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CAS No. : | 496-42-4 | MDL No. : | MFCD05181726 |
Formula : | C10H12N2 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | WRAUXDQDRDJTKM-UHFFFAOYSA-N |
M.W : | 160.22 | Pubchem ID : | 439752 |
Synonyms : |
|
Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P280-P305+P351+P338-P310 | UN#: | N/A |
Hazard Statements: | H302-H315-H319-H332-H335 | Packing Group: | N/A |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
40% | General procedure: A suspension of alkynoic acids 1 (0.6 mmol), amine nucleophiles 2 or 3 (0.5 mmol), andAuPPh3Cl/AgSbF6 (with the amount indicated) in H2O (4.0 mL) was stirred at the temperatureindicated for 20 h. Then the reaction mixture was cooled to room temperature, and CF3COOH(0.5 mmol) was added, and the resulting mixture was stirred for another 4 h at the temperatureindicated. At ambient temperature, saturated Na2CO3 solution (25.0 mL) was added to the reactionmixture. The resulting mixture was then extracted with ethyl acetate (3 15 mL). The combinedorganic layers were washed with brine, and dried over Na2SO4. After filtration and removal of thesolvents in vacuo, the crude product was purified by flash chromatography on silica gel to yield thedesired product. |
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