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Type | HazMat fee for 500 gram (Estimated) |
Excepted Quantity | USD 0.00 |
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CAS No. : | 18362-64-6 | MDL No. : | MFCD00015040 |
Formula : | C9H16O2 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | CEGGECULKVTYMM-UHFFFAOYSA-N |
M.W : | 156.22 | Pubchem ID : | 87597 |
Synonyms : |
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Signal Word: | Danger | Class: | 3 |
Precautionary Statements: | P261-P305+P351+P338 | UN#: | 1224 |
Hazard Statements: | H225-H315-H319-H335 | Packing Group: | Ⅲ |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
77.3%Chromat. | With potassium tert-butylate; In DMF (N,N-dimethyl-formamide); at 50℃; for 11h;Heating / reflux; | In a 1-liter four-necked flask, 103 g of DMF and 1.33mol (149 g) of tert-butoxypotassium were placed, and theywere heated up to 50C with stirring by a mechanicalstirrer. Then, a liquid mixture consisting of 2.64 mol(307 g) of ethyl isobutyrate and 0.88 mol (75.6 g) of 3-methyl-2-butanone, was added by a dropping funnel over aperiod of 3 hours, followed by further stirring for 8hours under heating. It was confirmed by gaschromatography that 2,6-dimethyl-3,5-heptanedione was produced in an amount of 0.68 mol (107 g) in the solution(yield: 77.3% (based on 3-methylbutanone)). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
100% | With hydrazine; In ethanol; at 20℃; for 2h; | Hydrazine (330 mg, 10 mmol) was added to a solution of 2,6-dimethylheptane-3,5- dione (1.6 g, 10 mmol) in ethanol (40 mL) at room temperature. After 2 hours, the reaction was concentrated in vacuo to afford 3, 5-diisopropyl-lH-pyrazole (1.5 g, 10 mmol, yield: 100%) which was used in the next step without further purification. MS: m/z 153.1 (M+H+). |