天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

Home Cart 0 Sign in  

[ CAS No. 27060-75-9 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
Chemical Structure| 27060-75-9
Chemical Structure| 27060-75-9
Structure of 27060-75-9 * Storage: {[proInfo.prStorage]}

Please Login or Create an Account to: See VIP prices and availability

Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Search after Editing

* Storage: {[proInfo.prStorage]}

* Shipping: {[proInfo.prShipping]}

Quality Control of [ 27060-75-9 ]

Related Doc. of [ 27060-75-9 ]

Alternatived Products of [ 27060-75-9 ]
Product Citations

Product Citations

Qiao Lin ; Ethan H. Spielvogel ; Tianning Diao DOI:

Abstract: The capture of carbon-centered radicals at a nickel(II) center is commonly featured in recent cross-coupling and metallaphotoredox catalytic reactions. Despite its widespread application in catalysis, this fundamental step lacks experimental characterization. This report portrays radical capture at catalytically relevant nickel(II) centers from several aspects, including the structure-activity relationships of the ligands, the mechanism, the kinetics, and the stereoselectivity. Spectroscopic data provide evidence for the formation of a nickel(III) intermediate. Strikingly different reactivity between nickel-aryl and nickel-alkyl complexes implies different rate-determining steps for C(sp3)–C(sp3) and C(sp2)–C(sp3) bond formation. Kinetic data benchmark the capture rates on the scale of 10[7] M?1s?1 and 10[6] M?1s?1 for primary and secondary radicals, respectively. Overall, the activation energy is higher than that of previous computational estimations. Finally, stoichiometric experiments with well-defined chiral nickel complexes demonstrate that the radical trapping step can confer diastereoselectivity and enantioselectivity with a drastic ligand effect.

Purchased from AmBeed: ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;

Product Details of [ 27060-75-9 ]

CAS No. :27060-75-9 MDL No. :MFCD00060687
Formula : C8H9BrO Boiling Point : No data available
Linear Structure Formula :- InChI Key :BLZNSXFQRKVFRP-UHFFFAOYSA-N
M.W : 201.06 Pubchem ID :117915
Synonyms :

Calculated chemistry of [ 27060-75-9 ]      Expand+

Physicochemical Properties

Num. heavy atoms : 10
Num. arom. heavy atoms : 6
Fraction Csp3 : 0.25
Num. rotatable bonds : 1
Num. H-bond acceptors : 1.0
Num. H-bond donors : 0.0
Molar Refractivity : 45.6
TPSA : 9.23 ?2

Pharmacokinetics

GI absorption : High
BBB permeant : Yes
P-gp substrate : No
CYP1A2 inhibitor : Yes
CYP2C19 inhibitor : No
CYP2C9 inhibitor : No
CYP2D6 inhibitor : No
CYP3A4 inhibitor : No
Log Kp (skin permeation) : -5.27 cm/s

Lipophilicity

Log Po/w (iLOGP) : 2.47
Log Po/w (XLOGP3) : 3.18
Log Po/w (WLOGP) : 2.77
Log Po/w (MLOGP) : 2.88
Log Po/w (SILICOS-IT) : 2.96
Consensus Log Po/w : 2.85

Druglikeness

Lipinski : 0.0
Ghose : None
Veber : 0.0
Egan : 0.0
Muegge : 1.0
Bioavailability Score : 0.55

Water Solubility

Log S (ESOL) : -3.47
Solubility : 0.0684 mg/ml ; 0.00034 mol/l
Class : Soluble
Log S (Ali) : -3.04
Solubility : 0.181 mg/ml ; 0.000902 mol/l
Class : Soluble
Log S (SILICOS-IT) : -3.77
Solubility : 0.0342 mg/ml ; 0.00017 mol/l
Class : Soluble

Medicinal Chemistry

PAINS : 0.0 alert
Brenk : 0.0 alert
Leadlikeness : 1.0
Synthetic accessibility : 1.18

Safety of [ 27060-75-9 ]

Signal Word:Warning Class:
Precautionary Statements:P261-P305+P351+P338 UN#:
Hazard Statements:H315-H319-H335 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 27060-75-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 27060-75-9 ]

[ 27060-75-9 ] Synthesis Path-Downstream   1~4

  • 1
  • [ 27060-75-9 ]
  • [ 557-21-1 ]
  • [ 21883-13-6 ]
  • 2
  • [ 27060-75-9 ]
  • [ 2338-54-7 ]
  • 3
  • [ 557-21-1 ]
  • [ 27060-75-9 ]
  • [ 21883-13-6 ]
  • 4
  • [ 27060-75-9 ]
  • [ 75-05-8 ]
  • [ 21883-13-6 ]
Recommend Products
Same Skeleton Products

Technical Information

Historical Records

Related Functional Groups of
[ 27060-75-9 ]

Aryls

Chemical Structure| 6267-34-1

[ 6267-34-1 ]

2-Bromo-5-methoxy-1,3-dimethylbenzene

Similarity: 0.95

Chemical Structure| 150192-39-5

[ 150192-39-5 ]

(2-Bromo-5-methoxyphenyl)methanol

Similarity: 0.95

Chemical Structure| 68155-69-1

[ 68155-69-1 ]

1-Bromo-4-ethoxy-2-methylbenzene

Similarity: 0.95

Chemical Structure| 31804-36-1

[ 31804-36-1 ]

1-Bromo-3-methoxy-2-methylbenzene

Similarity: 0.95

Chemical Structure| 14542-71-3

[ 14542-71-3 ]

3,5-Dibromo-4-methylanisole

Similarity: 0.93

Bromides

Chemical Structure| 6267-34-1

[ 6267-34-1 ]

2-Bromo-5-methoxy-1,3-dimethylbenzene

Similarity: 0.95

Chemical Structure| 150192-39-5

[ 150192-39-5 ]

(2-Bromo-5-methoxyphenyl)methanol

Similarity: 0.95

Chemical Structure| 68155-69-1

[ 68155-69-1 ]

1-Bromo-4-ethoxy-2-methylbenzene

Similarity: 0.95

Chemical Structure| 31804-36-1

[ 31804-36-1 ]

1-Bromo-3-methoxy-2-methylbenzene

Similarity: 0.95

Chemical Structure| 14542-71-3

[ 14542-71-3 ]

3,5-Dibromo-4-methylanisole

Similarity: 0.93

Ethers

Chemical Structure| 6267-34-1

[ 6267-34-1 ]

2-Bromo-5-methoxy-1,3-dimethylbenzene

Similarity: 0.95

Chemical Structure| 150192-39-5

[ 150192-39-5 ]

(2-Bromo-5-methoxyphenyl)methanol

Similarity: 0.95

Chemical Structure| 68155-69-1

[ 68155-69-1 ]

1-Bromo-4-ethoxy-2-methylbenzene

Similarity: 0.95

Chemical Structure| 31804-36-1

[ 31804-36-1 ]

1-Bromo-3-methoxy-2-methylbenzene

Similarity: 0.95

Chemical Structure| 14542-71-3

[ 14542-71-3 ]

3,5-Dibromo-4-methylanisole

Similarity: 0.93

; ;