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1-[1-(pyrimidin-2-yl)-1H-indol-2-yl]octan-3-one[ No CAS ]
Yield
Reaction Conditions
Operation in experiment
89%
With silver hexafluoroantimonate; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; In water; at 80℃; for 12h;Schlenk technique; Green chemistry;
General procedure: Heterocycles 1 (0.2mmol, 1.0 equiv), allylic alcohols 2 (0.4 mmol, 2.0 equiv), [Cp*RhCl2]2 (2.5mol %), AgSbF6 (0.02mmol, 10mol %) and H2O (2mL) were charged into a Schlenk tube under air. The reaction mixture was stirred for 12hat 80C. After the reaction was complete, the mixture was extracted with CH2Cl2 three times. The combined organic layer was dried with anhydrous Na2SO4 and evaporated in vacuum. The crude product was purified by flash chromatography on silica gel using hexane/ethyl acetate as the eluent to give the pure product 3.
89%
With silver hexafluoroantimonate; at 20℃; for 24h;
To the polyethylene glycol-400 catalytic system obtained in Example 10 was added 1 mmol of N-pyrimidine indole and 2 mmol of 1-octen-3-ol,Stir at room temperature for 24 hours, monitor the progress of the reaction by TLC,After the reaction is complete, extract with ether three times,The obtained polyethylene glycol-400 catalytic system is reused,Put into the next experiment, combine the ether solution and concentrate, and separate it by column chromatography to obtain 287mg of light yellow oily liquid.The yield is 89%, the structural formula of the resulting product is as follows,The obtained polyethylene glycol-400 catalytic system was reused and put into the next experiment:
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