* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
General procedure: 4 mL of acetonitrile in a 25 mL round bottom flask, then bromomethylphenylboronic acid (150 mg, 0.70 mmol) in 4 mL of acetonitrilewas injected and refluxed overnight at 80 C. The solution was dark redand the crude product was purified by column chromatography elutingwith dichloromethane: methanol (20:1, v/v) and a khaki solid wasobtained.4b
15 g
In toluene;Inert atmosphere; Reflux;
Add 100ml of dry toluene to the single-necked flask,9.07 g of 2,3,3-dimethyl-trihydroindole and 13.5 g of 3-bromomethylphenylboronic acid, under a nitrogen atmosphere, react at reflux overnight, and after cooling to room temperature,Filtration gave a fuchsia solid,Ethyl acetate washes away impurities,15g after drying3-bromomethylphenylboronic acid indole quaternary ammonium salt,The yield was 89.44% and the purity was 97.33%.