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Quality Control of [ 4333-56-6 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 4333-56-6 ]

SDS Specification

Alternatived Products of [ 4333-56-6 ]

Product Details of [ 4333-56-6 ]

CAS No. :	4333-56-6	MDL No. :	MFCD00001271
Formula :	C₃H₅Br	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	LKXYJYDRLBPHRS-UHFFFAOYSA-N
M.W :	120.98	Pubchem ID :	78037
Synonyms :

Calculated chemistry of [ 4333-56-6 ] Expand+

Physicochemical Properties

Num. heavy atoms :	4
Num. arom. heavy atoms :	0
Fraction Csp3 :	1.0
Num. rotatable bonds :	0
Num. H-bond acceptors :	0.0
Num. H-bond donors :	0.0
Molar Refractivity :	22.29
TPSA :	0.0 ?2

Pharmacokinetics

GI absorption :	Low
BBB permeant :	No
P-gp substrate :	No
CYP1A2 inhibitor :	No
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-5.94 cm/s

Lipophilicity

Log Po/w (iLOGP) :	1.74
Log Po/w (XLOGP3) :	1.54
Log Po/w (WLOGP) :	1.48
Log Po/w (MLOGP) :	1.63
Log Po/w (SILICOS-IT) :	1.98
Consensus Log Po/w :	1.67

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	3.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	-1.56
Solubility :	3.33 mg/ml ; 0.0275 mol/l
Class :	Very soluble
Log S (Ali) :	-1.15
Solubility :	8.58 mg/ml ; 0.0709 mol/l
Class :	Very soluble
Log S (SILICOS-IT) :	-1.28
Solubility :	6.31 mg/ml ; 0.0521 mol/l
Class :	Soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	1.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	2.57

Safety of [ 4333-56-6 ]

Signal Word:	Danger	Class:	3
Precautionary Statements:	P210-P261-P305+P351+P338	UN#:	1993
Hazard Statements:	H225-H315-H319-H335	Packing Group:	Ⅱ
GHS Pictogram:

Application In Synthesis of [ 4333-56-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 4333-56-6 ]
Downstream synthetic route of [ 4333-56-6 ]

[ 4333-56-6 ] Synthesis Path-Upstream 1~1

1
[ 2075-45-8 ]
[ 4333-56-6 ]
[ 1151802-23-1 ]

Yield	Reaction Conditions	Operation in experiment
68%	With caesium carbonate In N,N-dimethyl-formamide at 180℃; for 1.5 h; Microwave irradiation	Step 1 : 4-Bromo- 1 -cyc A mixture of 4-bromo-lH-pyrrazole (1.0 g, 6.8 mmol), bromo cyclopropane (1.3 g, 10.7 mmol), cesium carbonate (3.5 g. 10.7 mmol), and DMF (6 mL) in a 30 mL microwave vial is heated to 180 °C under radiation for 1.5 hr. After cooled to room temperature, the reaction mixture is filtered. The filtrate is concentrated and the residue is purified on a silica gel flash chromatography with ethyl acetate/petroleum ether (1 :5) to get a brown liquid (0.87 g, 68percent yield). (MS: [M+l] 259)

Reference： [1] Patent: WO2014/32498, 2014, A1, . Location in patent: Page/Page column 14
[2] Patent: US2015/31673, 2015, A1, . Location in patent: Paragraph 0334

[ 4333-56-6 ] Synthesis Path-Downstream 1~10

1
[ 704-38-1 ]
[ 4333-56-6 ]
[ 109857-79-6 ]

Reference： [1]Journal of Medicinal Chemistry,1993,vol. 36,p. 1716 - 1725

2
[ 4333-56-6 ]
[ 100-52-7 ]
tri-n-butyllithium magnesate complex [ No CAS ]
[ 583-03-9 ]
[ 1007-03-0 ]

Reference： [1]Journal of Organic Chemistry,2001,vol. 66,p. 4333 - 4339

3
[ 4333-56-6 ]
[ 141483-15-0 ]
[ 1056942-32-5 ]

Yield	Reaction Conditions	Operation in experiment
	With caesium carbonate; sodium iodide; In N,N-dimethyl-formamide; at 150℃;	To a solution of 2-fluoro-5-trifluoromethyl phenol in DMF (2 mL) was added cyclopropyl bromide (2 eq.), Nal (1.0 mol %) and cesium carbonate (3 eq.). The reaction mixture was heated in a pressure tube at 150 C. overnight. The completion of the reaction was confirmed by LCMS. The reaction mixture was then diluted with ethyl acetate, washed with water and extracted with ethyl acetate (3×). The combined organic layer was dried over sodium sulfate, filtered, and concentrated to yield the crude product which was used in the next step without further purification.

Reference： [1]Patent: US2007/265332,2007,A1 .Location in patent: Page/Page column 18

4
[ 704-38-1 ]
concentrated ammonium chloride [ No CAS ]
[ 4333-56-6 ]
[ 109857-80-9 ]

Yield	Reaction Conditions	Operation in experiment
	With hydrogen bromide; magnesium; In tetrahydrofuran; water; acetic acid;	(a) To a suspension of 1.3 g of magnesium in 20 ml of anhydrous tetrahydrofuran, 8.0 g of cyclopropyl bromide in 15 ml of anhydrous tetrahydrofuran was added under nitrogen. The reaction mixture was kept under reflux for 1 h and then cooled to ambient temperature. To the reaction mixture 5.4 g of bis(thien-2-yl)ketone dissolved in 15 ml of anhydrous tetrahydrofuran was added dropwise. After refluxing for 30 min. the reaction mixture was chilled and 35 of a concentrated ammonium chloride solution was carefully added. To the resulting mixture 50 ml of water was added, and the suspension was extracted twice with 50 ml of ether. The ether extracts were washed with water, dried and evaporated leaving 7.6 g of an oil. The crude product was dissolved in 60 ml of acetic acid and a mixture of 30 ml of acetic acid and 15 ml of 48% hydrobromic acid was added at 5 C. The mixture was stirred for 30 min. and then poured into 300 ml of water. The resulting emulsion was extracted twice with 100 ml of ether. The ether extracts were washed with water, dried and evaporated leaving 8.5 g of an oil. From this oil, 5.2 g of 4,4-bis(thien-2-yl)but-3-enyl bromide having a boiling point (hereinafter b.p.) of 137 C. (0.05 mm Hg) was obtained by fractional distillation in vacuum.
	With hydrogen bromide; magnesium; In tetrahydrofuran; water; acetic acid;	a) To a suspension of 1.3 g of magnesium in 20 ml of anhydrous tetrahydrofuran, 8.0 g of cyclopropyl bromide in 15 ml of anhydrous tetrahydrofuran was added under nitrogen. The reaction mixture was kept under reflux for 1 hour and then cooled to ambient temperature. To the reaction mixture, 5.4 g of di(thien-2-yl)ketone dissolved in 15 ml of anhydrous tetrahydrofuran was added dropwise. After refluxing for 30 minutes, the reaction mixture was chilled and 35 ml of a concentrated ammonium chloride solution was carefully added. To the resulting mixture, 50 ml of water was added and the suspension was extracted twice with 50 ml of ether. The ether extracts were washed with water, dried and evaporated leaving 7.6 g of an oil. The crude product was dissolved in 60 ml of acetic acid and a mixture of 30 ml of acetic acid and 15 ml of 48% hydrobromic acid was added at 5C. The mixture was stirred for 30 minutes and then poured into 300 ml of water. The resulting emulsion was extracted twice with 100 ml of ether. The ether extracts were washed with water, dried and evaporated leaving 8.5 g of an oil. From this oil, 5.2 g of 4,4-di(thien-2-yl)but-3-enyl bromide having a boiling point (hereinafter b.p.) of 137C (0.05 mm Hg) was obtained by fractional distillation in vacuum.

Reference： [1]Patent: US5010090,1991,A
[2]Patent: EP236342,1991,B1

5
[ 4333-56-6 ]
[ 35344-95-7 ]
[ 1082066-00-9 ]

Yield	Reaction Conditions	Operation in experiment
8.82%	With potassium carbonate; In N,N-dimethyl-formamide; at 110℃; for 16h;Sealed tube;	To the stirred solution of lH-<strong>[35344-95-7]pyrazole-4-carbaldehyde</strong> 19-4 (200 mg, 2.08 mmol) in DMF (2 ml) in a sealed tube were added potassium carbonate (719.19 mg, 5.20 mmol, 314.06 uL) and bromocyclopropane 19-5 (251.80 mg, 2.08 mmol, 166.76 uL). The reaction mixture was heated at H0C for 16 hours and then cooled to room temperature, diluted with ethyl acetate, washed with water, brine, dried over sodium sulfate and concentrated under reduced pressure. The crude material was purified by column chromatography to afford l-cyclopropylpyrazole-4-carbafdehyde 19-6 (25 mg, 183.62 umol, 8.82% yield) as gum. NMR (400 MHz, DMSO-d6) d 9.75 (s, 1H), 8.53 (s, 1H), 7.95 (s, 1 1 1 ), 3.86-3.82 (m, 1 1 1 ), 1. 10-1.08 (m, 2) 1 ).. 1.03-0.98 (m, 21 1).
	With potassium carbonate; In N,N-dimethyl-formamide; at 130℃; for 18h;	Preparation 54: 1 -Cyclopropyl- 1 H-<strong>[35344-95-7]pyrazole-4-carbaldehyde</strong>Dissolve lH-<strong>[35344-95-7]pyrazole-4-carboxaldehyde</strong> in N,N-dimethylformamide (1.9 mL). Add potassium carbonate (0.539 g, 3.90 mmol) and cyclopropylbromide (0.346 g, 2.86 mmol). Heat in a pressure tube to 130 0C for 18 hr. Cool to ambient temperature and add DCM and water. Separate layers and extract water layer 3 times with DCM. Wash combined DCM layers with brine, dry (magnesium sulfate), filter, and concentrated to give the free base of the title preparation. GC-MS: m/z = 136 [M+].

Reference： [1]Patent: WO2019/191112,2019,A1 .Location in patent: Page/Page column 318; 319
[2]Patent: WO2008/141020,2008,A1 .Location in patent: Page/Page column 61

6
CBr₄ [ No CAS ]
[ 4333-56-6 ]
[ 1200828-74-5 ]

Yield	Reaction Conditions	Operation in experiment
62%	With triphenylphosphine;iodine; In tetrahydrofuran; hexane; ethyl alpha-hydroxycyclopropaneacetate; 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran;	Example 2 Synthesis of ethyl alpha-bromocyclopropaneacetate (46, R=c-Pr) A flame dried two-neck round bottom flask fitted with a reflux condenser and N2 outlet was charged with anhydrous THF, freshly activated Mg (120 mg, 4.95 mmol) and a catalytic amount of iodine. A small portion of cyclopropyl bromide dissolved in THF was added. After initiation of reflux, the reaction mixture was cooled to -20 C. and the remaining cyclopropyl bromide (500 mg, 4.13 mmol) was gradually added. After 30 min a freshly distilled solution of glyoxylate 45 (549 mg, 5.37 mmol) in THF was added over a 10 min period and the resulting solution was stirred at -20 C. for 2 h before being quenched with a small amount of water. After 10 min the reaction mixture was further diluted with water (50 mL) and extracted with ethyl acetate (3*50 mL). The organic extracts were combined, dried over anhydrous MgSO4, filtered, concentrated in vacuo and purified by column chromatography eluting with ethyl acetate/n-hexane (a gradient of 10-20%) to furnish ethyl alpha-hydroxycyclopropaneacetate (422 mg, 71%) as a viscous oil. The oil (350 mg, 2.43 mmol) was dissolved in anhydrous DCM and cooled to 0 C. Then Ph3P (2.04 gm, 7.78 mmol) was added followed by CBr4 (1.20 gm, 3.64 mmol). The reaction mixture was stirred at 0 C. for 2 h and then concentrated in vacuo. The Ph3PO was precipitated by addition of n-hexane and removed by filtration. The crude reaction mixture was purified by flash column chromatography to furnish ethyl alpha-bromocyclopropaneacetate (46, R=c-Pr): (311 mg, 62% yield).

Reference： [1]Patent: US2012/101096,2012,A1

7
[ 4333-56-6 ]
[ 189680-06-6 ]
[ 1594130-69-4 ]

Yield	Reaction Conditions	Operation in experiment
	With potassium carbonate; In N,N-dimethyl-formamide; at 120℃; for 16.0h;	To a stirred mixture of 2.50 g (13 mmol) <strong>[189680-06-6]2-bromo-5-hydroxy-benzonitrile</strong> in 100 mL DMF are added 5.23 g (38 mmol) K2CO3 and 3.05 g (25 mmol) cyclopropylbromide. The reaction mixture is stirred for 16 h at 120 C. Afterwards the reaction is quenched by the addition of ice water and extracted with EtOAc. The org. layers are combined, washed with sat. aq. NaCl solution, dried over Na2SO4, filtered and the solvent is removed in vacuo. The crude product is purified by column chromatography (silica gel, PE/EtOAc). [0425] C10H8BrNO (M=238.1 g/mol) [0426] Rf (TLC): 0.8 (silica gel, PE/EtOAc 9/1))
	With potassium carbonate; In N,N-dimethyl-formamide; at 120℃; for 16.0h;	Example XVIII 2-Bronno-5-cvclopropoxy-benzonitrile To a stirred mixture of 2.50 g (13 mmol) <strong>[189680-06-6]2-bromo-5-hydroxy-benzonitrile</strong> in 100 mL DMF are added 5.23 g (38 mmol) K2CO3 and 3.05 g (25 mmol) cydopropylbromide. The reaction mixture is stirred for 16 h at 120 C. Afterwards the reaction is quenched by the addition of ice water and extracted with EtOAc. The org. layers are combined, washed with sat. aq. NaCI solution, dried over Na2SO4 , filtered and the solvent is removed in vacuo. The crude product is purified by column chromatography (silica gel, PE/EtOAc). CioH8BrNO (M= 238.1 g/mol) Rf (TLC): 0.8 (silica gel, PE/EtOAc 9/1 ))

Reference： [1]Patent: US2014/100211,2014,A1 .Location in patent: Paragraph 0424-0426
[2]Patent: WO2014/56771,2014,A1 .Location in patent: Page/Page column 85

8
[ 4333-56-6 ]
[ 100-52-7 ]
[ 1007-03-0 ]

Yield	Reaction Conditions	Operation in experiment
20%		A two-necked, round-bottom flask containing 230 mg (8.3 mmol) ofmagnesium was equipped with a rubber septum, reflux condenser,and a magnetic stirring bar. Anhydrous Et2O (4 mL) was introducedto cover the magnesium, and dibromoethane (0.025 mL) was addedby syringe. After stirred for 5 minutes, Et2O (6 mL) was added. As the contents of theflask were stirred, bromocyclopropane (1.0 g, 8.3 mmol) was added dropwise bysyringe. The mixture was stirred for an additional one hour at room temperature. Tothe resulting solution was added benzaldehyde (0.68 mL, 6.64 mmol) dropwise bysyringe. The reaction was quenched with H2O and HCl (ca 1 N). The aqueous layerwas extracted with diethyl ether, and the combined organic layers were dried overMgSO4, filtrated, and concentrated in vacuo. The crude product was applied to flashcolumn chromatography eluted with hexane/AcOEt = 10/1 to give the product (463mg, 20% yield). The NMR data are in agreement with those previously reported inliterature10. 1H NMR (CDCl3, 500 MHz): 0.35-0.40 (m, 1H), 0.45-0.50 (m, 1H),0.53-0.58 (m, 1H), 0.62-0.67 (m, 1H), 1.19-1.27 (m, 1H), 1.94 (br, 1H), 4.01 (d, J =8.0 Hz, 1H), 7.26-7.43 (m, 5H). 13C NMR (CDCl3, 125 MHz): 143.7, 128.4, 127.5,126.0, 78.6, 19.2, 3.6, 2.8.

Reference： [1]Synlett,2016,vol. 27,p. 789 - 793

9
[ 4333-56-6 ]
[ 855836-62-3 ]
2-bromo-1-chloro-3-cyclopropoxybenzene [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
75%	With potassium carbonate; In N,N-dimethyl-formamide; at 150℃; for 0.5h;Inert atmosphere; Microwave irradiation;	A mixture of 2-brorno-3-choropheno(200 mg, 0.96 mmo), bromocyciopropane (96 uL, 1.2 mmo), and potassium carbonate(138 mg, 0.96 mmofl in DMF (1.0 mL) was heated at 150 C in a microwave oven for 30minutes. The reaction mixture was cooed to rt, diuted with water, and extracted with EtOAc (x2). The organc extracts were dried (Na2SO4), ifitered and concentrated in vacuoto obtain the desred product as an o (180 rng, 75%). ?H NMR (400 MHz, DMSO-d6): 57.46 7.31 (m, 2H), 7.27 - 7.18 (dd, J = 7,7, 1.7 Hz, I H), 4.04 3.91 (m, I H), 0.91 0.79(m, 2H), 0.78 - 0.63 (m, 2H).

Reference： [1]Patent: WO2016/176449,2016,A1 .Location in patent: Page/Page column 137; 138

10
[ 4333-56-6 ]
[ 41602-56-6 ]
2-cyclopropoxy-4-(dimethylamino)benzaldehyde [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
42%	With potassium carbonate; potassium iodide; In 1-methyl-pyrrolidin-2-one; at 200℃; for 3h;Inert atmosphere; Sealed tube;	In a flame dried reaction tube equipped with a stir bar was added 4-(dimethylamino)-2-hydroxy-benzaldehyde (165 mg, 1.00 mmol), cyclopropyl bromide (157 mg, 1.30 mmol, 104 uL), potassium carbonate (207 mg, 1.50 mmol), potassium iodide (8.30 mg, 0.0500 mmol) and NMP (1.00 mL). The vial was flushed with Ar, sealed with a teflon septa crimp cap, and stirred at 200 C. for 3 h. The reaction was cooled to RT, and vacuum filtered to remove undissolved solids, rinsing with DCM. The organics were concentrated in vacuo, and the residue was purified by flash chromatography on a 12 g SiO2 cartridge (gradient from 0 to 20% EtOAc in hexanes) to afford 2-(cyclopropoxy)-4-(dimethylamino)benzaldehyde (87.0 mg, 0.420 mmol, 42% yield). 1H NMR: (400 MHz, Chloroform-d) delta 10.09 (s, 1H), 7.72 (d, J=8.8 Hz, 1H), 6.46 (d, J=2.3 Hz, 1H), 6.32 (dd, J=8.8, 2.3 Hz, 1H), 3.81 (tt, J=6.0, 3.3 Hz, 1H), 3.09 (s, 6H), 0.90-0.79 (overlap, 4H). ESI-MS: [M+H]+ calculated for C12H15NO2 206.110; found 207.187. UV: lambda (max) 353.2 nm.

Reference： [1]Patent: US2020/39996,2020,A1 .Location in patent: Paragraph 0407; 0438-0440

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Technical Information

? Alkyl Halide Occurrence ? General Reactivity ? Grignard Reaction ? Halogenation ? Heat of Combustion ? Hiyama Cross-Coupling Reaction ? Kinetics of Alkyl Halides ? Kumada Cross-Coupling Reaction ? Reactions of Alkyl Halides with Reducing Metals ? Reactions of Amines ? Reactions of Dihalides ? Stille Coupling ? Substitution and Elimination Reactions of Alkyl Halides ? Suzuki Coupling

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P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

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[ CAS No. 4333-56-6 ] {[proInfo.proName]}

Quality Control of [ 4333-56-6 ]

Related Doc. of [ 4333-56-6 ]

Product Details of [ 4333-56-6 ]

Calculated chemistry of [ 4333-56-6 ] Expand+

Physicochemical Properties

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Lipophilicity

Druglikeness

Water Solubility

Medicinal Chemistry

Safety of [ 4333-56-6 ]

Application In Synthesis of [ 4333-56-6 ]

[ 4333-56-6 ] Synthesis Path-Upstream 1~1

[ 4333-56-6 ] Synthesis Path-Downstream 1~10

Technical Information

Related Functional Groups of [ 4333-56-6 ]

Aliphatic Cyclic Hydrocarbons

Bromides

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Response

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[ 4333-56-6 ]