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tert-butyl (S)-((1-(2-amino-3-fluoro-6-nitrophenyl)pyrrolidin-2-yl)methyl)carbamate[ No CAS ]
Yield
Reaction Conditions
Operation in experiment
37%
With triethylamine; In 2-methoxy-ethanol; at 120.0℃;
A mixture of <strong>[141774-70-1](S)-tert-butyl pyrrolidin-2-ylmethylcarbamate</strong> (2.4 g, 12.0 mmol), 2,6-difluoro-3-nitroaniline (2.0 g, 11.5 mmol), 2-methoxyethanol (15 mL), and triethylamine (3 mL, 21.5 mmol) was stirred at 120 C. overnight. The mixture was then cooled to r.t., diluted with water and extracted with CH2Cl2. The combined organic phases were dried over MgSO4, concentrated, and the crude product obtained was purified by Biotage Isolera to afford tert-butyl (S)-((1-(2-amino-3-fluoro-6-nitrophenyl)pyrrolidin-2-yl)methyl)carbamate (1.51 g, 37% yield) as an orange oil. LCMS calculated for C16H24FN4O4 (M+H)+: m/z=355.2; Found: 355.1.
37%
With triethylamine; In 2-methoxy-ethanol; at 120.0℃;
A mixture of <strong>[141774-70-1](S)-tert-butyl pyrrolidin-2-ylmethylcarbamate</strong> (2.4 g, 12.0 mmol), 2,6-difluoro-3-nitroaniline (2.0 g, 11.5 mmol), 2-methoxyethanol (15 mL), and triethylamine (3 mL, 21.5 mmol) was stirred at 120 C. overnight. The mixture was then cooled to r.t., diluted with water and extracted with CH2Cl2. The combined organic phases were dried over MgSO4, concentrated, and the crude product obtained was purified by Biotage Isolera to afford tert-butyl (S)-((1-(2-amino-3-fluoro-6-nitrophenyl)pyrrolidin-2-yl)methyl)carbamate (1.51 g, 37% yield) as an orange oil. LCMS calculated for C16H24FN4O4 (M+H)+: m/z=355.2; Found: 355.1.
Chemistry
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Material Science
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120K+ Compounds
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