天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

Home Cart 0 Sign in  

[ CAS No. 2576-47-8 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
Chemical Structure| 2576-47-8
Chemical Structure| 2576-47-8
Structure of 2576-47-8 * Storage: {[proInfo.prStorage]}

Please Login or Create an Account to: See VIP prices and availability

Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Search after Editing

* Storage: {[proInfo.prStorage]}

* Shipping: {[proInfo.prShipping]}

Quality Control of [ 2576-47-8 ]

Related Doc. of [ 2576-47-8 ]

Alternatived Products of [ 2576-47-8 ]
Product Citations

Product Details of [ 2576-47-8 ]

CAS No. :2576-47-8 MDL No. :MFCD00012886
Formula : C2H7Br2N Boiling Point : -
Linear Structure Formula :BrCH2CH2NH3Br InChI Key :WJAXXWSZNSFVNG-UHFFFAOYSA-N
M.W : 204.89 Pubchem ID :2774217
Synonyms :

Calculated chemistry of [ 2576-47-8 ]      Expand+

Physicochemical Properties

Num. heavy atoms : 5
Num. arom. heavy atoms : 0
Fraction Csp3 : 1.0
Num. rotatable bonds : 1
Num. H-bond acceptors : 1.0
Num. H-bond donors : 1.0
Molar Refractivity : 31.23
TPSA : 26.02 ?2

Pharmacokinetics

GI absorption : Low
BBB permeant : No
P-gp substrate : No
CYP1A2 inhibitor : No
CYP2C19 inhibitor : No
CYP2C9 inhibitor : No
CYP2D6 inhibitor : No
CYP3A4 inhibitor : No
Log Kp (skin permeation) : -6.83 cm/s

Lipophilicity

Log Po/w (iLOGP) : 0.0
Log Po/w (XLOGP3) : 1.02
Log Po/w (WLOGP) : -2.54
Log Po/w (MLOGP) : 1.16
Log Po/w (SILICOS-IT) : 0.28
Consensus Log Po/w : -0.02

Druglikeness

Lipinski : 0.0
Ghose : None
Veber : 0.0
Egan : 0.0
Muegge : 2.0
Bioavailability Score : 0.55

Water Solubility

Log S (ESOL) : -1.69
Solubility : 4.21 mg/ml ; 0.0206 mol/l
Class : Very soluble
Log S (Ali) : -1.16
Solubility : 14.3 mg/ml ; 0.0698 mol/l
Class : Very soluble
Log S (SILICOS-IT) : -1.14
Solubility : 14.9 mg/ml ; 0.0728 mol/l
Class : Soluble

Medicinal Chemistry

PAINS : 0.0 alert
Brenk : 1.0 alert
Leadlikeness : 1.0
Synthetic accessibility : 2.07

Safety of [ 2576-47-8 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 2576-47-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 2576-47-8 ]

[ 2576-47-8 ] Synthesis Path-Downstream   1~6

  • 1
  • [ 2576-47-8 ]
  • [ 926-39-6 ]
  • 3
  • [ 2576-47-8 ]
  • [ 65826-95-1 ]
  • [ 552866-97-4 ]
  • 4
  • [ 605-65-2 ]
  • [ 2576-47-8 ]
  • [ 606-25-7 ]
YieldReaction ConditionsOperation in experiment
86.1% With triethylamine; In tetrahydrofuran; EXAMPLE 11 Naphthalenesulfonamide, 5-(dimethylamino)-N-(2-bromoethyl) A suspension of 5-dimethylaminonaphthalene-1-sulfonyl chloride (50.0 g, 0.185 mol) and 2-bromoethylamine hydro-bromide (40.4 g, 0.197 mol) in THF (500 mL) was cooled to 2 C. A solution of triethylamine (38.5 g, 0.380 mol) in THF (250 mL) was added dropwise over a 2 h period while maintaining the internal temperature below 6 C. After complete addition the mixture was stirred at ambient temperature for 17 h. The mixture was clarified then concentrated to an orange oil which was chromatographed over silica (2.2 kg) packed and eluted with hexanes-EtOAc (3:1). Fractions (500 mL) containing the purified product were combined, clarified, then concentrated to a damp solid. This material was triturated in hexanes (250 mL), collected on a filter, washed with hexanes (50 mL) then dried to constant weight in vacuo at 40 C. to give 56.9 g (86.1% yield) of product as a off-white crystalline solid.
  • 5
  • [ 2576-47-8 ]
  • [ 98045-03-5 ]
  • [ 943443-99-0 ]
  • 6
  • [ 23094-96-4 ]
  • [ 2576-47-8 ]
  • C9H11Br2NO3S [ No CAS ]
YieldReaction ConditionsOperation in experiment
With triethylamine; In dichloromethane; at 0 - 20℃;Inert atmosphere; General procedure: To a solution of 2-bromoethylamine hydrobromide (for 12a-j) (1 equiv.) and 2.5 equiv. of triethylamine in dry DCM (5mL), 0.83 equiv. of commercially available arylsulfonyl chloride (11a-j) were added at 0C under nitrogen atmosphere. Then, the reaction mixture was stirred at room temperature until the complete conversion of the arylsulfonyl chloride as controlled by TLC. DCM was then added and the organic layer was washed with water and brine, dried over magnesium sulfate, filtered and concentrated under reduced pressure to provide the desired product used for the synth esis of compound 7 without further purification. Compound 13 was obtained using 1 equiv. of 3-bromopropylamine hydrobromide and 0.83 equiv. of 4-methoxybenzenesulfonyl chloride following the same general procedure used for compounds 12a-j.
Recommend Products
Same Skeleton Products

Technical Information

Historical Records

Related Functional Groups of
[ 2576-47-8 ]

Aliphatic Chain Hydrocarbons

Chemical Structure| 40052-63-9

[ 40052-63-9 ]

2-Bromo-N-methylethanamine hydrobromide

Similarity: 0.75

Chemical Structure| 43204-63-3

[ 43204-63-3 ]

Bis(2-Bromoethyl)amine hydrobromide

Similarity: 0.69

Chemical Structure| 2862-39-7

[ 2862-39-7 ]

2-Bromo-N,N-dimethylethanamine hydrobromide

Similarity: 0.64

Chemical Structure| 5003-71-4

[ 5003-71-4 ]

3-Bromopropan-1-amine hydrobromide

Similarity: 0.62

Chemical Structure| 683-57-8

[ 683-57-8 ]

2-Bromoacetamide

Similarity: 0.56

Bromides

Chemical Structure| 40052-63-9

[ 40052-63-9 ]

2-Bromo-N-methylethanamine hydrobromide

Similarity: 0.75

Chemical Structure| 43204-63-3

[ 43204-63-3 ]

Bis(2-Bromoethyl)amine hydrobromide

Similarity: 0.69

Chemical Structure| 2862-39-7

[ 2862-39-7 ]

2-Bromo-N,N-dimethylethanamine hydrobromide

Similarity: 0.64

Chemical Structure| 5003-71-4

[ 5003-71-4 ]

3-Bromopropan-1-amine hydrobromide

Similarity: 0.62

Chemical Structure| 683-57-8

[ 683-57-8 ]

2-Bromoacetamide

Similarity: 0.56

Amines

Chemical Structure| 40052-63-9

[ 40052-63-9 ]

2-Bromo-N-methylethanamine hydrobromide

Similarity: 0.75

Chemical Structure| 43204-63-3

[ 43204-63-3 ]

Bis(2-Bromoethyl)amine hydrobromide

Similarity: 0.69

Chemical Structure| 2862-39-7

[ 2862-39-7 ]

2-Bromo-N,N-dimethylethanamine hydrobromide

Similarity: 0.64

Chemical Structure| 5003-71-4

[ 5003-71-4 ]

3-Bromopropan-1-amine hydrobromide

Similarity: 0.62

Chemical Structure| 683-57-8

[ 683-57-8 ]

2-Bromoacetamide

Similarity: 0.56

; ;