天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

Home Cart 0 Sign in  

[ CAS No. 344-19-4 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
HazMat Fee +

There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Chemical Structure| 344-19-4
Chemical Structure| 344-19-4
Structure of 344-19-4 * Storage: {[proInfo.prStorage]}

Please Login or Create an Account to: See VIP prices and availability

Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Search after Editing

* Storage: {[proInfo.prStorage]}

* Shipping: {[proInfo.prShipping]}

Quality Control of [ 344-19-4 ]

Related Doc. of [ 344-19-4 ]

Alternatived Products of [ 344-19-4 ]
Product Citations

Product Details of [ 344-19-4 ]

CAS No. :344-19-4 MDL No. :MFCD00142845
Formula : C6H4Cl2FN Boiling Point : No data available
Linear Structure Formula :- InChI Key :YAUYKCFMKMZTEX-UHFFFAOYSA-N
M.W : 180.01 Pubchem ID :2774008
Synonyms :

Calculated chemistry of [ 344-19-4 ]      Expand+

Physicochemical Properties

Num. heavy atoms : 10
Num. arom. heavy atoms : 6
Fraction Csp3 : 0.0
Num. rotatable bonds : 0
Num. H-bond acceptors : 1.0
Num. H-bond donors : 1.0
Molar Refractivity : 40.82
TPSA : 26.02 ?2

Pharmacokinetics

GI absorption : High
BBB permeant : Yes
P-gp substrate : No
CYP1A2 inhibitor : Yes
CYP2C19 inhibitor : No
CYP2C9 inhibitor : No
CYP2D6 inhibitor : No
CYP3A4 inhibitor : No
Log Kp (skin permeation) : -5.15 cm/s

Lipophilicity

Log Po/w (iLOGP) : 1.9
Log Po/w (XLOGP3) : 3.16
Log Po/w (WLOGP) : 3.14
Log Po/w (MLOGP) : 3.1
Log Po/w (SILICOS-IT) : 2.84
Consensus Log Po/w : 2.83

Druglikeness

Lipinski : 0.0
Ghose : None
Veber : 0.0
Egan : 0.0
Muegge : 2.0
Bioavailability Score : 0.55

Water Solubility

Log S (ESOL) : -3.39
Solubility : 0.0732 mg/ml ; 0.000407 mol/l
Class : Soluble
Log S (Ali) : -3.38
Solubility : 0.0756 mg/ml ; 0.00042 mol/l
Class : Soluble
Log S (SILICOS-IT) : -3.55
Solubility : 0.051 mg/ml ; 0.000283 mol/l
Class : Soluble

Medicinal Chemistry

PAINS : 0.0 alert
Brenk : 1.0 alert
Leadlikeness : 1.0
Synthetic accessibility : 1.52

Safety of [ 344-19-4 ]

Signal Word:Danger Class:6.1
Precautionary Statements:P501-P261-P270-P271-P264-P280-P337+P313-P305+P351+P338-P361+P364-P332+P313-P301+P310+P330-P302+P352+P312-P304+P340+P311-P403+P233-P405 UN#:2811
Hazard Statements:H301+H311+H331-H315-H319 Packing Group:Ⅲ
GHS Pictogram:

Application In Synthesis of [ 344-19-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 344-19-4 ]

[ 344-19-4 ] Synthesis Path-Downstream   1~10

  • 1
  • [ 392-16-5 ]
  • [ 344-19-4 ]
  • 2
  • [ 344-19-4 ]
  • [ 108-24-7 ]
  • [ 392-16-5 ]
  • 3
  • [ 371-40-4 ]
  • [ 344-19-4 ]
  • 4
  • [ 344-19-4 ]
  • [ 100754-92-5 ]
  • [ 127792-44-3 ]
  • 5
  • [ 344-19-4 ]
  • [ 127792-50-1 ]
  • [ 127792-42-1 ]
  • 7
  • [ 344-19-4 ]
  • (2,6-dichloro-4-fluorophenyl)hydrazine hydrochloride [ No CAS ]
YieldReaction ConditionsOperation in experiment
96% Preparation 10 2,6 Dichloro-4-fluoro-phenylhydrazine hydrochlorideTo a 0 0C solution of 2,6 Dichloro-4-fluorophenylamine (3.0 g, 16.6 mmol) in 12 M HCl (30 mL) and TFA (20 mL) is added slowly and dropwise NaNO2 (20 mmol, 1.37 mL) in water (6 mL). The reaction is stirred at 0 0C for 1 h. A solution of SnCl2 (5.74 g, 25.6 mmol) in 12 M HCl (16 mL) is added over 15 minutes. The ice bath is removed and <n="24"/>the reaction is stirred for 18 h. The reaction is filtered and the solid is washed with isopropyl alcohol. The solid is dried to yield the title compound (3.0 g, 96 %). LC-ES/MS m/e 194.0 (M+ 1)
Step 1: (2,6-dichloro-4-fluorophenyl)hydrazine hydrochloride To a - 5 C solution (internal temperature, wet ice/acetone bath) of <strong>[344-19-4]2,6-dichloro-4-fluoroaniline</strong> (3.0 g, 17 mmol) in 37 % hydrochloric acid (30 mL) and trifluoroacetic acid (20 mL) was added dropwise an aqueous solution of sodium nitrite (1.4 g, 20 mmol, 6 mL water). The reaction was stirred for 90 minutes, then a solution of stannous chloride dihydrate (5.6 g, 25 mmol) in 37 % hydrochloric acid (16 mL) was added over 15 minutes, keeping the internal temperature ? 2 C. The mixture was stirred overnight at room temperature. The mixture was filtered and the collected solid was washed with isopropyl alcohol and dried under house vacuum to provide the title compound. LCMS-ESI+ (m/z): [M+H]+ calcd for C6H6Cl2FN2: 195.0; found: 194.9.
  • 8
  • [ 344-19-4 ]
  • [ 88972-04-7 ]
YieldReaction ConditionsOperation in experiment
71% PREPARATION CXXXVI; 2,6-dichloro-4-fluorobenzenesulphonyl chloride; A solution of 4.75 g (25 mM) of <strong>[344-19-4]2,6-dichloro-4-fluoroaniline</strong> in 50 ml of dichloromethane are added, at -15 C., to 4.75 ml of boron trifluoride etherate. 5 ml of tetrahydrofuran are added to dissolve the precipitate formed, then, slowly, 3.6 ml of t-butyl nitrite in solution in 25 ml of dichloromethane are added. The reaction mixture is agitated 10 minutes at -15 C. and then 20 minutes at +5 C. 200 ml of pentane are added, and agitation is maintained at 0 C. for 30 min and the precipitate is filtered off. After drying, 7.2 g of the diazonium salt are obtained. This salt is dissolved in 30 ml of acetonitrile and is added, at 10 C., to a mixture of a solution of sulphur dioxide in 90 ml of acetic acid to which 1.4 g of anhydrous copper (II) chloride and 23 ml of concentrated hydrochloric acid have been added. The reaction mixture is agitated 30 min at ambient temperature and then concentrated under reduced pressure. The residue from evaporation is taken up into 60 ml of dichloromethane and the insoluble salts are removed by filtration. The filtrate is concentrated under reduced pressure to give 4.71 g of the product sought after as orange crystals (yield=71%). M.Pt.=57 C.
  • 9
  • tin(II)chloride dihydrate [ No CAS ]
  • [ 344-19-4 ]
  • 2,6-DICHLORO-4-FLUOROPHENYLHYDRAZINE [ No CAS ]
YieldReaction ConditionsOperation in experiment
With sodium hydroxide; sodium nitrite; In hydrogenchloride; water; PREPARATION OF 2,6-DICHLORO-4-FLUOROPHENYLHYDRAZINE (INTERMEDIATE NO. 2) 9.0 g (0.05 mol) of <strong>[344-19-4]2,6-dichloro-4-fluoroaniline</strong> was added to 50 ml of concentrated hydrochloric acid, and a solution of 3.8 g (0.055 mol) of sodium nitrite in 25 ml of water was dropwise added thereto at a temperature of from 0 to 5 C. After completion of the dropwise addition, the mixture was stirred at the same temperature for further 1 hour. Insolubles were removed by filtration, and the filtrate was dropwise added at a temperature of from 0 to 10 C. to a solution of 33.8 g (0.15 mol) of stannous chloride dihydrate in 50 ml of concentrated hydrochloric acid. After completion of the dropwise addition, the mixture was stirred at the same temperature for further 2 hours. The precipitated hydrochloride was collected by filtration, and 50 ml of water was added thereto. The mixture was made alkaline with an addition of 20% sodium hydroxide, and the precipitated solid was extracted with ethyl ether. The ethyl ether layer was washed with water and dried over anhydrous sodium sulfate. Then, the solvent was distilled off. The residue thereby obtained was washed with cold n-hexane to obtain 6.9 g (yield: 70.4%) of the desired compound as white feather-like crystals. Melting point: 117-119 C.
  • 10
  • [ 1378039-78-1 ]
  • [ 344-19-4 ]
  • [ 1378040-07-3 ]
YieldReaction ConditionsOperation in experiment
With titanium tetrachloride; triethylamine; In dichloromethane; at 0 - 20℃; for 5h; Method 2:Example 43 :2-(2,6-Dichloro-4-fluorophenyl)-7-fluoro-2H-pyrazolo[4,3-c]pyridin-4-yl]-(6-methylpyrimidin-4-yl)- amineStep 1 : [l-(4-Azido-5-fluoropyridin-3-yl)-meth-(￡)-ylidene]-(2,6-dichloro-4-fluorophenyl)-amineTo a cooled (0 C) solution of 4-azido-5-fluoro-pyridine-3-carbaldehyde (2.44 g, 14.7 mmol), 2,6-dichloro-4- fluorophenylamine (2.65 g, 14.7 mmol) and triethylamine (6.1 mL, 44 mmol) in DCM (50 mL) was added titanium tetrachloride (1M in DCM, 8.8 mL, 8.8 mmol) dropwise. The reaction mixture was stirred at 0 C for 1 hour, warmed to room temperature, and stirred for a further 4 hours. The mixture was concentrated under reduced pressure. The residue was dissolved in toluene and filtered through Celite. The filtrate was concentrated under to dryness under reduced pressure to afford the title compound that was used without further purification.
Recommend Products
Same Skeleton Products

Technical Information

Historical Records

Related Functional Groups of
[ 344-19-4 ]

Fluorinated Building Blocks

Chemical Structure| 2106-02-7

[ 2106-02-7 ]

2-Chloro-4-fluoroaniline

Similarity: 0.90

Chemical Structure| 36556-56-6

[ 36556-56-6 ]

2-Chloro-4,6-difluoroaniline

Similarity: 0.87

Chemical Structure| 363-51-9

[ 363-51-9 ]

2-Chloro-6-fluoroaniline

Similarity: 0.87

Chemical Structure| 2613-32-3

[ 2613-32-3 ]

2-Chloro-4,5-difluoroaniline

Similarity: 0.87

Chemical Structure| 452-83-5

[ 452-83-5 ]

2-Chloro-5-fluoroaniline

Similarity: 0.86

Aryls

Chemical Structure| 2106-02-7

[ 2106-02-7 ]

2-Chloro-4-fluoroaniline

Similarity: 0.90

Chemical Structure| 36556-56-6

[ 36556-56-6 ]

2-Chloro-4,6-difluoroaniline

Similarity: 0.87

Chemical Structure| 363-51-9

[ 363-51-9 ]

2-Chloro-6-fluoroaniline

Similarity: 0.87

Chemical Structure| 2613-32-3

[ 2613-32-3 ]

2-Chloro-4,5-difluoroaniline

Similarity: 0.87

Chemical Structure| 452-83-5

[ 452-83-5 ]

2-Chloro-5-fluoroaniline

Similarity: 0.86

Chlorides

Chemical Structure| 2106-02-7

[ 2106-02-7 ]

2-Chloro-4-fluoroaniline

Similarity: 0.90

Chemical Structure| 36556-56-6

[ 36556-56-6 ]

2-Chloro-4,6-difluoroaniline

Similarity: 0.87

Chemical Structure| 363-51-9

[ 363-51-9 ]

2-Chloro-6-fluoroaniline

Similarity: 0.87

Chemical Structure| 2613-32-3

[ 2613-32-3 ]

2-Chloro-4,5-difluoroaniline

Similarity: 0.87

Chemical Structure| 452-83-5

[ 452-83-5 ]

2-Chloro-5-fluoroaniline

Similarity: 0.86

Amines

Chemical Structure| 2106-02-7

[ 2106-02-7 ]

2-Chloro-4-fluoroaniline

Similarity: 0.90

Chemical Structure| 36556-56-6

[ 36556-56-6 ]

2-Chloro-4,6-difluoroaniline

Similarity: 0.87

Chemical Structure| 363-51-9

[ 363-51-9 ]

2-Chloro-6-fluoroaniline

Similarity: 0.87

Chemical Structure| 2613-32-3

[ 2613-32-3 ]

2-Chloro-4,5-difluoroaniline

Similarity: 0.87

Chemical Structure| 452-83-5

[ 452-83-5 ]

2-Chloro-5-fluoroaniline

Similarity: 0.86

; ;