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[ CAS No. 288-36-8 ] {[proInfo.proName]}

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Chemical Structure| 288-36-8
Chemical Structure| 288-36-8
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Product Citations

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Zhang, Yue-Rou ; Yuan, Dao-Fu ; Wang, Lai-Sheng DOI: PubMed ID:

Abstract: Although the adiabatic potential energy surfaces defined by the Born-Oppenheimer approximation are the cornerstones for understanding the electronic structure and spectroscopy of mol. systems, nonadiabatic effects due to the coupling of electronic states by nuclear motions are common in complex mol. systems. The nonadiabatic effects were so strong in the 1,2,3-triazolyl radical (C2H2N3) that the photoelectron spectrum of the triazolide anion was rendered unassignable and could only be understood using nonadiabatic calculations, involving the four low-lying electronic states of triazolyl. Using photodetachment spectroscopy and resonant photoelectron imaging of cryogenically cooled anions, we are able to completely unravel the complex vibronic levels of the triazolyl radical. Photodetachment spectroscopy reveals a dipole-bound state for the triazolide anion at 172 cm-1 below the detachment threshold and 32 vibrational Feshbach resonances. Resonant photoelectron imaging is conducted by tuning the detachment laser to each of the Feshbach resonances. Combining the photodetachment spectrum and the resonant photoelectron spectra, we are able to assign all 28 vibronic peaks resolved for the triazolyl radical. Fundamental frequencies for 12 vibrational modes of the ground state of the triazolyl radical are measured exptl. The current study provides unprecedented exptl. vibronic information, which will be valuable to verify theor. models to treat nonadiabatic effects involving multiple electronic states.

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Product Details of [ 288-36-8 ]

CAS No. :288-36-8 MDL No. :MFCD00014490
Formula : C2H3N3 Boiling Point : -
Linear Structure Formula :- InChI Key :QWENRTYMTSOGBR-UHFFFAOYSA-N
M.W : 69.07 Pubchem ID :67516
Synonyms :

Calculated chemistry of [ 288-36-8 ]      Expand+

Physicochemical Properties

Num. heavy atoms : 5
Num. arom. heavy atoms : 5
Fraction Csp3 : 0.0
Num. rotatable bonds : 0
Num. H-bond acceptors : 2.0
Num. H-bond donors : 1.0
Molar Refractivity : 16.38
TPSA : 41.57 ?2

Pharmacokinetics

GI absorption : High
BBB permeant : No
P-gp substrate : No
CYP1A2 inhibitor : No
CYP2C19 inhibitor : No
CYP2C9 inhibitor : No
CYP2D6 inhibitor : No
CYP3A4 inhibitor : No
Log Kp (skin permeation) : -6.96 cm/s

Lipophilicity

Log Po/w (iLOGP) : 0.0
Log Po/w (XLOGP3) : -0.33
Log Po/w (WLOGP) : -0.2
Log Po/w (MLOGP) : -1.1
Log Po/w (SILICOS-IT) : 1.21
Consensus Log Po/w : -0.08

Druglikeness

Lipinski : 0.0
Ghose : None
Veber : 0.0
Egan : 0.0
Muegge : 2.0
Bioavailability Score : 0.55

Water Solubility

Log S (ESOL) : -0.8
Solubility : 10.9 mg/ml ; 0.158 mol/l
Class : Very soluble
Log S (Ali) : -0.08
Solubility : 57.2 mg/ml ; 0.828 mol/l
Class : Very soluble
Log S (SILICOS-IT) : -0.71
Solubility : 13.3 mg/ml ; 0.193 mol/l
Class : Soluble

Medicinal Chemistry

PAINS : 0.0 alert
Brenk : 0.0 alert
Leadlikeness : 1.0
Synthetic accessibility : 1.32

Safety of [ 288-36-8 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 288-36-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 288-36-8 ]

[ 288-36-8 ] Synthesis Path-Downstream   1~12

  • 1
  • [ 288-36-8 ]
  • [ 15294-81-2 ]
YieldReaction ConditionsOperation in experiment
93% With bromine; In water; at 50℃; for 41.5h; Example 120: Preparation of 4,5-dibromo-lH-pi,2,31triazoleRr Br. BrN^ NH *" ' \\V NVNH <n="69"/>To a solution of IH-[1, 2,3]triazole (1.26 ml, 21.7 mmol) in water (10 ml) at 5tfC, was added bromine (1.5 ml, 29 mmol). The reaction mixture was stirred at 5CPC for 1.5 hours. The white solid (2.375 g) was isolated via filtration and washed with water (5 ml). To the combined filtrates was added more bromine (1.5 ml, 29 mmol). The reaction mixture was stirred at room temperature for 20 hours. More white solid (1.83 g) was isolated via filtration and washed with water (5 ml). To the combined filtrates was added more bromine (1.5 ml, 29 mmol). The reaction mixture was stirred at room temperature for 20 hours. More white solid (375 mg) was isolated via filtration and washed with water (5ml). The white solids were combined and dried to give 4,5-dibromo- IH-[1, 2,3]- triazole (4.92 g, 93percent yield). M.p. 194.7C.
90.39% With bromine; In water; at 25 - 45℃; for 17h; Intermediate 14f (0556) 4,5-Dibromo-lH-triazole (0557) Br2 (930 g, 5.82 mol) was added dropwise to a stirred solution of lH-triazole (300.00 g, 4.34 mol, 252.10 mL) in H20 (2 L) at 40 to 45 °C. The resulting solution was stirred for a further 1 hour. The precipitate was filtered off and further Br2 (617.28 g, 3.86 mol) was added to the filtrate, then it was kept at 25 °C for 16 hours. A second precipitate was filtered off. The combined filtered off solids were washed with water (1 L x 3), dried under vacuum and re-crystallized from MeOH (-400 mL) to give 4,5-dibromo-lH-triazole (Intermediate 14f; 890 g, 90.39percent yield) as an off-white solid, m/z (ES+) [M+H]+ (0558) 226/228/230.
With bromine; In water; at 20 - 50℃; for 41.5h; Example 159: Preparation of 4,5-dibromo- IH-[1, 2,3 ItriazoleTo a solution of IH-[1, 2,3]triazole (1.26 ml, 21.7 mmol) in water (10 ml) at 50°C, was added bromine (1.5 ml, 29 mmol). The reaction mixture was stirred at 50°C for 1.5 hours. The white solid (2.375 g) was isolated via filtration and washed with water (5 ml). To the combined filtrates was added more bromine (1.5 ml, 29 mmol). The reaction mixture was stirred at room temperature for 20 hour. More white solid (1.83 g) was isolated via filtration and washed with water (5 ml). To the combined filtrates was added more bromine (1.5 ml, 29 mmol). The reaction mixture was stirred at room temperature for 20 hours. More white solid (375 mg) was isolated via filtration and washed with <n="113"/>water (5ml). The white solids were combined and dried to give 4,5-dibromo- IH-[1, 2,3]- triazole (4.92 g, 93percent yield). M.p. 194.70C.
With bromine; In water; at 40℃; for 2h; Bromine (2.2 mL, 43.4 mmol) was added cautiously to a solution of 1H-1,2,3- triazole (2 g, 29.0 mmol) in water (10 mL) at 40°C. The resulting mixture was stirred for 2 hrs at 40°C, then allowed to cool and stood overnight at room temperature. The precipitate was isolated by filtration, washed with water (2x10 mL), and dried in the vacuum oven to give 4,5- dibromo-lH-l,2,3-triazole as a light brown solid. (M+H 225.6; LCMS method 2).

  • 2
  • [ 288-36-8 ]
  • [ 15294-81-2 ]
  • 1,4,5-tribromo-1<i>H</i>-[1,2,3]triazole [ No CAS ]
  • 3
  • [ 288-36-8 ]
  • [ 22300-52-3 ]
YieldReaction ConditionsOperation in experiment
95% With bromine; In water; at 50℃; Into a 3000-mL 3-necked round-bottom flask, was placed 2H-1,2,3-triazole (100 g, 1.45 mol, 1.00 equiv), water (1000 mL), Br2 (522 g, 3.27 mol, 2.25 equiv). The resulting solution was stirred overnight at 50 C. in an oil bath. The reaction was then quenched by the addition of 1000 mL of Na2SO3 (aq). The solid was collected by filtration and dried in an oven under reduced pressure. This resulted in 313 g (95%) of 4,5-dibromo-2H-1,2,3-triazole as a white solid.
60.8% With bromine; In water; at 0 - 20℃; 4,5-dibromo-2H-l,2,3-triazole. Bromine (15 mL) was added dropwise to a stirred solution of 2H-l,2,3-triazole (15.0 g, 217 mmol) in water (200 mL) at 0C. Once addition was completed, the mixture was stirred for 12 hours at room temperature. The resultant mixture was filtered off and washed with water, dried over sodium sulfate and recrystallized from methanol to afford 4,5-dibromo-2H-l,2,3-triazole as a dark brown solid (29.8 g, 60.8%).
49% With bromine; In water; at 0 - 20℃; [0260] Bromine (11.59 g, 73.35 mmol) was added dropwise to a 0 C solution of 2H-l,2,3-triazole (5.00 g, 72.46 mmol) in water (50 mL), and the resulting solution was allowed to warm to room temperature and stir overnight. The precipitate was collected by filtration and dried to afford 4,5- dibromo-2H-l ,2,3-triazole (8.00 g, 49%) as a white solid. MS (ESI, pos. ion) m/z 228, 226, 230 [M+H]+.
With bromine; In water; at 0℃; for 7h; To a stirred solution of EE-1 (10 g, 144.79 mmol) in water (100 mL) is added EE-2 (13.73 g, 173.75 mmol) dropwise at 0 C and the reaction mixture is stirred at 0 C for 7 hours. The reaction mixture is filtered and extracted with diethyl ether. The combined organics are concentrated in vacuo to yield EE-3.

  • 4
  • [ 288-36-8 ]
  • [ 63558-65-6 ]
  • [ 1356054-95-9 ]
YieldReaction ConditionsOperation in experiment
40% Preparation 57A: 5-Iodo-4-(2H-l,2, -triazol-2-yl)pyrimidine[00244] To a solution of lH-l,2,3-triazole (63.2 mg, 0.915 mmol) in THF (Volume: 241 1 ??), was added portion wise at 0 C, NaH (39.9 mg, 0.998 mmol). The reaction mixture was stirred at that temperature for 30 min, then <strong>[63558-65-6]4-chloro-5-iodopyrimidine</strong> (200 mg, 0.832 mmol) was added. The reaction mixture was allowed to warm to room temperature. To this solution was added saturated aqueous NH4C1 and the mixture was allowed to stir for 5 min at which time it was diluted with ethyl acetate and extracted 2X. The combined organics were washed with brine IX. The organics were dried overNa2S04, filtered and concentrated in vacuo to afford the title compound (90 mg, 40%).
39.6% To a solution of lH-l,2,3-triazole (63.2 mg, 0.915 mmol) in THF (2.4mL), was added, portionwise, at 0C, NaH (39.9 mg, 0.998 mmol). After 30 minutes of stirring,<strong>[63558-65-6]4-chloro-5-iodopyrimidine</strong> (200 mg, 0.832 mmol) was added and the reaction mixture was allowed to come to room temperature, and stirred until judged complete by LCMS.To this was added aqueous saturated NH4C1, and the mixture was allowed to stir for 5 min at which time it was determined that the reaction was complete by LC-MS analysis.This reaction mixture was diluted with ethyl acetate and extracted twice. The combined organics were washed with brine and dried over Na2S04, filtered and concentrated in vacuo. The crude material was dissolved in a minimal amount of hexanes and loaded onto a silica gel column, the column was subsequently eluted as a gradient from 0-15%EtOAc/hexanes. The desired isomer was thus separated from the regioisomeric triazole adduct. The white solid attained (90mg, 39.6%) was determined to be the desired material by 1HNMR and LC/MS. MS (ES): m/z = 274.0 [M+H]+. ? NMR (400 MHz, CCI3D) delta ppm 9.34 (1 H, s), 9.15 (1 H, s), 8.03 (2 H, s).
  • 5
  • [ 288-36-8 ]
  • [ 22300-52-3 ]
YieldReaction ConditionsOperation in experiment
70.8 g With N-Bromosuccinimide; potassium carbonate; In Isopropyl acetate; at 20℃; for 5h; Example 2 Preparation of 4,5-dibromo-2H-1,2,3-triazole NBS (123 g, 690 mmol), K2CO3 (0.8 g, 5.8 mmol) and IPAc (300 mL) are added into a round bottom flask with the internal temperature of the flask keep at 20 C. Then, 1H-1,2,3-triazole (19 mL, 330 mmol) is slowly added in the flask by keeping internal temperature of the reaction mixture below 40 C. The reaction mixture is stirred at 20 C. for 5 h, and then filtered. The filter cake is washed with IPAc (30 mL), and then the filter cake is discarded. The filtrate is washed with 2% NaS2O3 (100 mL). The solvent of the resulting organic layer is distilled under vacuum and the internal temperature of the solvent is kept below 45 C. After the distillation, the obtained product is recrystallized by hexanes (600 mL). The resulting solid is filtered, and the filter cake is washed with hexanes (60 mL). The resulting solid is dried under vacuum at a temperature of no more than 35 C. to afford 70.8 grams of the product. Other R1 heterocycles as contemplated in the present invention can be brominated via similar preparation procedures as outlined above.
  • 6
  • [ 288-36-8 ]
  • [ 36340-61-1 ]
  • [ 1429913-18-7 ]
  • [ 1429913-17-6 ]
YieldReaction ConditionsOperation in experiment
With N-ethyl-N,N-diisopropylamine; at 150℃; for 1.5h; To <strong>[36340-61-1]4-chloro-6-methylpyridin-2-amine</strong> (100 mg, 0.701 mmol) and 1 ,2,3- triazole (0.133 mL, 2.30 mmol) in a pressure tube was added DIPEA (0.185 mL, 1.06 mmol). The reaction mixture was sealed and heated at 150C for 1.5 hours. The reaction mixture was cooled, diluted with DCM (20 mL), and washed with water (10 mL). The organics were separated, dried over sodium sulfate, filtered, and concentrated under reduced pressure. The residue was slurried in 5% methanol/ethyl acetate (5 mL) and sonicated. The mixture was filtered, and the collected solids were dried under reduced pressure to afford 6-methyl-4-(lH- l,2,3-triazol-l-yl)pyridin-2-amine. MS ESI calc'd. for C8H10N5 [M + H]+ 176, found 176. ? NMR (500 MHz, DMSO-d6) delta 8.79 (s, IH), 7.95 (s, IH), 6.90 (s, IH), 6.75 (s, IH), 6.28 (s, 2H), 2.23 (s, 3H). The filtrate was concentrated under reduced pressure, and the residue was purified by silica gel chromatography (2-20% acetone/hexanes, linear gradient) to afford 6-methyl-4-(2H- l,2,3-triazol-2-yl)pyridin-2-amine. MS ESI calc'd. for C8H10N5 [M + H]+ 176, found 176. 1H NMR (500 MHz, DMSO-d6) delta 8.12 (s, 2H), 6.95 (s, IH), 6.85 (s, IH), 6.22 (s, 2H), 2.28 (s, 3H).
  • 7
  • [ 288-36-8 ]
  • [ 54413-93-3 ]
  • [ 1293284-55-5 ]
YieldReaction ConditionsOperation in experiment
With copper(l) iodide; caesium carbonate; In N,N-dimethyl-formamide; at 40 - 70℃; for 0.5h; 2-lodo-5-methoxy benzoic acid (15.0 g; 53.9 mmol) is dissolved in anhydrous DMF (45 ml)followed by the addition of 1H-1,2,3-triazole (7.452 g; 108 mmol) and cesium carbonate (35.155 g; 108 mmol). By the addition of cesium carbonate the temperature of the reaction mixture increases to 4000 and gas evolved from the reaction mixture. Copper(l)iodide (514 mg; 2.7 mmol) is added. This triggers a strongly exothermic reaction and the temperature of the reaction mixture reaches 70°C within a few seconds. Stirring is continued for 30 minutes.Then the DMF is evaporated under reduced pressure followed by the addition of water (170 ml) and EtOAc (90 ml). The mixture is vigorously stirred and by the addition of citric acid monohydrate the pH is adjusted to 3-4. The precipitate is filtered off and washed with water and EtOAc and discarded. The filtrate is poured into a separation funnel and the phases are separated. The water phase is extracted again with EtOAc. The combined organic layers aredried over Mg504, filtered and the solvent is evaporated to give 7.1 g of 5-methoxy-2-(2H-1,2,3-triazol-2-yl)benzoic acid as a white powder of 94percent purity (6 percent impurity is the regioisomerically Ni-linked triazolo-derivative); tR [mm] = 0.60; [M+H] = 220.21
  • 8
  • [ 54413-93-3 ]
  • [ 288-36-8 ]
  • [ 1293284-55-5 ]
  • C10H9N3O3 [ No CAS ]
YieldReaction ConditionsOperation in experiment
With copper(l) iodide; caesium carbonate; In N,N-dimethyl-formamide; at 40 - 70℃; for 0.5h; 1) Synthesis of 5-methoxy-2-(2H-1 ,2,3-triazol-2-yl)benzoic acid2-lodo-5-methoxy benzoic acid (15.0 g; 53.9 mmol) is dissolved in anhydrous DMF (45 ml) followed by the addition of 1 H-1 ,2,3-triazole (7.452 g; 108 mmol) and cesium carbonate (35.155 g; 108 mmol). By the addition of cesium carbonate the temperature of the reaction mixture increases to 40°C and gas evolved from the reaction mixture. Copper(l)iodide (514 mg; 2.7 mmol) is added. This triggers a strongly exothermic reaction and the temperature of the reaction mixture reaches 70°C within a few seconds. Stirring is continued for 30 minutes. Then the DMF is evaporated under reduced pressure followed by the addition of water (170 ml) and EtOAc (90 ml). The mixture is vigorously stirred and by the addition of citric acidmonohydrate the pH is adjusted to 3-4. The precipitate is filtered off and washed with water and EtOAc and discarded. The filtrate is poured into a separation funnel and the phases are separated. The water phase is extracted again with EtOAc. The combined organic layers are dried over MgS04, filtered and the solvent is evaporated to give 7.1 g of 5-methoxy-2-(2H- 1 ,2,3-triazol-2-yl)benzoic acid as a white powder of 94percent purity (6 percent impurity is the regioisomerically N1-linked triazolo-derivative); tR [min] = 0.60; [M+H]+ = 220.21
  • 9
  • [ 288-36-8 ]
  • [ 54413-93-3 ]
  • [ 1293284-55-5 ]
  • C10H9N3O3 [ No CAS ]
YieldReaction ConditionsOperation in experiment
With copper(l) iodide; caesium carbonate; In N,N-dimethyl-formamide; at 40 - 70℃; for 0.5h; 2-lodo-5-methoxy benzoic acid (15.0 g; 53.9 mmol) is dissolved in anhydrous DMF (45 ml) followed by the addition of 1H-1,2,3-triazole (7.452 g; 108 mmol) and cesium carbonate (35.155 g; 108 mmol). By the addition of cesium carbonate the temperature of the reaction mixture increases to 40°C and gas evolved from the reaction mixture. Copper(l)iodide (514 mg; 2.7 mmol) is added. This triggers a strongly exothermic reaction and the temperature ofthe reaction mixture reaches 70°C within a few seconds. Stirring is continued for 30 minutes. Then the DMF is evaporated under reduced pressure followed by the addition of water (170 ml) and EtOAc (90 ml). The mixture is vigorously stirred and by the addition of citric acid monohydrate the pH is adjusted to 3-4. The precipitate is filtered off and washed with water and EtOAc and discarded. The filtrate is poured into a separation funnel and the phases are separated. The water phase is extracted again with EtOAc. The combined organic layers are dried over MgSO4, filtered and the solvent is evaporated to give 7.1 g of 5-methoxy-2-(2H- 1 ,2,3-triazol-2-yl)benzoic acid as a white powder of 94percent purity (6 percent impurity is the regioisomerically Ni-linked triazolo-derivative); tR [mm] = 0.60; [M+H] = 220.21.
  • 10
  • [ 288-36-8 ]
  • [ 13421-00-6 ]
  • [ 1293284-54-4 ]
YieldReaction ConditionsOperation in experiment
68% With trans-N,N'-dimethyl-1,2-cyclohexyldiamine; copper(l) iodide; caesium carbonate; In 1,4-dioxane; water; at 100℃; for 4h; In a round-bottomed flask equipped with an overhead magnetic stirrer, reflux condenser, and nitrogen inlet were added <strong>[13421-00-6]5-chloro-2-iodo<strong>[13421-00-6]benzoic acid</strong></strong> (1 .15 g, 4.07 mmol), copper iodide (0.04 g, 0.2 mmol), and CS2CO3 (2.65 g, 8.14 mmol). To these solids were added dioxane (6 mL), water (0.05 mL), then 1 H-1 ,2,3-triazole (0.47 mL, 8.14 mmol), and finally trans-1 ,2-dimethylcyclohexane-1 ,2-diamine (0.3 mL, 0.81 mmol). The mixture was then warmed to 100 C for 4 hrs. Then the mixture was cooled and then MTBE and of water were added. After vigorous mixing, the layers were separated and the bottom aqueous layer was acidified to pH 2 with 6N HCI. The aqueous was then extracted twice with EtOAc. The combined organic layers were dried, filtered, and concentrated. The oil was stirred overnight in EtOAc (8 mL) and the resulting precipitate was removed by filtration affording a first crop of wanted product(100 mg). The mother-liquors were concentrated and purified by FC on S1O2 column (eluting from DCM to DCM : MeOH: 90: 10) to afford a second batch of the desired product that was mixed with the former to afford 5-chloro-2-(2H-1 ,2,3-triazol-2- yl)<strong>[13421-00-6]benzoic acid</strong> (p120, 620 mg, y=68%). MS (mlz): 223.9 [MH]+
  • 11
  • [ 99368-67-9 ]
  • [ 288-36-8 ]
  • 5-nitro-2-(2H-1,2,3-triazol-2-yl)-3-(trifluoromethyl)pyridine [ No CAS ]
YieldReaction ConditionsOperation in experiment
65.6% With potassium carbonate; In N,N-dimethyl acetamide; at 20℃; for 2.0h; To a solution of <strong>[99368-67-9]2-chloro-5-nitro-3-(trifluoromethyl)pyridine</strong> (1.2 g, 6.84 mmol) and 2H-1,2,3-triazole (0.567 g, 8.20 mmol) in anhydrous DMA (5 mL) was added K2CO3 (1.89 g, 13.67 mmol). The reaction mixture was stirred at room temperature for 2 h. The mixture was filtered and washed with ethyl acetate (10 mL*3). The filtrate was concentrated to dryness to give a crude product.
With potassium carbonate; In tetrahydrofuran; at 20℃; for 1.0h; To a so?ution of 2-choro-5-nitro-3-(trifluoromethy)pyridine (1 .0 g, 4.41 mmo) and K2CQ3 (1.22 g, 883 mmo) in THF (5 m) was added 2H-l ,2,3-triazoe (0.31 m, 5.30 mmo). The reaction mixture was stirred for lh at RT. Water was added and the mixture was extracted with AcOEt. The organic ayer was washed with brine, dried over Na2SO4, fHtered and concentrated under vacuum. The residue was purified by flash co?umn chromatography on sHica ge (cycohexane/AcOEt: 100/0 to 50/50) to afford 5-nitro-2- (2H-1 ,2,3-triazo-2-y 3-(trifluoromethy)pyridine. Miz = 260 [M+H]+, Rt = 0.88 mm (UPLC Method 81), 1H NMR (400 MHz, DMSO-d6) O ppm: 9.69 (d, IH), 9.17 (d, IH), 8,37 (s, 2H).
  • 12
  • [ 13220-33-2 ]
  • [ 55304-72-8 ]
  • [ 288-36-8 ]
  • 3-chloro-6-((1-methylpyrrolidin-3-yl)oxy)-5-nitro-2-(2H-1,2,3-triazol-2-yl)pyridine [ No CAS ]
YieldReaction ConditionsOperation in experiment
To NaH (97 mg, 2.42 mmo 60percent in minera? oN)) in DMF (10 mD at 0°C was added 1- methypyrrodin-3-o (229 mg, 2.20 mmo). After 30 mm of stirring at RT, 2,3,6-trichoro 5nitropyridmne (500 mg, 220 mmoD was added and the reaction mixture was sfirred at RT for 2h, To NaH (97 mg, 2.42 mmo 60percent in minera oN) in DMF (5 mD at 0°C was added 2H-1,2,3-triazoe (157 mg, 220 mmo) and after 10 mm of stirring at RT, the activated 2H1,2,3-triazoe was added at 0°C in the previous reaction mixture. The obtained reaction mixture was stirred at RT overnight. Water was added and the mixture was extracted with AcOEt. The organic phase was washed with brine, dried over Na2SO4 and evaporated. The residue was purified by preparative HPLC (Method A4) to afford 3- choro-6-((1 -methypyrroHdin-3-y)oxy)-5-nitro-2-(2H-1 ,2,3-triazo-2-y)pyridine. M/z = 325-327 [M+H]+, Rt = 0.56 mm (UPLC Method 82).
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