天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

Home Cart 0 Sign in  

[ CAS No. 27243-15-8 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
HazMat Fee +

There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Chemical Structure| 27243-15-8
Chemical Structure| 27243-15-8
Structure of 27243-15-8 * Storage: {[proInfo.prStorage]}

Please Login or Create an Account to: See VIP prices and availability

Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Search after Editing

* Storage: {[proInfo.prStorage]}

* Shipping: {[proInfo.prShipping]}

Quality Control of [ 27243-15-8 ]

Related Doc. of [ 27243-15-8 ]

Alternatived Products of [ 27243-15-8 ]
Product Citations

Product Details of [ 27243-15-8 ]

CAS No. :27243-15-8 MDL No. :MFCD11044492
Formula : C6H6ClNO4 Boiling Point : -
Linear Structure Formula :- InChI Key :OWZGNRBFMASABS-UHFFFAOYSA-N
M.W : 191.57 Pubchem ID :12535337
Synonyms :

Calculated chemistry of [ 27243-15-8 ]      Expand+

Physicochemical Properties

Num. heavy atoms : 12
Num. arom. heavy atoms : 0
Fraction Csp3 : 0.5
Num. rotatable bonds : 3
Num. H-bond acceptors : 4.0
Num. H-bond donors : 0.0
Molar Refractivity : 42.13
TPSA : 63.68 ?2

Pharmacokinetics

GI absorption : High
BBB permeant : No
P-gp substrate : No
CYP1A2 inhibitor : No
CYP2C19 inhibitor : No
CYP2C9 inhibitor : No
CYP2D6 inhibitor : No
CYP3A4 inhibitor : No
Log Kp (skin permeation) : -7.58 cm/s

Lipophilicity

Log Po/w (iLOGP) : 1.16
Log Po/w (XLOGP3) : -0.15
Log Po/w (WLOGP) : -0.55
Log Po/w (MLOGP) : 0.5
Log Po/w (SILICOS-IT) : 0.46
Consensus Log Po/w : 0.28

Druglikeness

Lipinski : 0.0
Ghose : None
Veber : 0.0
Egan : 0.0
Muegge : 1.0
Bioavailability Score : 0.55

Water Solubility

Log S (ESOL) : -0.74
Solubility : 35.2 mg/ml ; 0.184 mol/l
Class : Very soluble
Log S (Ali) : -0.73
Solubility : 35.4 mg/ml ; 0.185 mol/l
Class : Very soluble
Log S (SILICOS-IT) : -0.82
Solubility : 29.3 mg/ml ; 0.153 mol/l
Class : Soluble

Medicinal Chemistry

PAINS : 0.0 alert
Brenk : 2.0 alert
Leadlikeness : 1.0
Synthetic accessibility : 2.2

Safety of [ 27243-15-8 ]

Signal Word:Danger Class:8
Precautionary Statements:P260-P264-P270-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P363-P405-P501 UN#:3261
Hazard Statements:H302-H314 Packing Group:Ⅲ
GHS Pictogram:

Application In Synthesis of [ 27243-15-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 27243-15-8 ]

[ 27243-15-8 ] Synthesis Path-Downstream   1~13

  • 1
  • [ 6066-82-6 ]
  • [ 79-04-9 ]
  • [ 27243-15-8 ]
YieldReaction ConditionsOperation in experiment
53% With triethylamine; In chloroform; at 0℃; for 0.416667h; To a solution of N-hydroxysuccinimide (640.3 mg, 5.56 mmol) in chloroform (8.5 mL) was added triethylamine (861.6 mu, 6.18 mmol) 0 C. Then, a-chloroacetyl chloride was added dropwise over a 5 minute period and stirred for an additional 20 minutes at 0C. The reaction mixture was washed with ice-cold water (15 mL) and brine (15 mL), concentrated to a volume of 1.7 mL in vacuo, then dried with sodium sulfate and filtered. To the resulting solution were added ethyl acetate (170 mu) and hexanes (1.2 mL), and the mixture was cooled down to 0 C stirred for 2 h, and a white solid was precipitated. It was filtered and washed first with ice-cold 10 mL portion of hexanes/ethyl acetate (4: 1), then with 10 mL hexanes/ethyl acetate (9: 1), and finally with hexanes (10 mL, twice). The resulting white solid was dried under house vacuum to yield 2,5-dioxopyrrolidin-l-yl 2-chloroacetate (563.9 mg, 53%). NMR 400 MHz (CDC13) delta 4.37 (s, 2H), 2.87 (s, 4H).
  • 2
  • [ 27243-15-8 ]
  • [ 142182-02-3 ]
  • [ 142182-09-0 ]
  • 3
  • [ 27243-15-8 ]
  • [ 79677-63-7 ]
  • 1-(N-benzyloxycarbonyl-3-iodo-L-tyrosyl)-2-chloroacetylhydrazine [ No CAS ]
  • 4
  • [ 27243-15-8 ]
  • 7-aminomethyl-1-azathioxanthone [ No CAS ]
  • 7-(N-methyl-2-chloro-acetamide)-1-azathioxanthone [ No CAS ]
  • 5
  • [ 27243-15-8 ]
  • [ 1004751-65-8 ]
  • [ 1004751-66-9 ]
  • 6
  • [ 27243-15-8 ]
  • bis(tricarbonyl(η-cyclopentadienyl)tungsten) [ No CAS ]
  • tricarbonylcyclopentadienyltungsten(II) chloride [ No CAS ]
  • (η(5)-cyclopentadienyl)[((succinimidooxy)carbonyl)methyl]tricarbonyltungsten [ No CAS ]
  • 7
  • [ 27243-15-8 ]
  • bis(tricarbonyl(η-cyclopentadienyl)tungsten) [ No CAS ]
  • (η(5)-cyclopentadienyl)[((succinimidooxy)carbonyl)methyl]tricarbonyltungsten [ No CAS ]
  • 8
  • [ 27243-15-8 ]
  • [ 16800-47-8 ]
  • tricarbonylcyclopentadienyltungsten(II) chloride [ No CAS ]
  • (η(5)-cyclopentadienyl)[((succinimidooxy)carbonyl)methyl]tricarbonyltungsten [ No CAS ]
  • 9
  • [ 27243-15-8 ]
  • cyclopentadienylmolybdenum tricarbonyl dimer [ No CAS ]
  • [ 159123-17-8 ]
  • 10
  • [ 27243-15-8 ]
  • [ 31202-69-4 ]
  • C13H23ClN2O5 [ No CAS ]
  • 11
  • 3-trifluoromethyl-4-amino-(methoxyethoxymethoxy)benzene [ No CAS ]
  • [ 27243-15-8 ]
  • 3-trifluoromethyl-4-(chloroethanoylamino)-(methoxyethoxymethoxy)benzene [ No CAS ]
YieldReaction ConditionsOperation in experiment
52% In dichloromethane; at 20℃; 3-Trifluoromethyl-4- (2-chlorocarbamoylmethyl)methoxyethoxymethylbenzene; 3-Trifluoromethyl-4-amino-methoxyethoxymethylbenzene (0.5 g, 0.2 mmol), and N-hydroxysuccinimidyl chloroacetate(0.36 g, 0.2 mmol) were dissolved in dichloromethane (10 cm3), and stirred at room temperature overnight. Solvent was removed and the product purified using column chromatography on silica, (DCM/MeOH, Rf = 0.6, 5% MeOH/DCM) , followed by recrystallisation from hexane/EtOAc to give a white solid, (0.25 g, 52%), m.p. 72-740C, Found C, 45.76%,H, 4.63%, N, 4.21%. C13Hi5NO4F3Cl requires C, 45.72%, H,4.43%, N, 4.13%, m/z (ES+) :341 (M+), 364 [(M+Na)+], deltaH <n="42"/>(CDCl3, 400MHz) : 3.37(s, 3H, 0-CH3) , 3.55(t, J = 4.8 Hz, 2H,0-CH2), 3.81(t, J = 4.8Hz, 2H, O- CH2), 4.22 (s, 2H, CH2Cl),5.28 (s, 2H, 0-CH2-O)7 7.27 (d, J H-H?? = 8Hz, IH, Ar H ortho) , , 7.34 (s, IH, Ar H ortho) . 7.96 (d, JH-H(O) = 8Hz, IH, Ar H meta) , 8.57 (br s, IH, NH) . deltac (CDCl3, ' 100.6Hz) : 43.10(CH2C1), 59.25 (0-CH3), 68.09(0-CH2), 71.68 (0-CH2), 93.82(0-CH2-O), 114.65 (q, 2JCF = 18Hz, CCF3), 120.37(Ar CH),122.97 ( q, 1J0F = 162 Hz, CF3), 126.89 (Ar CH), 127.96 ( ArC), 154.82 (Ar C), 164.63 (Ar CH), 178.54 (C=O)], deltaF(CDCl3, 188MHz) : 61.5 (s) .
  • 12
  • [ 27243-15-8 ]
  • [ 1214248-39-1 ]
  • [ 1214248-45-9 ]
YieldReaction ConditionsOperation in experiment
100% In acetonitrile; at 23℃; for 1h; Step A: 2-Chloro-N-{2-[(R)-(1,2,3,4-tetrahydro-naphthalen-1-yl)amino]-4H-benzo[d][1,3]oxazin-6-yl}-acetamide A mixture of (R)-N2-(1,2,3,4-tetrahydro-naphthalen-1-yl)-4H-benzo[d][1,3]oxazine-2,6-diamine (Example 33) (293 mg, 1 mmol) and chloro-acetic acid 2,5-dioxo-pyrrolidin-1-yl ester (CAS 27243-15-8) (192 mg, 1 mmol) in acetonitrile (2 ml) was stirred at 23 C. for 1 h. Poured onto water and extracted with ethyl acetate, dried the combined organic layers over sodium sulfate, filtered off and evaporated totally to give the title compound as a light red oil (370 mg, 100%, HPLC 1.185 min), MS (ISP) m/e=370.1 [(M+H)+] and 372 [(M+2+H)+].
  • 13
  • [ 27243-15-8 ]
  • [ 56-41-7 ]
  • [ 691-80-5 ]
Recommend Products
Same Skeleton Products

Technical Information

Historical Records

Related Functional Groups of
[ 27243-15-8 ]

Chlorides

Chemical Structure| 64214-66-0

[ 64214-66-0 ]

4-Chloro-N-methoxy-N-methylbutanamide

Similarity: 0.70

Chemical Structure| 67442-07-3

[ 67442-07-3 ]

2-Chloro-N-methoxy-N-methylacetamide

Similarity: 0.54

Chemical Structure| 122334-37-6

[ 122334-37-6 ]

4-Chloro-N-methoxy-N-methylbenzamide

Similarity: 0.51

Chemical Structure| 145959-21-3

[ 145959-21-3 ]

3-Chloro-N-methoxy-N-methylbenzamide

Similarity: 0.51

Amides

Chemical Structure| 14464-29-0

[ 14464-29-0 ]

2,5-Dioxopyrrolidin-1-yl acetate

Similarity: 0.87

Chemical Structure| 30364-60-4

[ 30364-60-4 ]

Bis(2,5-dioxopyrrolidin-1-yl) succinate

Similarity: 0.84

Chemical Structure| 68528-80-3

[ 68528-80-3 ]

Bis(2,5-dioxopyrrolidin-1-yl) octanedioate

Similarity: 0.83

Chemical Structure| 69888-86-4

[ 69888-86-4 ]

2,5-Dioxopyrrolidin-1-yl tetradecanoate

Similarity: 0.83

Chemical Structure| 38862-24-7

[ 38862-24-7 ]

2,5-Dioxopyrrolidin-1-yl acrylate

Similarity: 0.81

Esters

Chemical Structure| 14464-29-0

[ 14464-29-0 ]

2,5-Dioxopyrrolidin-1-yl acetate

Similarity: 0.87

Chemical Structure| 30364-60-4

[ 30364-60-4 ]

Bis(2,5-dioxopyrrolidin-1-yl) succinate

Similarity: 0.84

Chemical Structure| 68528-80-3

[ 68528-80-3 ]

Bis(2,5-dioxopyrrolidin-1-yl) octanedioate

Similarity: 0.83

Chemical Structure| 69888-86-4

[ 69888-86-4 ]

2,5-Dioxopyrrolidin-1-yl tetradecanoate

Similarity: 0.83

Chemical Structure| 38862-24-7

[ 38862-24-7 ]

2,5-Dioxopyrrolidin-1-yl acrylate

Similarity: 0.81

Related Parent Nucleus of
[ 27243-15-8 ]

Pyrrolidines

Chemical Structure| 14464-29-0

[ 14464-29-0 ]

2,5-Dioxopyrrolidin-1-yl acetate

Similarity: 0.87

Chemical Structure| 30364-60-4

[ 30364-60-4 ]

Bis(2,5-dioxopyrrolidin-1-yl) succinate

Similarity: 0.84

Chemical Structure| 68528-80-3

[ 68528-80-3 ]

Bis(2,5-dioxopyrrolidin-1-yl) octanedioate

Similarity: 0.83

Chemical Structure| 69888-86-4

[ 69888-86-4 ]

2,5-Dioxopyrrolidin-1-yl tetradecanoate

Similarity: 0.83

Chemical Structure| 38862-24-7

[ 38862-24-7 ]

2,5-Dioxopyrrolidin-1-yl acrylate

Similarity: 0.81

; ;