* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Reference：
[1] Journal of the American Chemical Society, 1952, vol. 74, p. 1580,1582
[2] Journal of the American Chemical Society, 1949, vol. 71, p. 78,79, 80
EXAMPLE 10 2-Ethylsulfanyl-3-(5-fluoro-2-methylphenyl)-3,5-dihydro-imidazol-4-one A mixture of glycinamide hydrochloride (4.42 g), 5-fluoro-2-methylphenyl-isothiocyanate (6.68 g), triethyl amine (4.1 g), and chloroform (150 mL) was stirred at ambient temperature for 18 hours. The precipitate was collected by filtration, washed with chloroform and air dried to give 2-[3-(5-Fluoro-2-methylphenyl)-thioureido]-acetamide (7.6 g), m.p. 172-174 C. (dec.). This compound was used without further purification in the next paragraph.
With triethylamine; In chloroform;
EXAMPLE 10 2-Ethylsulfanyl-3-(5-fluoro-2-methylphenyl)-3,5-dihydroimidazol-4-one A mixture of glycinamide hydrochloride (4.42 g), 5-fluoro-2-methylphenylisothiocyanate (6.68 g), triethyl amine (4.1 g), and chloroform (150 mL) was stirred at ambient temperature for 18 hours. The precipitate was collected by filtration, washed with chloroform and air dried to give 2-[3-(5-Fluoro-2-methylphenyl)-thioureido]acetamide (7.6 g), m.p. 172-174 C. (dec.). This compound was used without further purification in the next paragraph.
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