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With lithium hydroxide In tetrahydrofuran; water at 0 - 20℃;
To a 250 mL multi-vial was added 8.1g (30.8 mmol) Pyrrolidine-1,3-dicarboxylic acid-1-carbostyrene-3-methyl ester and80 mL of tetrahydrofuran,A drop of 3.9 g (92.4 mmo 1)Lithium hydroxide in 80 mL aqueous solution,0 ° C stirring lh,After stirring at room temperature overnight, the reaction was completed and the mixture was washed with ether,And 0.5M hydrochloric acid was added to adjust the pH of the mixture to 5 to 6 minutesThe mixture was extracted three times with 30 mL of ethyl acetate and the organic phases were combined. The organic phase was dried over anhydrous sodium sulfate, filtered, filteredThe solution was concentrated under reduced pressure to obtain 7.3 g of pyrrolidine-1,3-dicarboxylic acid-1-benzyl as a yellow oil in a yield of 95percent
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