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CAS No. : | 3886-08-6 | MDL No. : | MFCD00038274 |
Formula : | C17H23NO6 | Boiling Point : | - |
Linear Structure Formula : | C6H5CH2OCONHCH(CH2CH2COOC(CH3)3)COOH | InChI Key : | GLMODRZPPBZPPB-ZDUSSCGKSA-N |
M.W : | 337.37 | Pubchem ID : | 107472 |
Synonyms : |
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Chemical Name : | (S)-2-(((Benzyloxy)carbonyl)amino)-5-(tert-butoxy)-5-oxopentanoic acid |
Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P261-P264-P271-P272-P280-P302+P352-P304+P340+P312-P305+P351+P338-P333+P313-P337+P313-P362+P364-P403+P233-P405-P501 | UN#: | N/A |
Hazard Statements: | H315-H317-H319-H335 | Packing Group: | N/A |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Preparative Example C Synthesis of N-(Toluene-4-sulfonyl)-L-prolyl-D-glutamic acid N-Benzyloxycarbonyl-D-5-(1,1-dimethylethyl)-glutamic acid was converted to the methyl ester using the procedure described in Method 2. D-5-(1,1-dimethylethyl)-glutamic acid methyl ester was prepared from the product of the previous step utilizing the procedure described in Method 4. N-(Toluene-4-sulfonyl)-L-proline hydrate was coupled to the resulting D-5-(1,1-dimethylethyl)-glutamic acid methyl ester utilizing the procedure described in Method 3. The methyl ester was hydrolyzed using the procedure described in Method 6. The product was isolated as a white solid, mp=50 C. The title compound was then prepared using the procedure described in Method 11. The product as isolated as a white solid, mp=60 C. NMR data was as follows: 1H NMR (DMSO-d6, 300 MHz):δ=8.12 (d, 1 H, J=4.0 Hz); 7.73 (m, 2 H); 7.43, (m, 2 H); 4.25 (m, 1 H); 4.05 (m, 1 H); 3.43 (m, 1 H); 3.15 (m, 1 H); 2.40 (s, 3 H), 2.45 (m, 2 H); 2.02 (m, 2 H); 1.90-1.40 (bm, 4 H). |