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With potassium carbonate; In N,N-dimethyl-formamide; at 135℃; for 12h;
To a solution of 2-chloro-4-fluoro-l-iodo-benzene (3.6 g, 14.3 mmol) and 3-trifluoromethyl-lH-pyrazole (1.9 g, 14.4 mmol) in N,N-dimethylformamide (40 mL) was added potassium carbonate (2.4 g, 17.2 mmol), and the resulting mixture was heated at 135 C for 12 h. The reaction mixture was cooled to room temperature, poured in cold water (80 mL) and extracted with dichloromethane (2 x 40 mL). The combined organic extracts were dried (Na2S04) and concentrated under reduced pressure. The residue was purified by flash column chromatography on silica gel eluted with 10% ethyl acetate in hexanes to afford the title compound (4.2 g) as a white solid. lH NMR delta 10.4 (s, 1H), 7.88 (m, 2H), 7.80 (d, 1H), 7.27 (m, 1H), 6.68 (d, 1H). MS (AP+) 373 amu.
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