天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

Home Cart 0 Sign in  

[ CAS No. 367-22-6 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
HazMat Fee +

There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Chemical Structure| 367-22-6
Chemical Structure| 367-22-6
Structure of 367-22-6 * Storage: {[proInfo.prStorage]}

Please Login or Create an Account to: See VIP prices and availability

Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Search after Editing

* Storage: {[proInfo.prStorage]}

* Shipping: {[proInfo.prShipping]}

Quality Control of [ 367-22-6 ]

Related Doc. of [ 367-22-6 ]

Alternatived Products of [ 367-22-6 ]
Product Citations

Product Details of [ 367-22-6 ]

CAS No. :367-22-6 MDL No. :MFCD01090987
Formula : C6H5ClFN Boiling Point : -
Linear Structure Formula :- InChI Key :ACMJJQYSPUPMPN-UHFFFAOYSA-N
M.W : 145.56 Pubchem ID :2736511
Synonyms :

Calculated chemistry of [ 367-22-6 ]      Expand+

Physicochemical Properties

Num. heavy atoms : 9
Num. arom. heavy atoms : 6
Fraction Csp3 : 0.0
Num. rotatable bonds : 0
Num. H-bond acceptors : 1.0
Num. H-bond donors : 1.0
Molar Refractivity : 35.81
TPSA : 26.02 ?2

Pharmacokinetics

GI absorption : High
BBB permeant : Yes
P-gp substrate : No
CYP1A2 inhibitor : No
CYP2C19 inhibitor : No
CYP2C9 inhibitor : No
CYP2D6 inhibitor : No
CYP3A4 inhibitor : No
Log Kp (skin permeation) : -5.73 cm/s

Lipophilicity

Log Po/w (iLOGP) : 1.54
Log Po/w (XLOGP3) : 2.06
Log Po/w (WLOGP) : 2.49
Log Po/w (MLOGP) : 2.51
Log Po/w (SILICOS-IT) : 2.21
Consensus Log Po/w : 2.16

Druglikeness

Lipinski : 0.0
Ghose : None
Veber : 0.0
Egan : 0.0
Muegge : 2.0
Bioavailability Score : 0.55

Water Solubility

Log S (ESOL) : -2.53
Solubility : 0.426 mg/ml ; 0.00293 mol/l
Class : Soluble
Log S (Ali) : -2.24
Solubility : 0.847 mg/ml ; 0.00582 mol/l
Class : Soluble
Log S (SILICOS-IT) : -2.91
Solubility : 0.179 mg/ml ; 0.00123 mol/l
Class : Soluble

Medicinal Chemistry

PAINS : 0.0 alert
Brenk : 1.0 alert
Leadlikeness : 1.0
Synthetic accessibility : 1.26

Safety of [ 367-22-6 ]

Signal Word:Danger Class:6.1
Precautionary Statements:P280-P301+P312+P330-P302+P352+P312-P304+P340+P311-P305+P351+P338 UN#:2811
Hazard Statements:H302-H311+H331-H315-H319-H335 Packing Group:Ⅲ
GHS Pictogram:

Application In Synthesis of [ 367-22-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 367-22-6 ]

[ 367-22-6 ] Synthesis Path-Downstream   1~7

  • 1
  • [ 367-22-6 ]
  • [ 348-59-4 ]
  • 2
  • [ 2268-05-5 ]
  • [ 367-22-6 ]
  • 4
  • [ 106-47-8 ]
  • [ 57946-56-2 ]
  • [ 367-22-6 ]
  • [ 2613-33-4 ]
  • [ 2613-30-1 ]
  • 5
  • [ 367-22-6 ]
  • [ 704-91-6 ]
  • N-(4-chloro-3-fluorophenyl)-1H-indazole-6-carboxamide [ No CAS ]
  • 6
  • [ 367-22-6 ]
  • [ 160893-07-2 ]
  • N-(4-chloro-3-fluorophenyl)-5-methoxyquinolin-2-amine [ No CAS ]
YieldReaction ConditionsOperation in experiment
In neat (no solvent); at 160℃; General procedure: A mixture of compound 3 (0.2 g, 1.03 mmol) and the appropriate aniline (1.03 mmol) were reacted neat at 160 C for 10-120 minutes. The reaction mixture was cooled, dissolved in DCM and concentrated under reduced pressure to afford the desired product, which was used directly in the next step without further purification.
  • 7
  • [ 149057-19-2 ]
  • [ 367-22-6 ]
  • C24H27ClFN3O5 [ No CAS ]
YieldReaction ConditionsOperation in experiment
216 mg With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20℃; for 18h;Inert atmosphere; To a solution of intermediate (586 mg, 1.61 mmol), 4-chloro-3- fluoroaniline (281 mg, 1.93 mmol), and HATU (673 mg, 1.77 mmol) in DMF (8.0 mL) at room temperature under N2 atmosphere was added diisopropylethylamine (0.84 mL, 4.8 mmol). The resulting mixture was stirred at room temperature for 18 h then concentrated in vacuo. The resulting residue was taken up in EtOAc and quenched with H2O. The layers were separated, and the aqueous phase was extracted with EtOAc (3x). The combined organic layers were washed with brine, dried over Na2SO4 and concentrated in vacuo. Flash chromatography (SiO2, 50:50 hexanes:EtOAc) afforded the product as a white solid (216 mg, 20% yield over 2 steps). 1H NMR (500 MHz, Chloroform-d) d 8.76 (s, 1H), 7.61 (d, J = 10.5 Hz, 1H), 7.30 (t, J = 8.4 Hz, 1H), 7.11- 7.04 (m, 1H), 4.59 (d, J = 4.2 Hz, 1H), 3.91 (s, 1H), 3.56 (d, J = 13.2 Hz, 1H), 3.05- 2.92 (m, 2H), 2.88 (dd, J = 13.4, 4.3 Hz, 1H), 2.78 (td, J = 12.4, 3.5 Hz, 1H), 1.52 (s, 9H); 13C NMR (126 MHz, CDCl3) d 174.33, 147.70, 143.90, 139.16, 129.72, 127.25, 125.47, 119.69, 117.66, 114.46, 52.08, 43.73, 38.55, 29.84; IR (ATR) vmax 3285, 2925, 2850, 1653, 1525, 1321, 1154, 983, 948, 826, 790, 506 cm-1; AMM 492.1708 (ESI) m/z [calc for C24H28ClFN3O5 (M+H)+ 492.1702].
Recommend Products
Same Skeleton Products

Technical Information

Historical Records

Related Functional Groups of
[ 367-22-6 ]

Fluorinated Building Blocks

Chemical Structure| 139512-70-2

[ 139512-70-2 ]

4-Chloro-5-fluorobenzene-1,2-diamine

Similarity: 0.94

Chemical Structure| 36556-60-2

[ 36556-60-2 ]

2-Chloro-3,5-difluoroaniline

Similarity: 0.92

Chemical Structure| 21397-08-0

[ 21397-08-0 ]

2-Chloro-3-fluoroaniline

Similarity: 0.91

Chemical Structure| 4863-91-6

[ 4863-91-6 ]

3-Chloro-5-fluoroaniline

Similarity: 0.91

Chemical Structure| 878285-12-2

[ 878285-12-2 ]

4-Chloro-2,3-difluoroaniline

Similarity: 0.90

Aryls

Chemical Structure| 139512-70-2

[ 139512-70-2 ]

4-Chloro-5-fluorobenzene-1,2-diamine

Similarity: 0.94

Chemical Structure| 36556-60-2

[ 36556-60-2 ]

2-Chloro-3,5-difluoroaniline

Similarity: 0.92

Chemical Structure| 21397-08-0

[ 21397-08-0 ]

2-Chloro-3-fluoroaniline

Similarity: 0.91

Chemical Structure| 4863-91-6

[ 4863-91-6 ]

3-Chloro-5-fluoroaniline

Similarity: 0.91

Chemical Structure| 878285-12-2

[ 878285-12-2 ]

4-Chloro-2,3-difluoroaniline

Similarity: 0.90

Chlorides

Chemical Structure| 139512-70-2

[ 139512-70-2 ]

4-Chloro-5-fluorobenzene-1,2-diamine

Similarity: 0.94

Chemical Structure| 36556-60-2

[ 36556-60-2 ]

2-Chloro-3,5-difluoroaniline

Similarity: 0.92

Chemical Structure| 21397-08-0

[ 21397-08-0 ]

2-Chloro-3-fluoroaniline

Similarity: 0.91

Chemical Structure| 4863-91-6

[ 4863-91-6 ]

3-Chloro-5-fluoroaniline

Similarity: 0.91

Chemical Structure| 878285-12-2

[ 878285-12-2 ]

4-Chloro-2,3-difluoroaniline

Similarity: 0.90

Amines

Chemical Structure| 139512-70-2

[ 139512-70-2 ]

4-Chloro-5-fluorobenzene-1,2-diamine

Similarity: 0.94

Chemical Structure| 36556-60-2

[ 36556-60-2 ]

2-Chloro-3,5-difluoroaniline

Similarity: 0.92

Chemical Structure| 21397-08-0

[ 21397-08-0 ]

2-Chloro-3-fluoroaniline

Similarity: 0.91

Chemical Structure| 4863-91-6

[ 4863-91-6 ]

3-Chloro-5-fluoroaniline

Similarity: 0.91

Chemical Structure| 878285-12-2

[ 878285-12-2 ]

4-Chloro-2,3-difluoroaniline

Similarity: 0.90

; ;