W : 158.54 Pubchem ID :259806
Synonyms :

Calculated chemistry of [ 52092-47-4 ]      Expand+

Physicochemical Properties

Num. heavy atoms : 10
Num. arom. heavy atoms : 6
Fraction Csp3 : 0.0
Num. rotatable bonds : 1
Num. H-bond acceptors : 3.0
Num. H-bond donors : 0.0
Molar Refractivity : 38.07
TPSA : 58.71 ?2

Pharmacokinetics

GI absorption : High
BBB permeant : Yes
P-gp substrate : No
CYP1A2 inhibitor : No
CYP2C19 inhibitor : No
CYP2C9 inhibitor : No
CYP2D6 inhibitor : No
CYP3A4 inhibitor : No
Log Kp (skin permeation) : -6.13 cm/s

Lipophilicity

Log Po/w (iLOGP) : 1.14
Log Po/w (XLOGP3) : 1.6
Log Po/w (WLOGP) : 1.64
Log Po/w (MLOGP) : 0.68
Log Po/w (SILICOS-IT) : -0.09
Consensus Log Po/w : 1.0

Druglikeness

Lipinski : 0.0
Ghose : None
Veber : 0.0
Egan : 0.0
Muegge : 1.0
Bioavailability Score : 0.55

Water Solubility

Log S (ESOL) : -2.21
Solubility : 0.98 mg/ml ; 0.00618 mol/l
Class : Soluble
Log S (Ali) : -2.44
Solubility : 0.57 mg/ml ; 0.00359 mol/l
Class : Soluble
Log S (SILICOS-IT) : -2.01
Solubility : 1.55 mg/ml ; 0.00979 mol/l
Class : Soluble

Medicinal Chemistry

PAINS : 0.0 alert
Brenk : 2.0 alert
Leadlikeness : 1.0
Synthetic accessibility : 1.99

Safety of [ 52092-47-4 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 52092-47-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 52092-47-4 ]

[ 52092-47-4 ] Synthesis Path-Downstream   1~11

  • 1
  • [ 1072-98-6 ]
  • [ 52092-47-4 ]
YieldReaction ConditionsOperation in experiment
71% With sulfuric acid; dihydrogen peroxide; at 20℃; for 48h; [01066] After conc. sulfuric acid (50 ml) was cooled with ice, 30percent aqueous solution of hydrogen peroxide (25 ml) was dropped thereto stirring, and then conc. sulfuric acid (50 ml) solution of 2-amino-5-chloropyridine (5.0 g, 38.9 mmol) was dropped thereto further and stirred for 48 hours at the room temperature. The reaction mixture was added into ice and filtered. The residue was recrystallized with ethanol to obtain 4.38 g (yield 71percent) of 5-chloro-2-nitoropyriine as a colorless powdery crystal.
With sulfuric acid; dihydrogen peroxide; at 0 - 20℃; for 20h; Step A: 5-Chloro-2-nitropyridine To concentrated H2SO4 (50 mL) was added 30 percent H202 (25 mL) at 0 °C and a solution of 5- chloropyridin-2-amine (5.0 g, 39 mmol) in concentrated H2S04 (20 mL) was added at 0 °C. The mixture was stirred for 20 hours at room temperature. The mixture was poured into ice water under vigorous stirring and the resulting solid was filtered. The solid was recrystallized from ethanol to give 5-chloro-2-nitropyridine. 1H-NMR (400MHz, CDC13) delta 8.58 (d, J=2.8 Hz, 1H), 8.23 (d, J=8.8 Hz, 1H), 8.00 (dd, J=2.8 Hz, 8.8Hz, 1H). LC/MS m/z 159 (M+l)+.
With sulfuric acid; dihydrogen peroxide; In water; at 20℃; for 20h; Step A: 5-chloro-2-nitropyridine: To concentrated H2SO4 (50 mL) was added 30 percent H2O2 (25 mL) at 0 °C and a solution of 5-chloropyridin-2-amine (5.0 g, 39 mmol) in concentrated H2SO4 (20 mL) at 0 °C. The mixture was stirred for 20 hours at room temperature. The mixture was poured into ice water under vigorous stirring and the resulting solid was filtered. The solid was recrystallized from ethanol to give 5-chloro-2-nitropyridine.
With sulfuric acid; dihydrogen peroxide; In water; at 0 - 20℃; for 20h; Step A: 5-chloro-2-nitropyridine: To concentrated H2SO4 (50 mL) was added 30 percent H202 (25 mL) at 0 °C and a solution of 5-chloropyridin-2-amine (5.0 g, 39 mmol) in concentrated H2S04 (20 mL) at 0 °C. The mixture was stirred for 20 hours at room temperature. The mixture was poured into ice water under vigorous stirring and the resulting solid was filtered. The solid was recrystallized from ethanol to give 5-chloro-2-nitropyridine.
With sulfuric acid; dihydrogen peroxide; at 0 - 20℃; for 20h; [0217] To concentrated H2SO4 (50 mL) was added 30 percent H2O2 (25 mL) at 0 °C and a solution of 5-chloropyridin-2-amine (5.0 g, 39 mmol) in concentrated H2SO4 (20 mL) was added at 0 °C. The mixture was stirred for 20 hours at roomtemperature. The mixture was poured into ice water under vigorous stirring and the resulting solid was filtered. The solidwas recrystallized from ethanol to give 5-chloro-2-nitropyridine. 1H-NMR (400MHz, CDCl3) delta 8.58 (d, J=2.8 Hz, 1H),8.23 (d, J=8.8 Hz, 1H), 8.00 (dd, J=2.8 Hz, 8.8Hz, 1H). LC/MS m/z 159 (M+1)+.

  • 2
  • [ 52092-47-4 ]
  • [ 141-52-6 ]
  • [ 22109-30-4 ]
  • 3
  • [ 52092-47-4 ]
  • [ 1072-98-6 ]
  • 6
  • [ 99848-04-1 ]
  • [ 52092-47-4 ]
  • 8
  • [ 52092-47-4 ]
  • [ 3167-49-5 ]
  • 10
  • [ 15128-91-3 ]
  • [ 52092-47-4 ]
  • 11
  • [ 101079-67-8 ]
  • [ 52092-47-4 ]
Recommend Products
Same Skeleton Products

Technical Information

Historical Records

Pharmaceutical Intermediates of
[ 52092-47-4 ]

Ribociclib Intermediates

Chemical Structure| 1211443-61-6

[ 1211443-61-6 ]

2-Chloro-7-cyclopentyl-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide

Chemical Structure| 571189-16-7

[ 571189-16-7 ]

tert-Butyl 4-(6-nitropyridin-3-yl)piperazine-1-carboxylate

Chemical Structure| 1374639-78-7

[ 1374639-78-7 ]

tert-Butyl 4-(6-((7-cyclopentyl-6-(dimethylcarbamoyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate

Chemical Structure| 733039-20-8

[ 733039-20-8 ]

5-Bromo-2-chloro-N-cyclopentylpyrimidin-4-amine

Chemical Structure| 1374639-77-6

[ 1374639-77-6 ]

(2-Chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)methanol

Related Functional Groups of
[ 52092-47-4 ]

Chlorides

Chemical Structure| 65370-42-5

[ 65370-42-5 ]

4-Chloro-2-nitropyridine

Similarity: 0.89

Chemical Structure| 1211532-85-2

[ 1211532-85-2 ]

5-Chloro-3-methyl-2-nitropyridine

Similarity: 0.88

Chemical Structure| 610278-88-1

[ 610278-88-1 ]

3,5-Dichloro-2-nitropyridine

Similarity: 0.83

Chemical Structure| 1064783-29-4

[ 1064783-29-4 ]

5-Chloro-3-fluoro-2-nitropyridine

Similarity: 0.80

Chemical Structure| 936247-35-7

[ 936247-35-7 ]

5-Chloro-2-nitropyridin-3-ol

Similarity: 0.79

Nitroes

Chemical Structure| 65370-42-5

[ 65370-42-5 ]

4-Chloro-2-nitropyridine

Similarity: 0.89

Chemical Structure| 1211532-85-2

[ 1211532-85-2 ]

5-Chloro-3-methyl-2-nitropyridine

Similarity: 0.88

Chemical Structure| 610278-88-1

[ 610278-88-1 ]

3,5-Dichloro-2-nitropyridine

Similarity: 0.83

Chemical Structure| 1064783-29-4

[ 1064783-29-4 ]

5-Chloro-3-fluoro-2-nitropyridine

Similarity: 0.80

Chemical Structure| 936247-35-7

[ 936247-35-7 ]

5-Chloro-2-nitropyridin-3-ol

Similarity: 0.79

Related Parent Nucleus of
[ 52092-47-4 ]

Pyridines

Chemical Structure| 65370-42-5

[ 65370-42-5 ]

4-Chloro-2-nitropyridine

Similarity: 0.89

Chemical Structure| 1211532-85-2

[ 1211532-85-2 ]

5-Chloro-3-methyl-2-nitropyridine

Similarity: 0.88

Chemical Structure| 610278-88-1

[ 610278-88-1 ]

3,5-Dichloro-2-nitropyridine

Similarity: 0.83

Chemical Structure| 1064783-29-4

[ 1064783-29-4 ]

5-Chloro-3-fluoro-2-nitropyridine

Similarity: 0.80

Chemical Structure| 936247-35-7

[ 936247-35-7 ]

5-Chloro-2-nitropyridin-3-ol

Similarity: 0.79

; ;