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CAS No. : | 2932-65-2 | MDL No. : | MFCD00041359 |
Formula : | C11H14O | Boiling Point : | No data available |
Linear Structure Formula : | - | InChI Key : | ZNBVIYMIVFKTIW-UHFFFAOYSA-N |
M.W : | 162.23 | Pubchem ID : | 76236 |
Synonyms : |
|
Signal Word: | Warning | Class: | |
Precautionary Statements: | P280-P305+P351+P338 | UN#: | |
Hazard Statements: | H302-H315-H319-H335 | Packing Group: | |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With hydrogenchloride;aluminium chloride; In dichloromethane; water; | (a) A solution of n-propylbenzene (24 g) and acetyl chloride (14.5 ml) in dichloromethane (80 ml) was added dropwise with cooling to a suspension of anhydrous aluminium chloride (27 g) in dichloromethane (70 ml). The resulting solution was stirred at room temperature for one hour and poured into ice/water (250 ml) containing concentrated hydrochloric acid (10 ml). The organic layer was separated and the aqueous layer was extracted with dichloromethane (3*50 ml). The combined organic fractions were washed with water and saturated aqueous ammonium chloride, dried (magnesium sulphate) and evaporated under reduced pressure to afford a yellow oil which was distilled under reduced pressure to afford 4-n-propyl acetophenone (26 g), b.p. 98 C. at 3 mm Hg. | |
aluminium trichloride; In carbon disulfide; | Step A1: The production of 4-n-propylacetophenone Crushed anhydrous aluminium trichloride (1.28 mole) was suspended in dry carbon disulphide (348 ml). Acetylchloride (1.1 mole) and n-propylbenzene (1.0 mole) was dissolved in dry carbon disulphide (348 ml) and added to the suspension of aluminium trichloride under anhydrous conditions. The mixture was then left to stir overnight. The solvent was distilled from the reaction mixture and the viscous residue poured onto crushed ice and stirred for 0.5 hours. The product was extracted into ether and the extract washed with water and dried (Na2 SO4). The ether was removed by distillation and the oily residue distilled. The product had mpt 132 C. at 0.1 mm Hg. |
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