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In tetrahydrofuran; (2S)-N-methyl-1-phenylpropan-2-amine hydrate;
Step 2 trans-1,4-Bis(hydroxymethyl)cyclohexane Under argon stream, a suspension of 2.96 g of lithium aluminum hydride in 100 mL of anhydrous tetrahydrofuran was treated dropwise with a solution of 3.9 g of trans-1,4-cyclohexanedicarboxylic acid dimethyl ester in anhydrous tetrahydrofuran at -20° C., and stirred for 2.5 hours. The reaction solution was combined with ice water to complete the reaction, and the insolubles were filtered off through Celite. After drying over magnesium sulfate, the residue was concentrated to obtain 2.80 g of the desirable compound.
With copper chromium; hydrogen; at 210℃; under 152940.0 Torr;
To produce cyclohexane dimethanol, a fixed-bed continuous reactor as shown in Figure 1 was used. The fixed-bed continuous-reaction equipment includes a raw material storage container for storing raw materials, a pump for supplying high-pressure raw material and hydrogen, a fixed-bed continuous reactor filled with copper chromium (CuCr) catalyst, and a separator for separating cyclohexanedimethanol and hydrogen. By this fixed-bed continuous reaction equipment to use the hydrogenation the proportion of trans isomers is 20percent by mole of dimethyl 1,4-cyclohexane dicarboxylate under the conditions described in Table 1 was produced 1,4-cyclohexanedimethanol. 1,4- dimethylcyclohexanedicarboxylate in which the rate of the trans isomer was 60 mole percent was hydrogenated at the Comparative Example 1 and same condition and the cyclohexane dimethanol was produced.
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