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With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate monohydrate; palladium diacetate; In toluene; at 100℃; for 15h;
To a stirred solution of <strong>[16932-45-9]2-bromo-1,3-dimethoxybenzene</strong> (0.50 g, 2.3 mmol) in toluene (23 mL) was added n-hexyl boronic acid (0.45g, 3.46 mmol, 3 eq.), K3PO4·H2O (1.06 g, 4.61 mmol, 2 eq.), palladium(II) acetate (52 mg, 0.23 mmol, 0.1 eq.) and dicyclohexyl-(2',6'-dimethoxy-biphenyl-2-yl)-phosphane (0.19 g, 0.46 mmol, 0.2 eq.) at room temperature. The mixture was strirred at 100C for 15h. After cooling to room temperature it was quenched with saturated aqueous NH4Cl solution and extracted with ethyl acetate. The organic layers were separated, washed (saturated aqueous NaCl solution), dried (MgSO4) and concentrated. Flash chromatography of the residue (silica, n-heptane / ethyl acetate 100:0 to 70:30) yielded 0.355 g (70%) of 31 as an oil.
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