[ CAS No. 24677-78-9 ] {[proInfo.proName]}

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2D 3D

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Quality Control of [ 24677-78-9 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 24677-78-9 ]

SDS Specification

Alternatived Products of [ 24677-78-9 ]

Product Details of [ 24677-78-9 ]

CAS No. :	24677-78-9	MDL No. :	MFCD00003324
Formula :	C₇H₆O₃	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	IXWOUPGDGMCKGT-UHFFFAOYSA-N
M.W :	138.12	Pubchem ID :	90579
Synonyms :

Calculated chemistry of [ 24677-78-9 ] Expand+

Physicochemical Properties

Num. heavy atoms :	10
Num. arom. heavy atoms :	6
Fraction Csp3 :	0.0
Num. rotatable bonds :	1
Num. H-bond acceptors :	3.0
Num. H-bond donors :	2.0
Molar Refractivity :	35.88
TPSA :	57.53 ?2

Pharmacokinetics

GI absorption :	High
BBB permeant :	Yes
P-gp substrate :	No
CYP1A2 inhibitor :	No
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	Yes
Log Kp (skin permeation) :	-6.11 cm/s

Lipophilicity

Log Po/w (iLOGP) :	0.94
Log Po/w (XLOGP3) :	1.45
Log Po/w (WLOGP) :	0.91
Log Po/w (MLOGP) :	0.18
Log Po/w (SILICOS-IT) :	1.02
Consensus Log Po/w :	0.9

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	1.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	-1.99
Solubility :	1.42 mg/ml ; 0.0103 mol/l
Class :	Very soluble
Log S (Ali) :	-2.26
Solubility :	0.752 mg/ml ; 0.00545 mol/l
Class :	Soluble
Log S (SILICOS-IT) :	-1.17
Solubility :	9.4 mg/ml ; 0.0681 mol/l
Class :	Soluble

Medicinal Chemistry

PAINS :	1.0 alert
Brenk :	2.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	1.0

Safety of [ 24677-78-9 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P305+P351+P338	UN#:	N/A
Hazard Statements:	H302-H315-H319-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 24677-78-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 24677-78-9 ]
Downstream synthetic route of [ 24677-78-9 ]

[ 24677-78-9 ] Synthesis Path-Upstream 1~1

1
[ 24677-78-9 ]
[ 5768-39-8 ]

Reference： [1] Agricultural and Biological Chemistry, 1980, vol. 44, # 2, p. 235 - 243

[ 24677-78-9 ] Synthesis Path-Downstream 1~10

1
[ 24677-78-9 ]
[ 74-88-4 ]
[ 66495-88-3 ]

Yield	Reaction Conditions	Operation in experiment
88.8%		Reference example 9-1 Preparation for 3-hydroxy-2-methoxybenzaldehyde To a solution of 2,3-hydroxybenzaldehyde (200mg, 1.45mmol) in N,N-dimethylformamide (3.0ml) was added sodium hydride (60.8mg, 1.52mmol) at room temperature, and the mixture was stirred for 1 hour at 50C. The reaction mixture was cooled to room temperature and thereto was added methyl iodide (226mg, 1.60mmol).. The mixture was stirred for 1 hour at 40C and allowed to cool to room temperature, followed by addition of water and extracted with ethyl acetate-toluene (3:1).. The organic layer was washed with water and an aqueous saturated sodium chloride solution in the order, and dried over anhydrous magnesium sulfate.. The solvent was removed under reduced pressure and the residue was recrystallized from hexane to give the subject compound (196mg, 88.8%).1H NMR (CDCl3, 400 MHz) δ 10.27 (s, 1 H), 7.37 (dd, 1 H, J = 1.7 and 7.7 Hz), 7.23 (dd, 1 H, J = 1.7 and 8.0 Hz), 7.15 (m, 1 H), 5.82 (s, 1 H), 3.98 (s, 3 H).. Reference example 9-2
73%	With potassium carbonate; In N,N-dimethyl-formamide; at 20℃; for 12h;Inert atmosphere;	General procedure: To a suspension of substituted 2- or 3-hydroxybenzaldehydes (15, 21, 24, and 27) (1 mmol,1.0 equiv) and K2CO3 (1 mmol, 1 equiv) in anhydrousDMF (6 mL) was added methyl iodide (0.06 mL, 1.0 mmol,1.0 equiv) dropwise under nitrogen atmosphere at room temperature.The mixture was stirred for overnight at room temperature.After completion of the reaction, water (10 mL)was added. The mixture was then extracted with ether(2 × 25 mL), the combined organic layer was washed withbrine (2 × 30 mL), dried over anhydrous Na2SO4, filteredand the filtrate was concentrated in vacuo. The crude residuewas purified by column chromatography (EtOAc/hexane = 1/4) to yield substituted 2- or 3-methoxy benzaldehyde (23, 22,25, and 8) [in case of compound 24, 1.5 equiv of K2CO3 and1.5 equiv of methyl iodide employed].
73%		To a stirred solution of 2,3-dihydroxybenzaldehyde (1.00 g, 7.24 mmol) in anhydrous DMF (20 mL) was added K2CO3 (1.00 g, 7.24 mmol) and the mixture was stirred at room temperature for 30 minutes. CH3I (0.54 mL, 8.68 mmol) was then slowly added to the mixture and stirred for 8 hours. After completion of the reaction, it was neutralized by addition of 1N HCl and extracted with ether (3 x 30 mL). The combined organic solvent layers were washed with water (3 x 40 mL), brine (3 x 40 mL), dried over anhydrous Na2SO4 and concentrated in vacuo. The crude was purified by column chromatography (EtOAc: Hexane = 1: 4) To give a white solid compound 10 (0.80 g, 73%).

73%		To a stirred solution of 2,3-dihydroxybenzaldehyde (1.00 g, 7.24 mmol) in anhydrous DMF (20 mL) was added K2CO3 (1.00 g, 7.24 mmol) and the mixture was stirred at room temperature for 30 minutes. CH3I (0.54 mL, 8.68 mmol) was then slowly added to the mixture and stirred for 8 hours.After completion of the reaction, it was neutralized with 1N HCl and extracted with ether (3 x 30 mL).The combined organic solvent layers were washed with water (3 x 40 mL), brine (3 x 40 mL), dried over anhydrous Na2SO4 and concentrated in vacuo.The crude compound was purified by column chromatography (EtOAc: Hexane = 1: 4) to give a white solid compound 10 (0.80 g, 73%).
62%		A solution of 2, 3-dihydroxybenzaldehyde (10 g, 72 [MMOL)] in anhydrous DMF (100 mL) was treated with K2CO3 (10 g, 72 [MMOL)] at [25C] and the mixture was stirred for 30 minutes. [LODOMETHANE] (4.9 mL, 80 [MMOL)] was added and the reaction was further stirred for 20 h. The reaction was quenched with water and extracted with diethyl ether. The organic layer was dried using sodium sulfate and solvents were evaporated under vacuum. The residue was purified by Biotage to obtain 3-hydroxy-2- [METHOXYBENZALDEHYDE] (6.8 g, 45 mmol, 62%) as a white [SOLID.'H] NMR [(CDC ! S) 5] 4.0 (s, 3H), 5.9 (s, [1H),] 7.2 (m, 2H), 7.4 (m, 1H), 10.3 (s, [1H)] ; GC/MS (ES) 153 [(M+1) +.]
57%		A solution of 2,3-dihydroxybenzaldehyde (1.0 g, 7.24 mmol) in DMF (10 mL) was treated with K2CO3 (1.0 g, 7.24 mmol) and the mixture was stirred at rt for 30 min. Iodomethane (0.50 ml, 7.96 mmol) was added and the reaction was further stirred for 20 h. The reaction was quenched with H2O and extracted with Et2O. The organic layer was dried over Na2SO4 and concentrated. The residue was purified flash column chromatography to afford the title compound (0.63 g, 57%) as a colorless needle.1H NMR δ (CDCl3) 10.28 (1H, s), 7.39 (1H, dd, J=7.8 Hz, 1.8 Hz), 7.25 (1H, dd, J=7.8 Hz, 1.8 Hz), 7.17 (1H, t, J=7.8 Hz), 5.81 (1H, s), 3.99 (1H, s)ESI-MS [M+H]+: 153
45%	With potassium carbonate; In N,N-dimethyl-formamide; at 20℃; for 18h;	General procedure: The compound of Formula (VI) is synthesized as shown in the following scheme:
40%	With potassium carbonate; In N,N-dimethyl-formamide; at 20℃; for 20h;	Reference Example 52 3-hydroxy-2-methoxybenzaldehyde; [Show Image] To a solution (80 mL) of 2,3-dihydroxybenzaldehyde (5.00 g) in N,N-dimethylformamide were added potassium carbonate (4.93 g) and a solution (20 mL) of iodomethane (6.89 g) in N,N-dimethylformamide, and the mixture was stirred at room temperature for 20 hr. Water was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine, dried over anhydrous magnesium sulfate, and filtered, and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: hexane-ethyl acetate=100:0→60:40) to give the title compound as a white solid (yield: 2.16 g, 40%). 1H-NMR (CDCl3, 300 MHz):δ3.98 (3H, s), 5.83 (1H, s), 7.15 (1H, dd, J = 8 . 1, 7.7 Hz), 7 . 24 (1H, dd, J = 8.1, 1.8 Hz), 7.38 (1H, dd, J = 7.6, 1.8 Hz), 10.27 (1H, s).
		[0308] 2,3-dihydroxybenzaldehyde (27.6 g) (200 mmol) is mixed with dry DMF (460 mL) and KHCO3 (80 g, 800 mmol), under N2 atmosphere. The mixture is stirred at room temperature for 30 min. MeI (51 mL, 820 mmol) is added in one portion. The mixture is further stirred at room temperature for 30 h. The excess MeI is evaporated in vacuo. H2O (1.1 L) is added, followed by 37% HCl (46 mL) to reach pH ~3.5 after the addition. The mixture is extracted with Et2O (4x0.55 L then 1x0.28 L). The combined organic layer is further washed with saturated NH4Cl (2x0.35 L), then brine (1x0.7 L), dried on MgSO4, filtered and evaporated in vacuo to yield the crude desired product. This crude is dissolved in Et2O (0.7 L), and extracted with 1M NaOH (2x0.42 L). The combined aqueous layer is treated with 37% HCl (71 mL) to reach pH ~ 1. The resulting suspension is cooled to 15C, filtered on a Buchner filter, the solid is washed with H2O (2x30 mL), dried under suction and then in vacuo at 42C to yield the desired product.

Reference： [1]Journal of the American Chemical Society,1999,vol. 121,p. 2471 - 2477
[2]Patent: EP1386913,2004,A1 .Location in patent: Page 57
[3]Bulletin of the Korean Chemical Society,2015,vol. 36,p. 2907 - 2914
[4]Patent: KR101747693,2017,B1 .Location in patent: Paragraph 0016-0017
[5]Patent: KR101747694,2017,B1 .Location in patent: Paragraph 0016; 0017
[6]Tetrahedron,2007,vol. 63,p. 12379 - 12387
[7]Molecules,2017,vol. 22
[8]Patent: WO2004/11446,2004,A1 .Location in patent: Page 63
[9]European Journal of Organic Chemistry,2014,vol. 2014,p. 2565 - 2575
[10]Patent: US2011/136801,2011,A1 .Location in patent: Page/Page column 52
[11]Journal of Natural Products,1998,vol. 61,p. 1263 - 1267
[12]Patent: WO2021/107876,2021,A1 .Location in patent: Paragraph 112-113
[13]Patent: EP2450352,2012,A1 .Location in patent: Page/Page column 79
[14]Chemical and Pharmaceutical Bulletin,1986,vol. 34,p. 2024 - 2036
[15]Synthesis,2004,p. 1664 - 1670
[16]Organic and biomolecular chemistry,2003,vol. 1,p. 908 - 920
[17]Patent: WO2004/46162,2004,A2 .Location in patent: Page 6; 7; Sheet 5
[18]Journal of Organic Chemistry,2011,vol. 76,p. 6475 - 6487
[19]Synthetic Communications,2012,vol. 42,p. 292 - 298
[20]Patent: WO2016/169911,2016,A1 .Location in patent: Paragraph 0308

2
[ 24677-78-9 ]
[ 66495-88-3 ]

Yield	Reaction Conditions	Operation in experiment
		EXAMPLE 21 Isopropyl 2-butyl-3-[4-[3-(dibutylamino)propyl]-benzoyl]-1-benzofuran-7-carboxylate Oxalate [0370] A. 3-Hydroxy-2-methoxybenzaldehyde [0371] 13.08 g (0.39 mol) of sodium hydride are introduced into 300 ml of dimethyl sulphoxide and then 54 g (0.39 mol) of 2,3-dihydroxybenzaldehyde are added. The reaction medium is maintained at ambient temperature for 1 hour and then 55.35 g (26.3 ml, 0.39 mol) of methyl iodide in 60 ml of dimethyl sulphoxide are added dropwise. The mixture is maintained at ambient temperature for 18 hours and then is diluted with water. Hydrochloric acid is added, extraction is carried out with ethyl acetate and the extract is washed with an aqueous sodium chloride solution. Purification is subsequently carried out by chromatography on silica (eluent: 97/3 dichloromethane/ethyl acetate). [0372] In this way, 27.69 g of the desired product are obtained. [0373] M.p.: 116 C.

Reference： [1]Patent: US2003/225100,2003,A1 .Location in patent: Page 20
[2]Patent: WO2020/148354,2020,A1

3
[ 24677-78-9 ]
[ 67984-81-0 ]

Reference： [1]Chemical and Pharmaceutical Bulletin,2010,vol. 58,p. 1552 - 1553

4
[ 24677-78-9 ]
[ 68176-57-8 ]
C₂₄H₂₄N₂O₄ [ No CAS ]

Reference： [1]Dalton Transactions,2013,vol. 42,p. 1427 - 1436

5
[ 24677-78-9 ]
[ 4442-53-9 ]

Reference： [1]Patent: WO2013/153535,2013,A1

6
[ 6964-21-2 ]
[ 24677-78-9 ]
[ 108-24-7 ]
8-acetoxy-3-(thiophen-3′-yl)coumarin [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
79%	With potassium acetate; for 16h;Reflux; Inert atmosphere;	General procedure: Compounds were synthesized under anhydrous conditions, using a material previously dried at 60 C for at least 12 h and at 300 C for a few minutes immediately before use. A solution containing anhydrous CH3CO2K (2.94 mmol), the corresponding thiophenylacetic acid (1.67 mmol) and the corresponding hydroxysalicylaldehyde (1.67 mmol), in Ac2O (1.2 mL), was refluxed for 16 h. The reaction mixture was cooled, neutralized with 10% aqueous NaHCO3, and extracted with EtOAc (3 × 30 mL). The organic layers were combined, washed with water, dried over anhydrous Na2SO4 and the solvent was evaporated under reduced pressure. The product was purified by recrystallization in EtOH and dried in vacuum to afford the desired compound [26,27].

Reference： [1]MedChemComm,2016,vol. 7,p. 845 - 852
[2]Bioorganic Chemistry,2020,vol. 101

7
[ 24677-78-9 ]
[ 770-05-8 ]
C₁₅H₁₅NO₄ [ No CAS ]

Reference： [1]Photochemical and Photobiological Sciences,2018,vol. 17,p. 442 - 452

8
[ 24677-78-9 ]
[ 13612-34-5 ]
8-hydroxy-3-(2,5-dimethylphenyl)-coumarin [ No CAS ]

Reference： [1]Journal of Enzyme Inhibition and Medicinal Chemistry,2019,vol. 34,p. 15 - 30

9
[ 24677-78-9 ]
[ 41764-74-3 ]
(E)-N'-(2,3-dihydroxybenzylidene)-3,4-dimethoxybenzohydrazide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
32%	In ethanol; for 6h;Reflux;	General procedure: A mixture of methyl 3,4-dimethoxybenzoate (1mmol) and corresponding benzaldehyde (1mmol) was refluxed in ethanol (7ml) for 6h. Reaction completion was checked by TLC. The mixture was cooled to room temperature and the resulted precipitate was collected and washed with diethyl ether to yield the final pure products. Moreover, in some cases, recrystallization in appropriate solvents was done in order to obtain the pure derivatives. 2.4.1 (E)-3,4-dimethoxy-N'-(4-nitrobenzylidene)benzohydrazide (D1) Yellow solid; yield: 82%; M.P: 208-210C. 1H NMR (300MHz, DMSO-d6): δ (ppm) 3.85 (s, 6H, OCH3), 7.09 (d, 1H, Ar-H-5, J=6.5Hz), 7.42-7.58 (m, 2H, Ar-H-2, 6), 7.96 (d, 2H, Ar-H-2′,6′), 8.28 (d, 2H, Ar-H-3′,5′), 8.55 (s, 1H, N=CH), 12.00 (s, 1H, NH). 13C NMR (75MHz, DMSO-d6): δ (ppm) 56.10 (OCH3), 56.14 (OCH3), 111.46, 121.66, 121.70, 124.52, 125.53, 128.32, 141.26, 145.06, 148.20, 148.86, 152.45, 163.24 (C=O). MS (EI, 70eV): m/z (%)=329 (M+, 10), 165 (100). Anal. Calcd for C16H15N3O5: C 58.36, H 4.59, N 12.76%, found: C 58.44, H 4.61, N 12.72%.

Reference： [1]Bioorganic and Medicinal Chemistry,2019,vol. 27,p. 2644 - 2651

10
[ 7504-94-1 ]
[ 24677-78-9 ]
(E)-3-((2-(pyrimidin-2-yl)hydrazono)methyl)benzene-1,2-diol [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
47%	In ethanol; at 20℃;	General procedure: Compounds 2 were prepared by the reaction between <strong>[7504-94-1]2-hydrazinylpyrimidine</strong> 1 (0.04 g, 0.36 mmol) and the appropriate aromatic or heteroaromatic aldehyde (1.0 eq., 0.36 mmol) in ethanol (3.0 mL) [27]. The reaction mixture was stirred for between 20 min and 5 h at room temperature. After rotary evaporation, the product was purified by washing with cold ethanol (2.0 mL) and cold diethyl ether (2.0 mL), leading to the pure derivatives 2a-f as solid in 27-75% yields.

Reference： [1]European Journal of Medicinal Chemistry,2019,vol. 184

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Technical Information

? Acidity of Phenols ? Barbier Coupling Reaction ? Baylis-Hillman Reaction ? Benzylic Oxidation ? Birch Reduction ? Blanc Chloromethylation ? Bucherer-Bergs Reaction ? Chan-Lam Coupling Reaction ? Clemmensen Reduction ? Complex Metal Hydride Reductions ? Corey-Chaykovsky Reaction ? Corey-Fuchs Reaction ? Electrophilic Substitution of the Phenol Aromatic Ring ? Etherification Reaction of Phenolic Hydroxyl Group ? Fischer Indole Synthesis ? Friedel-Crafts Reaction ? Grignard Reaction ? Halogenation of Phenols ? Hantzsch Dihydropyridine Synthesis ? Henry Nitroaldol Reaction ? Horner-Wadsworth-Emmons Reaction ? Hydride Reductions ? Hydrogenolysis of Benzyl Ether ? Julia-Kocienski Olefination ? Knoevenagel Condensation ? Leuckart-Wallach Reaction ? McMurry Coupling ? Meerwein-Ponndorf-Verley Reduction ? Mukaiyama Aldol Reaction ? Nozaki-Hiyama-Kishi Reaction ? Oxidation of Phenols ? Passerini Reaction ? Paternò-Büchi Reaction ? Pechmann Coumarin Synthesis ? Petasis Reaction ? Pictet-Spengler Tetrahydroisoquinoline Synthesis ? Preparation of Aldehydes and Ketones ? Preparation of Alkylbenzene ? Preparation of Amines ? Prins Reaction ? Reactions of Aldehydes and Ketones ? Reactions of Amines ? Reactions of Benzene and Substituted Benzenes ? Reformatsky Reaction ? Reimer-Tiemann Reaction ? Schlosser Modification of the Wittig Reaction ? Schmidt Reaction ? Stetter Reaction ? Stobbe Condensation ? Tebbe Olefination ? Ugi Reaction ? Vilsmeier-Haack Reaction ? Wittig Reaction ? Wolff-Kishner Reduction

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P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

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[ CAS No. 24677-78-9 ] {[proInfo.proName]}

Quality Control of [ 24677-78-9 ]

Related Doc. of [ 24677-78-9 ]

Product Details of [ 24677-78-9 ]

Calculated chemistry of [ 24677-78-9 ] Expand+

Physicochemical Properties

Pharmacokinetics

Lipophilicity

Druglikeness

Water Solubility

Medicinal Chemistry

Safety of [ 24677-78-9 ]

Application In Synthesis of [ 24677-78-9 ]

[ 24677-78-9 ] Synthesis Path-Upstream 1~1

[ 24677-78-9 ] Synthesis Path-Downstream 1~10

Technical Information

Related Functional Groups of [ 24677-78-9 ]

Aryls

Aldehydes

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

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[ 24677-78-9 ]