[ CAS No. 369-34-6 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}

Cat. No.: {[proInfo.prAm]}

2D 3D

Structure of 369-34-6 * Storage: {[proInfo.prStorage]}

Purity	Size	Price	VIP Price	USA Stock *0-1 Day	Global Stock *5-7 Days	Quantity
{[ item.p_purity ]}	{[ item.pr_size ]}	Inquiry	{[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,1,item.pr_is_large_size_no_price) ]}	{[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price) ]}	Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price) ]} {[ getRatePrice(item.pr_usd,1,item.mem_rate,item.pr_is_large_size_no_price) ]}	{[ item.pr_usastock ]}		{[ item.pr_chinastock ]}	{[ item.pr_remark ]}	Login		Inquiry

Please Login or Create an Account to: See VIP prices and availability

Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Search after Editing

* Storage: {[proInfo.prStorage]}

* Shipping: {[proInfo.prShipping]}

For Research Only 120K+ Compounds Competitive Price 1-2 Day Shipping

Quality Control of [ 369-34-6 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 369-34-6 ]

SDS Specification

Alternatived Products of [ 369-34-6 ]

Product Details of [ 369-34-6 ]

CAS No. :	369-34-6	MDL No. :	MFCD00007198
Formula :	C₆H₃F₂NO₂	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	RUBQQRMAWLSCCJ-UHFFFAOYSA-N
M.W :	159.09	Pubchem ID :	123053
Synonyms :

Calculated chemistry of [ 369-34-6 ] Expand+

Physicochemical Properties

Num. heavy atoms :	11
Num. arom. heavy atoms :	6
Fraction Csp3 :	0.0
Num. rotatable bonds :	1
Num. H-bond acceptors :	4.0
Num. H-bond donors :	0.0
Molar Refractivity :	35.18
TPSA :	45.82 ?2

Pharmacokinetics

GI absorption :	High
BBB permeant :	Yes
P-gp substrate :	No
CYP1A2 inhibitor :	No
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-5.67 cm/s

Lipophilicity

Log Po/w (iLOGP) :	1.36
Log Po/w (XLOGP3) :	2.25
Log Po/w (WLOGP) :	2.71
Log Po/w (MLOGP) :	1.73
Log Po/w (SILICOS-IT) :	0.55
Consensus Log Po/w :	1.72

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	1.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	-2.58
Solubility :	0.417 mg/ml ; 0.00262 mol/l
Class :	Soluble
Log S (Ali) :	-2.85
Solubility :	0.226 mg/ml ; 0.00142 mol/l
Class :	Soluble
Log S (SILICOS-IT) :	-2.33
Solubility :	0.753 mg/ml ; 0.00473 mol/l
Class :	Soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	2.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	1.82

Safety of [ 369-34-6 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P210-P261-P264-P271-P280-P302+P352-P304+P340+P312-P305+P351+P338-P332+P313-P337+P313-P370+P378-P403+P233-P403+P235-P405-P501	UN#:	N/A
Hazard Statements:	H315-H319-H335-H227	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 369-34-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 369-34-6 ]
Downstream synthetic route of [ 369-34-6 ]

[ 369-34-6 ] Synthesis Path-Upstream 1~1

1
[ 369-34-6 ]
[ 1403767-19-0 ]
[ 1206800-24-9 ]

Reference： [1] Organic Process Research and Development, 2014, vol. 18, # 4, p. 501 - 510
[2] Organic Process Research and Development, 2018, vol. 22, # 3, p. 409 - 419

[ 369-34-6 ] Synthesis Path-Downstream 1~10

1
[ 369-34-6 ]
[ 134575-12-5 ]
[ 392660-08-1 ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2005,vol. 15,p. 4261 - 4267

2
[ 67-56-1 ]
[ 369-34-6 ]
[ 455-93-6 ]

Yield	Reaction Conditions	Operation in experiment
91%	With sodium; at 10 - 20℃; for 2 - 3h;	Step 4: Preparation of 3-fluoro-4-methoxyaniline (8) Metallic sodium (1.45 grams, 63 mmol) was added slowly and portion wise to pre cooled (10 C.) methanol (100 mL) with stirring under nitrogen atmosphere. The mixture was stirred at room temperature until all the sodium metal gets dissolved. To this was added 3,4-difluoro nitrobenzene (6) (10 grams, 63 mmol) at room temperature and stirring continued at the same temperature for 2-3 hours. The mixture was then concentrated under vacuum and poured into ice-water (100 mL). The pH of the mixture was adjusted to ~7 by adding 2N HCl with stirring. The solid separated was filtered off, washed with water and dried under vacuum to afford the product 2-fluoro-4-nitroanisol (7) (9.75 grams). Yield: 91%; Melting point: 102-104 C.
64%	With potassium hydroxide; In dimethyl sulfoxide; at 20℃; for 16h;	General procedure: A mixture of 2-fluorobenzamide (1a, 69.5 mg, 0.5 mmol), MeOH (ca. 32.0 mg, 1.0 mmol), KOH (56.0 mg, 1.0 mmol) and DMSO (2.0 mL) in a 25 mL screw-capped thick-walled Pyrex tube was stirred at room temperature for 16 h, and then water (10 mL) was added to the reaction mixture with stirring, and the mixture was extracted with ethyl acetate three times (3 * 10 mL). The combined organic phases were dried over Na2SO4 overnight. The filtered solution was concentrated under reduced pressure, and the crude residue was purified by column chromatography on silica gel with the use of petroleum ether/ethyl acetate/trimethylamine (gradient mixture ratio from 6:1:0.05 to 2:1:0.05 in volume) to afford 2aa as a white solid in 80% yield (60.7 mg).
57%	With sodium hydroxide; In dimethyl sulfoxide; at 20℃; for 12h;	3,4-difluoronitrobenzene (31.88, 0.2111001), high purity NaOH (168,0.4111001), methanol (88,0.25mo 1), DMSO (200 mL) was added to the reactor and the reaction was stirred at 20 C for 12 hours. After completion of the reaction, 800 mL of ethyl acetate was added to the system and diluted 5 times with 200 mL of saturated brine. The organic phase was separated and dried over anhydrous sodium sulfateAfter which it was filtered, evaporated to dryness, and then it was loaded onto a silica gel column to separate petroleum ether: ethyl acetate = 4: 1 (volume) Was eluted as an eluent until the product appeared, the solution containing the product was collected and evaporated to dryness. After drying with a vacuum chestnut, 3-fluoro-4-methoxy nitrobenzene pure product, the yield of 57%.

Reference： [1]Patent: US2006/128729,2006,A1 .Location in patent: Page/Page column 77
[2]Tetrahedron,2018,vol. 74,p. 303 - 307
[3]Patent: CN106565522,2017,A .Location in patent: Paragraph 0037; 0038
[4]Russian Chemical Bulletin,2006,vol. 55,p. 1243 - 1247

3
[ 369-34-6 ]
[ 7126-38-7 ]
[ 252336-89-3 ]

Yield	Reaction Conditions	Operation in experiment
	In N,N-dimethyl-formamide;	3-Fluoro-4-(3-cyano-1-pyrrolyl)nitrobenzene <strong>[7126-38-7]3-Cyanopyrrole</strong> (3.6 g, 39.1 mmol, CE Loader et al, Can. J. Chem., 1981, 59, 2673) and 3,4-difluoronitrobenzene (6.5 g, 40.9 mmol) were dissolved in DMF (50 ml) and cooled in an ice-bath. The mixture was stirred and sodium hydride (60percent in oil, 1.6 g, 40 mmol) added over 20 minutes. After allowing the mixture to come to ambient temperature, it was heated to 65° for 1 hour. Solvent was evaporated, the residue triturated with water, and filtered. The crude solide was purified by flash chromatography on silica, eluding with dichloromethane. Relevant fractions were combined to give the title product (3.75 g), mp 117-119°. MS (ESP): 230 (MH-) for C11H6FN3O2 NMR (CDCl3) delta: 6.68 (s, 1H); 7.09 (m, 1H); 7.61 (overlapping m, 2H); 8.20 (overlapping m, 2H).

Reference： [1]Patent: US2003/144263,2003,A1

4
[ 369-34-6 ]
[ 7087-68-5 ]
[ 59702-07-7 ]
3-fluoro-4-(4-methyl-3-oxopiperazin-1-yl)nitrobenzene [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	In 2-Methylpentane; ethyl acetate; acetonitrile;	N,N-Diisopropylethylamine (11.5 ml) and 1-methyl-2-oxopiperazine (4.12 g) were added to a solution of 3,4-difluoronitrobenzene (1.82 ml) in acetonitrile (100 ml), and the mixture heated to reflux for 16 hours. Solvent was evaporated, and the residue chromatographed on silica, using as eluant a gradient increasing in polarity from 0 to 100percent ethyl acetate in iso-hexane. Relevant fractions were combined and evaporated to give 3-fluoro-4-(4-methyl-3-oxopiperazin-1-yl)nitrobenzene (3.37 g). MS (CI): 254 (MH+). NMR (DMSO-D6) delta: 3.06 (s,3H); 3.53 (t,2H); 3.67 (t,2H); 3.97 (s,2H): 6.90 (t,1H); 7.95 (dd,1H); 8.02 (m,1H).

Reference： [1]Patent: US6069145,2000,A

5
[ 369-34-6 ]
[ 5823-51-8 ]
[ 1092980-94-3 ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2008,vol. 18,p. 5815 - 5818

6
[ 22300-52-3 ]
[ 369-34-6 ]
[ 1192847-34-9 ]

Reference： [1]Organic Letters,2009,vol. 11,p. 5026 - 5028

7
[ 4138-26-5 ]
[ 369-34-6 ]
[ 1000051-47-7 ]

Yield	Reaction Conditions	Operation in experiment
76%	With triethylamine; In methanol; at 50 - 60℃; for 24h;	3-11-1:Preparation of [3-fluoro-4-(3-carbamoylpiperidino)]nitrobenzeneTo 50 ml of methanol were sequentially added 5 g (31.4 mmol) of 3,4-difluoronitrobenzene, 5.26 ml (37.7 mmol) of triethylamine and 4.4 g (34.6 mmol) of <strong>[4138-26-5]nipecotamide</strong>, followed by reaction at a temperature of 50 to 60° for 24 hours.After the reaction was complete, the reaction liquid was cooled to room temperature.The resulting solid was filtered, washed with about 50 ml of methanol and then dried under vacuum at about 40° to afford 5.7 g (yield: 76percent) of the desired compound.Mass (M+): 268.11H-NMR (DMSO-d6): 1.56(t, 2H), 1.74(m, 1H), 1.89(m, 1H), 2.48(m, 1H), 2.88(m, 1H), 2.96(m, 1H), 3.64(m, 2H), 6.91(s, 1H), 7.15(m, 1H), 7.38(s, 1H), 7.95(m, 2H).
76%	With triethylamine; In methanol; at 50 - 60℃; for 24h;	Example 3-11-1 Preparation of [3-fluoro-4-(3-carbamoylpiperidino)]nitrobenzene To 50ml of methanol were sequentially added 5g (31.4mmol) of 3,4-difluoronitrobenzene, 5.26ml (37.7mmol) of triethylamine and 4.4g (34.6mmol) of <strong>[4138-26-5]nipecotamide</strong>, followed by reaction at a temperature of 50 to 60°C for 24 hours. After the reaction was complete, the reaction liquid was cooled to room temperature. The resulting solid was filtered, washed with about 50ml of methanol and then dried under vacuum at about 40°C to afford 5.7g (yield: 76percent) of the desired compound. Mass (M+): 268.1 1H-NMR (DMSO-d6): 1.56(t, 2H), 1.74(m, 1H), 1.89(m, 1H), 2.48(m, 1H), 2.88(m, 1H), 2.96(m, 1H), 3.64(m, 2H), 6.91(s, 1H), 7.15(m, 1H), 7.38(s, 1H), 7.95(m, 2H).

Reference： [1]Patent: US2011/306606,2011,A1 .Location in patent: Page/Page column 18
[2]Patent: EP2394993,2011,A2 .Location in patent: Page/Page column 28

8
[ 130596-62-2 ]
[ 369-34-6 ]
[ 1430321-42-8 ]

Yield	Reaction Conditions	Operation in experiment
70%		To a solution of 4 (500 mg, 3.85 mmol) in ethylacetate, triethylamine (973 mg, 9.63 mmol) is added and stirred at 25 C for 10 min. The reaction mixture is cooled to 0 C and 3, 4- difluoronitrobenzene (612 mg, 3.85 mmol) is added dropwise and allowed to stir at 25 C for 6 h. Water is then added and the organic layer is separated. The aqueous layer is extracted with EtOAc and the solvent is removed. The product is purified by column chromatography using hexanes-EtOAc mixtures to obtain the product as a crystalline yellow solid 9 (721 mg) in 70% isolated yield. 1H NMR (50 MHz, CDC13): delta 7.93-7.84 (m, 2 H), 6.86 (t, J = 4 Hz, 1 H), 3.70-3.67 (m, 4 H), 0.91- 0.85 (m, 4 H), 0.12 (s, 6 H). 13C NMR (100 MHz, CDC13): delta 151.12 (d, J = 246.71 Hz), 144.43 (d, J = 7.13 Hz), 137.84 (d, J = 8.59 Hz), 121.45, 1 15.90 (d, J = 4.61 Hz), 113.18 (7 = 27.78 Hz), 49.44, 13.79, -2.85.
70%		To a solution of 4 (500 mg, 3.85 mmol) in ethylacetate, triethylamine (973 mg, 9.63 mmol) is added and stirred at 25 C. for 10 min. The reaction mixture is cooled to 0 C. and 3,4-difluoronitrobenzene (612 mg, 3.85 mmol) is added dropwise and allowed to stir at 25 C. for 6 h. Water is then added and the organic layer is separated. The aqueous layer is extracted with EtOAc and the solvent is removed. The product is purified by column chromatography using hexanes-EtOAc mixtures to obtain the product as a crystalline yellow solid 9 (721 mg) in 70% isolated yield. 1H NMR (50 MHz, CDCl3): delta 7.93-7.84 (m, 2H), 6.86 (t, J=4 Hz, 1H), 3.70-3.67 (m, 4H), 0.91-0.85 (m, 4H), 0.12 (s, 6H). 13C NMR (100 MHz, CDCl3): delta 151.12 (d, J=246.71 Hz), 144.43 (d, J=7.13 Hz), 137.84 (d, J=8.59 Hz), 121.45, 115.90 (d, J=4.61 Hz), 113.18 (J=27.78 Hz), 49.44, 13.79, -2.85.
28.1 g		4,4-Dimethyl azasilinane hydrochloride (19.3 g, 105.8 mmol) and triethylamine (48.2 g, 349.1 mmol) were dispersed in N,N-dimethylformamide (200 mL). The resulting mixture was stirred at room temperature for 10 min, and then transferred to an ice water bath and stirred. 3,4-Difluoronitrobenzene (16.8 g, 105.8 mmol) was added dropwise. After the completion of the dropwise addition, the resulting mixture was stirred for 30 min in an ice water bath, and then stirred at room temperature overnight. The reaction mixture was poured into 1 L of water, stirred for 10 min, suction-filtered, and washed with a large amount of water. The resulting solid was collected and dried to give 1-(2-fluoro-4-nitrophenyl)-4,4-dimethyl-1,4-azasilinane (28.1 g). 1H NMR (300 MHz, DMSO-d6): delta7.91-7.95 (m, 2H), 7.10-7.14 (m, 1H), 3.71-3.73 (m, 4H), 0.85-0.88 (m, 4H), 0.11 (s, 6H).

Reference： [1]Patent: WO2013/54275,2013,A1 .Location in patent: Page/Page column 19; 22
[2]Patent: US2014/296133,2014,A1 .Location in patent: Paragraph 0077; 0094
[3]ACS Medicinal Chemistry Letters,2015,vol. 6,p. 1105 - 1110
[4]Patent: US2020/17532,2020,A1 .Location in patent: Paragraph 0139; 0145-0147

9
[ 369-34-6 ]
[ 168268-00-6 ]

Reference： [1]Bioorganic and Medicinal Chemistry,2016,vol. 24,p. 3353 - 3358
[2]Bioorganic and Medicinal Chemistry,2017,vol. 25,p. 6674 - 6679
[3]Patent: CN108069919,2018,A
[4]European Journal of Medicinal Chemistry,2018,vol. 158,p. 814 - 831

10
[ 1825-61-2 ]
[ 369-34-6 ]
[ 455-93-6 ]

Reference： [1]Inorganic Chemistry,2016,vol. 55,p. 2274 - 2283

Recommend Products

Same Skeleton Products

Related Products

Isomers

Technical Information

? Alkyl Halide Occurrence ? Benzylic Oxidation ? Birch Reduction ? Blanc Chloromethylation ? Friedel-Crafts Reaction ? Hydrogenolysis of Benzyl Ether ? Preparation of Alkylbenzene ? Reactions of Benzene and Substituted Benzenes ? Vilsmeier-Haack Reaction

Historical Records

Pharmaceutical Intermediates of
[ 369-34-6 ]

Linezolid Related Intermediates

[ 496031-57-3 ]

(R)-5-(Chloromethyl)-3-(3-fluoro-4-morpholinophenyl)oxazolidin-2-one

[ 174649-09-3 ]

(R)-(3-(3-Fluoro-4-morpholinophenyl)-2-oxooxazolidin-5-yl)methyl methanesulfonate

[ 168828-90-8 ]

(S)-5-(Aminomethyl)-3-(3-fluoro-4-morpholinophenyl)oxazolidin-2-one

[ 168828-82-8 ]

(5R)-3-(3-Fluoro-4-(4-morpholinyl)phenyl)-5-hydroxymethyl-2-oxazolidione

[ 93246-53-8 ]

3-Fluoro-4-morpholinoaniline

Related Functional Groups of
[ 369-34-6 ]

Fluorinated Building Blocks

[ 402-67-5 ]

1-Fluoro-3-nitrobenzene

Similarity: 0.96

[ 78056-39-0 ]

3,4-Difluoro-6-nitroaniline

Similarity: 0.92

[ 66684-58-0 ]

1,2,3-Trifluoro-5-nitrobenzene

Similarity: 0.92

[ 2369-12-2 ]

3-Fluoro-5-nitroaniline

Similarity: 0.92

[ 211693-73-1 ]

2,3-Difluoro-6-nitroaniline

Similarity: 0.89

Aryls

[ 402-67-5 ]

1-Fluoro-3-nitrobenzene

Similarity: 0.96

[ 78056-39-0 ]

3,4-Difluoro-6-nitroaniline

Similarity: 0.92

[ 66684-58-0 ]

1,2,3-Trifluoro-5-nitrobenzene

Similarity: 0.92

[ 2369-12-2 ]

3-Fluoro-5-nitroaniline

Similarity: 0.92

[ 211693-73-1 ]

2,3-Difluoro-6-nitroaniline

Similarity: 0.89

Nitroes

[ 402-67-5 ]

1-Fluoro-3-nitrobenzene

Similarity: 0.96

[ 78056-39-0 ]

3,4-Difluoro-6-nitroaniline

Similarity: 0.92

[ 66684-58-0 ]

1,2,3-Trifluoro-5-nitrobenzene

Similarity: 0.92

[ 2369-12-2 ]

3-Fluoro-5-nitroaniline

Similarity: 0.92

[ 211693-73-1 ]

2,3-Difluoro-6-nitroaniline

Similarity: 0.89

Ghs Precautionary Statements

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

[ CAS No. 369-34-6 ] {[proInfo.proName]}

Quality Control of [ 369-34-6 ]

Related Doc. of [ 369-34-6 ]

Product Details of [ 369-34-6 ]

Calculated chemistry of [ 369-34-6 ] Expand+

Physicochemical Properties

Pharmacokinetics

Lipophilicity

Druglikeness

Water Solubility

Medicinal Chemistry

Safety of [ 369-34-6 ]

Application In Synthesis of [ 369-34-6 ]

[ 369-34-6 ] Synthesis Path-Upstream 1~1

[ 369-34-6 ] Synthesis Path-Downstream 1~10

Technical Information

Pharmaceutical Intermediates of [ 369-34-6 ]

Linezolid Related Intermediates

Related Functional Groups of [ 369-34-6 ]

Fluorinated Building Blocks

Aryls

Nitroes

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Pharmaceutical Intermediates of
[ 369-34-6 ]

Related Functional Groups of
[ 369-34-6 ]