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With palladium diacetate; potassium carbonate; Trimethylacetic acid; at 120℃; for 1h;Inert atmosphere;
Under the atmosphere, a mixture of 8.32 g (29.2 mmol) of the intermediate 18 in 29.2 mL of pivalic acid was heated to 120 C. After adding 0.404 g (2.92 mmol) of potassium carbonate and 7.87 g (35.1 mmol) of palladium acetate (II), the mixture was stirred for one hour. (0260) After the reaction, the mixture was cooled to room temperature, diluted with ethyl acetate, and filtered to remove the impurities. The obtained filtrate washed with a sodium carbonate aqueous solution, dried over anhydrous magnesium sulfate, filtered, and then concentrated. The obtained residue was purified by silica gel column chromatography and recrystallization to obtain 5.15 g (yield: 62%) of solid, which was identified as the following intermediate 19 by FD-MS analysis.
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