天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

Home Cart 0 Sign in  

[ CAS No. 49609-84-9 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
HazMat Fee +

There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Chemical Structure| 49609-84-9
Chemical Structure| 49609-84-9
Structure of 49609-84-9 * Storage: {[proInfo.prStorage]}

Please Login or Create an Account to: See VIP prices and availability

Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Search after Editing

* Storage: {[proInfo.prStorage]}

* Shipping: {[proInfo.prShipping]}

Quality Control of [ 49609-84-9 ]

Related Doc. of [ 49609-84-9 ]

Alternatived Products of [ 49609-84-9 ]
Product Citations

Product Details of [ 49609-84-9 ]

CAS No. :49609-84-9 MDL No. :MFCD00051677
Formula : C6H3Cl2NO Boiling Point : -
Linear Structure Formula :NC5H3(Cl)COCl InChI Key :RXTRRIFWCJEMEL-UHFFFAOYSA-N
M.W : 176.00 Pubchem ID :2774541
Synonyms :

Safety of [ 49609-84-9 ]

Signal Word:Danger Class:8
Precautionary Statements:P280-P305+P351+P338-P310 UN#:3261
Hazard Statements:H314 Packing Group:Ⅱ
GHS Pictogram:

Application In Synthesis of [ 49609-84-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 49609-84-9 ]

[ 49609-84-9 ] Synthesis Path-Downstream   1~9

  • 1
  • [ 39745-40-9 ]
  • [ 49609-84-9 ]
  • [ 866421-53-6 ]
  • 2
  • [ 49609-84-9 ]
  • [ 133627-45-9 ]
  • [ 133627-46-0 ]
YieldReaction ConditionsOperation in experiment
With potassium carbonate; In ethyl acetate; at 75 - 80℃; for 14h;Product distribution / selectivity; Example-3: Preparation of 2-Chloro-N-(2-chloro-4-methyl-3-pyridinyl)-3 -pyridine carboxamide (V) [utilizing ethyl acetate as solvent during acylation]2-Chloro nicotinic acid (1.33kg; 8.44moles) was added to toluene (S.Olitres) and thionyl chloride (0.75 litres; 10.42 moles) and dimethyl formamide (100ml; 0.18moles) were added and the mixture refluxed at 80C-90C till completion of reaction. The reaction mixture was concentrated under reduced pressure and cooled between 25C and 300C. Ethyl acetate (8.0 litres) was added to the mixture followed by potassium carbonate (2.0kg; 15.15 moles). 3-Amino-2-chloro-4-methyl pyridine of formula (IIotaI).was dissolved in ethyl acetate and added to the acid chloride (IV). The mixture was refluxed at 75C to 8O0C for 14 hours. The reaction mixture was concentrated after completion of the reaction and water (5.0 litres) was added. The reaction mass was cooled between 10-150C, filtered and dried between 600C and 700C under reduced pressure..Yield: 1.73 kg. % Yield: 87.80%. HPLC Purity: 99.9%.
With potassium carbonate; In toluene; at 75 - 80℃; for 14h;Product distribution / selectivity; Example-4: Preparation of 2-Chloro-N-(2-chloro-4-methyl-3-pyridinyl)-3 -pyridine carboxamide (V) [utilizing toluene as solvent and potassium carbonate as inorganic base during acylation]2-Chloro nicotinic acid (1.33kg; 8.44moles) was added to toluene (5.01itres) and thionyl chloride (0.75 litres; 10.42 moles) and dimethyl formamide (100ml; 0.18moles) were added and the mixture refluxed at 800C -9O0C till completion of reaction. The reaction EPO <DP n="20"/>mixture was concentrated under reduced pressure and cooled between 25C and 300C. Toluene (8.0 litres) was added to the residue containing compound (IV), followed by addition of potassium carbonate (2.0kg; 15.15 moles). 3-Amino-2-chloro-4-methyl pyridine of formula (III) dissolved in toluene was added to the acid chloride (IV). The mixture was refluxed at 750C to 800C for 14 hours. The reaction mixture was concentrated after completion of the reaction and quenched with water (5.0 litres). The reaction mass was cooled between 10-150C and filtered.Yield: 1.73 kg. % Yield: 87.80%. HPLC Purity: 99.9%.
With triethylamine; In toluene; at 25 - 32℃;Product distribution / selectivity; Example-5: Preparation of 2-Chloro-N-(2-chloro-4-methyl-3-pyridinyl)-3 -pyridine carboxamide (V) [utilizing toluene as solvent during acylation and triethyl amine as organic base]2-Chloro nicotinic acid (1.33kg; 8.44moles) was added to toluene (5.01itres) and thionyl chloride (0.75 litres; 10.42 moles) and dimethyl formamide (100ml; 0.18moles) were added and the mixture refluxed at 800C -9O0C till completion of reaction. The reaction mixture was concentrated under reduced pressure. Toluene (8.0 litres) was added to the mixture. 3-Amino-2-chloro-4-methyl pyridine of formula (III) dissolved in toluene was added to the acid chloride (IV) and triethyl amine was added to the reaction mixture to adjust pH. The mixture was stirred at 250C to 32C. Impurity formation up to 30-40% was formed in the reaction mixture, therefore, the reaction was not worked up for isolation of compound (V).
With pyridine; In 1,4-dioxane; cyclohexane; at 25 - 32℃; for 2.5h;Product distribution / selectivity; Example 6: Preparation of 2-Chloro-N-(2-chloro-4-methyl-3-pyridinyl)-3-pyridine carboxamide (V) [utilizing toluene as solvent during acylation and pyridine as organic base]2-Chloro nicotinic acid (41.5gms; 0.263moles) was added to toluene (125ml) and thionyl chloride (19ml; 0.26moles) and dimethyl formamide (2.5ml; 0.005moles) were added and the mixture refluxed at 800C -900C till completion of reaction. The reaction mixture was concentrated under reduced pressure and the residue diluted with dioxane (55ml). Pyridine (62.5ml; 0.77moles) was added to a mixture of 3-Amino-2-chloro-4-methyl pyridine of formula (111) stirred in cyclohexane (62.5ml). The acid chloride (IV) mixture in dioxane, EPO <DP n="21"/>was added to the mixture containing (III) and stirred for 2.5 hours at 25C to 32C. TLC monitoring of the reaction mixture showed lot of impurities. The solid separating out was filtered washed with cyclohexane. Compound (V) was dissolved in acetone (300ml), refiuxed, and concentrated to 50ml. The mixture was cooled between 5 and 100C, filtered and dried.Yield: 32gms % Yield: 64.9%.
With N,N-dimethyl-aniline; In toluene; at 25 - 40℃; for 2.5h;Product distribution / selectivity; Example 11: Preparation of 2-Chloro-N-(2-chloro-4-methyl-3-pyridinyl)-3-pyridine carboxamide (V) [utilizing toluene as solvent and N,N-dimethyl aniline as organic base during acylation]2-Chloro nicotinic acid (165.75gms; 1.057moles) was added to toluene (542gms) and thionyl chloride (56.40gms; 0.477moles) and dimethyl formamide (5.9gms; 0.080moles) were added and the mixture refluxed at 80C-90C till completion of reaction. The reaction mixture was concentrated under reduced pressure and the residue diluted with toluene (542gms). 3-Amino-2-chloro-4-methyl pyridine (125gms; 0.877moles) of formula (III) was added to the mixture containing compound of formula (IV) at ambient temperature followed by addition of N,N-dimethyl aniline (127.12gms; 1.05moles). The reaction mixture was stirred for 2.5 hours at 250C to 4O0C. After completion of reaction, the reaction mixture was cooled to ambient temperature and neutralized with 10% sodium carbonate solution to pH 7.0 to 7.5. The solid separating out was filtered, washed with toluene and dried. Yield: 220-230 gms % Yield: 89-93%. Purity: 99%
With pyridine; In 1,4-dioxane; cyclohexane; at 20℃; for 48h;Product distribution / selectivity; 2-Chloro-N-(2-chloro-4-methyl-pyridin-3-yl)-nicotinamide: The procedure is carried out as described in Hargrave J. Med. Chem. 1991, 34, 2231-2241, which is hereby incorporated by reference in its entirety. To a solution of <strong>[133627-45-9]3-amino-2-chloro-4-methylpyridine</strong> (18.2 mmol) in 6:1 cyclohexane-dioxane (6 mL), and pyridine (5.75 mL) is added a solution of 2-chloronicotinoyl chloride (12.8 mmol) in 1,4-dioxane (5 mL). The resulting mixture is stirred at ambient temperature for 48 hours and the precipitate is filtered and washed with water. The solid is taken up in ethanol (17.5 mL) and aqueous NaOH (0.1 N, 3.6 mL). The solution is then heated to reflux for 2 hours, cooled to ambient temperature and stirred overnight. The solvent is removed under vacuum and water (10 mL) is added to residue, with stirring. The mixture is cooled to 1OC and the crystalline product is filtered, washed with cold water and dried under vacuum to give the desired product, 2-chloro-N-(2-chloro-4-methyl-pyridin-3-yl)-nicotinamide.
With pyridine; In acetonitrile; at 20 - 45℃;Product distribution / selectivity; Step 3[00287] 2-Chloro-N-(2-chloro-4-methyl-pyridin-3-ylVnicotinamide: Pyridine (125 g, 1.58 mol, 1.10 equiv) was added to a solution of 2-chloro-4-methyl-pyridin-3-ylamine (204.6 g, 1.44 mol, 1.00 equiv) in acetonitrile (1500 ml) in a 2 liter 3 -necked round-bottom flask. 2- chloronicotinoyl chloride (270 g, 1.54 mol, 1.07 equiv) was added dropwise to the solution while maintaining the temperature at 20 C. The solution was allowed to react overnight while maintaining the temperature at 45 C in an oil bath. The solution was then diluted with water (2 L) and sodium carbonate was added till the pH of the solution reached 8. The solution was filtered, the filter cake was washed with water (100mLx3), and the filter cake was dissolved in tetrahydrofuran (3 L). The solution was decolorized by the addition of active carbon, and then filtered. The filtrate was then dried over sodium sulfate, concentrated in vacuo using a rotary evaporator. The product of 2-chloro-lambda/-(2-chloro-4-methyl-pyridin-3-yl) nicotinamide (32Og, purity: 94%, yield:79%) was obtained as a light red solid. The material was used in next step without further purification.

  • 3
  • [ 49609-84-9 ]
  • [ 5121-34-6 ]
  • [ 1026100-07-1 ]
  • 4
  • [ 49609-84-9 ]
  • [ 2343-22-8 ]
  • [ 931105-48-5 ]
YieldReaction ConditionsOperation in experiment
79% With triethylamine; In acetonitrile; at 23℃; for 16h; Example 22; 2-(4-(1H-Pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluorophenylamino)pyridin-3-yl)(5-fluoroindolin-1-yl)methanone, dihydrochloride salt; A) (2-Chloropyridin-3-yl)-(5-fluoroindolin-1-yl)methanone; 2-Chloronicotinoyl chloride (200 mg, 1.14 mmol) was dissolved in CH3CN (5.6 mL). 5-Fluoroindoline (171 mg, 1.25 mmol) was added followed by triethylamine (0.24 mL, 1.71 mmol) and the reaction mixture was stirred at 23 C. for 16 h. The solvent was removed by evaporation and the residue was partitioned between CH2Cl2 (10 mL) and sat. aq. NaHCO3 solution (10 mL). The organic phase was removed and the aqueous phase was extracted with CH2Cl2 (2×10 mL). The combined organics were dried over Na2SO4 and concentrated in vacuo. Flash column chromatography (40 g SiO2, 2% CH3OH-CH2Cl2) afforded the desired product as an off-white solid (247.8 mg, 79%). 1H NMR (DMSO-d6) δ 3.14 (t, 2H, J=8.39 Hz), 3.82 (t, 2H, J=8.39 Hz), 7.09 (dt, 1H, J=9.03, 2.80 Hz,), 7.20 (dd, 1H, J=8.39, 2.80 Hz), 7.60 (dd, 1H, J=7.38, 4.83 Hz), 8.10 (dd, 1H, J=7.63, 2.03 Hz), 8.15 (dd, 1H, J=8.90, 4.83 Hz), 8.55 (dd, 1H, J=4.83, 1.78 Hz).
  • 5
  • [ 49609-84-9 ]
  • [ 63655-40-3 ]
  • 2-chloro-N-(5-cyano-1H-benzimidazol-2-yl)-nicotinamide [ No CAS ]
  • 7
  • [ 49609-84-9 ]
  • [ 5369-19-7 ]
  • [ 64794-30-5 ]
YieldReaction ConditionsOperation in experiment
With potassium carbonate; In dichloromethane; water; at 0 - 20℃; for 2h; Example 2; Synthesis of N-(3-tert-butylphenyl)-1-(5-chloro-3-methylpicolinoyl)-2-phenylpiperidine-3-carboxamide; a) 2-Chloronicotinoyl chloride (1.05 eq) dissolved in anhydrous dichloromethane (0.5 M) was added to a solution of <strong>[5369-19-7]3-tert-butylaniline</strong> (1 eq) and 2 M aq K2CO3 (2.2 eq) in anhydrous dichloromethane (0.5 M) at 0° C. over a period of 30 min, and the reaction mixture was allowed to stir at room temperature for an additional 1.5 h. The layers were separated and the aqueous layer was extracted with dichloromethane. The combined organic layer was washed with brine, dried (MgSO4), filtered and concentrated to give the desired amide as a foamy solid which was used as such in the next step without further purification. MS: (ES) m/z 289.1 (M+H+).
  • 8
  • [ 49609-84-9 ]
  • [ 436-77-1 ]
  • 7-O-(2-chloronicotinoyl)-fangchinoline [ No CAS ]
YieldReaction ConditionsOperation in experiment
49% General procedure: Fangchinoline (100 mg, 0.16 mmol) was dissolved in 8 mL of CH2Cl2. The mixture was cooled to 0 C under N2. Pyridine (25 mg, 0.32 mmol) was added to the mixture. The solution was stirred for 1 h and various types of acyl chlorides (0.24 mmol, in 2 mL of CH2Cl2) were added dropwise over 10 min. The mixture was stirred for 1 h at 0 C and was stirred another hour at room temperature. The mixture was washed with water, dried over anhydrous Na2SO4 and filtered. After being concentrated under vacuum, the residue was purified by flash chromatography on silica gel using CH2Cl2/CH3OH as eluant to afford the desired products 6a-6p.
  • 9
  • [ 49609-84-9 ]
  • [ 1496-40-8 ]
  • 2-chloro-N-(2-(piperidin-1-yl)-5-(trifluoromethyl)phenyl)nicotinamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
78% With triethylamine; In dichloromethane; at 0 - 20℃; for 3h; General procedure: A 25 mL round bottom flask initiallyplaced in an ice bath was charged with 0.629 g (3.389 mmol) ofisonicotinoyl chloride hydrochloride, 0.800 mL of triethylamine,8.00 mL of dichoromethane and 0.400 (1.64 mmol) of 2-(piperidin-1-yl)-5-(trifluoromethyl) aniline (8). The ice-bathwas removed andthe mixture was magnetically stirred at room temperature for 3 h.Then, 10.0 mL of distilled water was added, and the mixture wastransferred to a separatory funnel. The aqueous layer was extractedwith ethyl acetate (4 x 30.0 mL). The organic extracts were combinedand the resulting organic layer was washed with brine, driedover sodium sulphate, filtered, and concentrated under reducedpressure. The residue was purified by silica gel column chromatographyeluted with hexane-ethyl acetate (3:1 v/v). The solid wasfurther recrystallized with acetone. The compound SRPIN340 wasobtained as a white solid in 75% yield (430 mg, 1.23 mmol).
Recommend Products
Same Skeleton Products

Technical Information

Historical Records

Similar Product of
[ 49609-84-9 ]

Chemical Structure| 121495-79-2

A1360639[ 121495-79-2 ]

2-Chloronicotinoyl chloride hydrochloride

Reason: Free-salt

Related Functional Groups of
[ 49609-84-9 ]

Chlorides

Chemical Structure| 176433-51-5

[ 176433-51-5 ]

2-Chloro-5-formylnicotinoyl chloride

Similarity: 0.98

Chemical Structure| 58584-83-1

[ 58584-83-1 ]

2,6-Dichloronicotinoyl chloride

Similarity: 0.98

Chemical Structure| 176433-64-0

[ 176433-64-0 ]

6-Chloro-5-formylnicotinoyl chloride

Similarity: 0.96

Chemical Structure| 50839-95-7

[ 50839-95-7 ]

2-Chloro-4-methylnicotinoyl chloride

Similarity: 0.93

Chemical Structure| 78686-87-0

[ 78686-87-0 ]

2,5-Dichloronicotinoyl chloride

Similarity: 0.93

Acyl Chlorides

Chemical Structure| 176433-51-5

[ 176433-51-5 ]

2-Chloro-5-formylnicotinoyl chloride

Similarity: 0.98

Chemical Structure| 58584-83-1

[ 58584-83-1 ]

2,6-Dichloronicotinoyl chloride

Similarity: 0.98

Chemical Structure| 176433-64-0

[ 176433-64-0 ]

6-Chloro-5-formylnicotinoyl chloride

Similarity: 0.96

Chemical Structure| 50839-95-7

[ 50839-95-7 ]

2-Chloro-4-methylnicotinoyl chloride

Similarity: 0.93

Chemical Structure| 78686-87-0

[ 78686-87-0 ]

2,5-Dichloronicotinoyl chloride

Similarity: 0.93

Related Parent Nucleus of
[ 49609-84-9 ]

Pyridines

Chemical Structure| 176433-51-5

[ 176433-51-5 ]

2-Chloro-5-formylnicotinoyl chloride

Similarity: 0.98

Chemical Structure| 58584-83-1

[ 58584-83-1 ]

2,6-Dichloronicotinoyl chloride

Similarity: 0.98

Chemical Structure| 176433-64-0

[ 176433-64-0 ]

6-Chloro-5-formylnicotinoyl chloride

Similarity: 0.96

Chemical Structure| 50839-95-7

[ 50839-95-7 ]

2-Chloro-4-methylnicotinoyl chloride

Similarity: 0.93

Chemical Structure| 78686-87-0

[ 78686-87-0 ]

2,5-Dichloronicotinoyl chloride

Similarity: 0.93

; ;