天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

Home Cart 0 Sign in  

[ CAS No. 3373-00-0 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
Chemical Structure| 3373-00-0
Chemical Structure| 3373-00-0
Structure of 3373-00-0 * Storage: {[proInfo.prStorage]}

Please Login or Create an Account to: See VIP prices and availability

Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Search after Editing

* Storage: {[proInfo.prStorage]}

* Shipping: {[proInfo.prShipping]}

Quality Control of [ 3373-00-0 ]

Related Doc. of [ 3373-00-0 ]

Alternatived Products of [ 3373-00-0 ]
Product Citations

Product Details of [ 3373-00-0 ]

CAS No. :3373-00-0 MDL No. :MFCD00800243
Formula : C9H11NO Boiling Point : -
Linear Structure Formula :- InChI Key :CTJSPUFGQNVJJP-UHFFFAOYSA-N
M.W : 149.19 Pubchem ID :76897
Synonyms :
Chemical Name :6-Hydroxy-1,2,3,4-tetrahydroquinoline

Calculated chemistry of [ 3373-00-0 ]      Expand+

Physicochemical Properties

Num. heavy atoms : 11
Num. arom. heavy atoms : 6
Fraction Csp3 : 0.33
Num. rotatable bonds : 0
Num. H-bond acceptors : 1.0
Num. H-bond donors : 2.0
Molar Refractivity : 48.36
TPSA : 32.26 ?2

Pharmacokinetics

GI absorption : High
BBB permeant : Yes
P-gp substrate : No
CYP1A2 inhibitor : No
CYP2C19 inhibitor : No
CYP2C9 inhibitor : No
CYP2D6 inhibitor : No
CYP3A4 inhibitor : No
Log Kp (skin permeation) : -5.84 cm/s

Lipophilicity

Log Po/w (iLOGP) : 1.52
Log Po/w (XLOGP3) : 1.93
Log Po/w (WLOGP) : 1.18
Log Po/w (MLOGP) : 1.4
Log Po/w (SILICOS-IT) : 1.97
Consensus Log Po/w : 1.6

Druglikeness

Lipinski : 0.0
Ghose : None
Veber : 0.0
Egan : 0.0
Muegge : 1.0
Bioavailability Score : 0.55

Water Solubility

Log S (ESOL) : -2.38
Solubility : 0.615 mg/ml ; 0.00413 mol/l
Class : Soluble
Log S (Ali) : -2.23
Solubility : 0.876 mg/ml ; 0.00587 mol/l
Class : Soluble
Log S (SILICOS-IT) : -2.68
Solubility : 0.309 mg/ml ; 0.00207 mol/l
Class : Soluble

Medicinal Chemistry

PAINS : 0.0 alert
Brenk : 1.0 alert
Leadlikeness : 1.0
Synthetic accessibility : 1.45

Safety of [ 3373-00-0 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 3373-00-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 3373-00-0 ]

[ 3373-00-0 ] Synthesis Path-Downstream   1~11

  • 1
  • [ 580-16-5 ]
  • [ 3373-00-0 ]
YieldReaction ConditionsOperation in experiment
With hydrogen;palladium(IV) oxide; In methanol; The starting material was prepared as follows: 6-Hydroxyquinoline (1 g, 6.9 mmol) was dissolved in methanol and hydrogenated at 3 atmospheres pressure with platinum(IV) oxide (276 mg) over 24 hours. The catalyst was removed by filtration over a pad of celite and the solvent was evaporated. The solid was washed with ether to give 6-hydroxy-(1,2,3,4)-tetrahydroquinoline (698 mg, 68 %). 1H NMR Spectrum (DMSOd6) 1.75 (m, 2H); 2.60 (m, 2H); 3.05 (m, 2H); 4.90 (br s, 1H); 6.30 (m, 3H); 8.25 (br s, 1H)
YieldReaction ConditionsOperation in experiment
1.9 In analogy to example 1.8, 6-(5-Bromo-pentyloxy)-3,4-dihydro-2H-quinoline-1-carboxylic acid 4-chloro-phenyl ester and N-allylmethylamine were converted to yield 6-[5-(Allyl-methyl-amino)-pentyloxy]-3,4-dihydro-2H-quinoline-1-carboxylic acid 4-chloro-phenyl ester as colorless oil, MS: 443 (MH+, 1Cl).
  • 5
  • [ 580-16-5 ]
  • [ 7664-93-9 ]
  • [ 7732-18-5 ]
  • [ 3373-00-0 ]
  • 6
  • [ 580-16-5 ]
  • [ 7732-18-5 ]
  • KOH-solution [ No CAS ]
  • [ 3373-00-0 ]
  • 7
  • [ 3373-00-0 ]
  • [ 24424-99-5 ]
  • [ 327044-56-4 ]
YieldReaction ConditionsOperation in experiment
76.7% With sodium hydroxide; In 1,4-dioxane; water; at 20℃; Procedure E: 1, 2,3, 4-tetrahydro-quinolin-6-ol (CAS Registry Number 3373-00-0) (25 g, 172.9 mmol) is treated with di-tert-butyl dicarbonate (56.6 g, 259.4 mmol) in a solvent mixture of dioxane (200 mL) and 1N [NAOH] (200 [ML),] and reaction mixture allowed to stir at room temperature overnight. The layers are separated, and the aqueous layer is washed with ethyl acetate (2X). The organic layers are combined and washed with brine [(1X),] dried over [NA2S04] and the organic layer evaporated to give a crude oil. Flash chromatography (Biotage, 10% EtOAc/hexanes) gives the desired material (33.0 g, 76.7% yld).
With triethylamine; for 2.0h;Heating / reflux;Product distribution / selectivity; 6-Hydroxy-l,2,3,4-tetrahydro quinoline (1 eq), Boc anhydride (1.2 eq) and triethyl amine (1.2 eq) were mixed and heated to refluxed for 2hr. Mixture was quenched in water and product was extracted with EtOAc to afford title compound as oil.Compound was used directly for the next reaction without purification.
  • 8
  • [ 120-15-0 ]
  • [ 3373-00-0 ]
YieldReaction ConditionsOperation in experiment
71.11% With boron tribromide; In dichloromethane; at 0 - 15℃; for 2.0h; Compound 26A (3.00 g, 18.38 mmol) was dissolved in 50 ml of dichloromethane, BBr3 (13.81 g, 55.14 mmol)was added at 0 C, and then stirred at 15 C for 2 hours. The reaction solution was concentrated and the reaction wasquenched by 5 ml of methanol. Saturated sodium bicarbonate solution (20 ml) was added and stirred for 30 min, thenextracted with 20 ml of ethyl acetate three times. The organic phases were combined and dried over anhydrous sodiumsulfate and concentrated to give a crude product. The crude product was purified by silica gel column chromatography(petroleum ether/ethyl acetate was from 3:1 to 1:1) to give compound 26B (1.95 g, the yield was 71.11%).1H NMR (400 MHz, DMSO-d6) 8.24 (s, 1H), 6.22-6.35 (m, 3H), 4.93 (br. s., 1H), 3.02-3.10 (m, 2H), 2.57 (t, J = 6.4 Hz,2H), 1.67-1.80 (m, 2H).
  • 10
  • [ 3373-00-0 ]
  • 1-ethyl-6-(3-piperidin-1-yl-propoxy)-1,2,3,4-tetrahydro-quinoline [ No CAS ]
  • 11
  • [ 3373-00-0 ]
  • [6-(3-piperidin-1-yl-propoxy)-3,4-dihydro-2<i>H</i>-quinolin-1-yl]-thiophen-2-yl-methanone [ No CAS ]
Recommend Products
Same Skeleton Products

Technical Information

Historical Records

Related Functional Groups of
[ 3373-00-0 ]

Alcohols

Chemical Structure| 172078-33-0

[ 172078-33-0 ]

Indolin-5-ol

Similarity: 0.94

Chemical Structure| 6640-50-2

[ 6640-50-2 ]

1,2,3,4-Tetrahydro-8-hydroxyquinoline

Similarity: 0.91

Chemical Structure| 4770-37-0

[ 4770-37-0 ]

Indolin-6-ol

Similarity: 0.91

Chemical Structure| 58196-33-1

[ 58196-33-1 ]

7-Hydroxy-1,2,3,4-tetrahydroquinoline

Similarity: 0.87

Chemical Structure| 1125-40-2

[ 1125-40-2 ]

3-Methyl-1H-indol-5-ol

Similarity: 0.87

Related Parent Nucleus of
[ 3373-00-0 ]

Tetrahydroquinolines

Chemical Structure| 120-15-0

[ 120-15-0 ]

6-Methoxy-1,2,3,4-tetrahydroquinoline

Similarity: 0.94

Chemical Structure| 6640-50-2

[ 6640-50-2 ]

1,2,3,4-Tetrahydro-8-hydroxyquinoline

Similarity: 0.91

Chemical Structure| 19500-61-9

[ 19500-61-9 ]

7-Methoxy-1,2,3,4-tetrahydroquinoline

Similarity: 0.91

Chemical Structure| 19500-62-0

[ 19500-62-0 ]

7-Methoxy-1,2,3,4-tetrahydroquinoline hydrochloride

Similarity: 0.89

Chemical Structure| 58196-33-1

[ 58196-33-1 ]

7-Hydroxy-1,2,3,4-tetrahydroquinoline

Similarity: 0.87

; ;