Alternatived Products of [ 149793-69-1 ]
Product Details of [ 149793-69-1 ]
| CAS No. : | 149793-69-1 |
MDL No. : | MFCD00061282 |
| Formula : |
C8H3F4N
|
Boiling Point : |
- |
| Linear Structure Formula : | - |
InChI Key : | AYNUKEDZAYOEGG-UHFFFAOYSA-N |
| M.W : |
189.11
|
Pubchem ID : | 519037 |
| Synonyms : |
|
Safety of [ 149793-69-1 ]
| Signal Word: | Warning |
Class: | N/A |
| Precautionary Statements: | P280-P305+P351+P338 |
UN#: | N/A |
| Hazard Statements: | H302 |
Packing Group: | N/A |
| GHS Pictogram: |
|
Application In Synthesis of [ 149793-69-1 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Upstream synthesis route of [ 149793-69-1 ]
- Downstream synthetic route of [ 149793-69-1 ]
- 1
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[ 149793-69-1 ]
-
[ 6921-34-2 ]
-
[ 175205-81-9 ]
-
[ 939426-21-8 ]
| Yield | Reaction Conditions | Operation in experiment |
| 66.6% |
|
To an oven-dried round bottomed flask was added nBuLi (2.5 M in hexanes, 0.95 ml, 2.38 mmol, 1.17 eq) at -60° C. under N2. An Et2O solution (5 mL) of <strong>[175205-81-9]2-bromo-4-trifluoromethylpyridine</strong> (448 mg, 2.0 mmol) was added dropwise at -60 to -55° C. The resulting solution was stirred at the above temperate for 30 min. The mixture was cooled to -78° C., an Et2O solution (2 mL) of 3-fluoro-5-trifluoromethyl-benzonitrile (390 g, 2.06 mmol) was added dropwise. The resulting solution was stirred -78 to -70° C. for 1.5 h. Pretreated TMSCl (0.26 ml) was added dropwise at -78° C. The mixture was stirred at -78° C. for 15 min, and then warmed up to r.t. for 45 min. It was cooled back to -78° C., and benzyl magnesium chloride (1.0 ml, 2.0 mmol) was added dropwise. The resulting mixture was stirred at -78° C. for 1 h, and then at r.t. for 0.5 h. It was quenched by adding sat'd NH4Cl and 1N HCl, and stirred for 10 min. It was extracted with EtOAc, washed with 1N NaOH, sat'd NaHCO3, H2O, brine, dried (MgSO4), filtered, and concentrated to dryness. The residue was purified by flash chromatography (silica gel, hexanes/EtOAc) to give 1-(3-fluoro-5-(trifluoromethyl)phenyl)-2-phenyl-1-(4-(trifluoromethyl)pyridin-2-yl)ethanamine as light brownish gum (0.57 g, yield: 66.6percent). LC-MS ESI (10-90percent MeOH in H2O with 0.1percent TFA in a 4-min run), retention time=3.32 min, 429.13 (M+H). |
- 2
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[ 75-77-4 ]
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[ 149793-69-1 ]
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[ 175205-81-9 ]
-
C17H15F7N2Si
[ No CAS ]
| Yield | Reaction Conditions | Operation in experiment |
|
|
General procedure: Aryl or heteroaryl bromide (4 mmol) was charged in oven dried Radley's synthesis tube that was equipped with a stir bar under a stream of nitrogen. Anhydrous diethyl ether was added and the reaction mixture was cooled to -78 °C. n-BuLi (1.6 M in hexanes, 2.5 mL, 4.00 mmol) was added dropwise and the reaction mixture was stirred at -78 °C for 10 min. A solution of aryl or heteroaryl nitrile in THF (4 mmol) was added dropwise and the reaction mixture was stirred at -78 °C for 2 h. TMSCl (0.550 mL, 4.00 mmol) was added to the reaction mixture at -78 °C and the reaction mixture was allowed to warm up to 0 °C. The reaction mixture was cooled to -78 °C, benzylmagnesium chloride in either THF or ether (2 mmol) or benzyl zinc(II) bromide in ether (2 mmol), was added dropwise, stirred at -78 °C for 2 h, and then stirred at rt for 12 h. The reaction mixture was worked up and purified as in general procedure 1. |
- 3
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[ 149793-69-1 ]
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[ 175205-81-9 ]
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[ 939426-21-8 ]
- 4
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[ 130723-13-6 ]
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[ 149793-69-1 ]
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1-{1,1-bis[3-fluoro-5-(trifluoromethyl)phenyl]-2-phenylethyl}-3-cyclopentylurea
[ No CAS ]
- 5
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[ 130723-13-6 ]
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[ 149793-69-1 ]
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benzylmagnesium halide
[ No CAS ]
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C22H15F8N
[ No CAS ]
- 6
-
[ 149793-69-1 ]
-
[ 161622-05-5 ]
| Yield | Reaction Conditions | Operation in experiment |
| 8 g |
With sodium hydroxide; In water; at 85 - 90℃; for 2h; |
Example-16: Preparation of 3-fluoro-5-(trifluoromethyl)benzoic acid : In 100 ml four necked round bottom flask equipped with mechanical stirrer, thermometer, reflux condenser and an addition funnel, sodium hydroxide (6.35 g) and water (10 ml) was added and stirred for 15 mins at 25-35C. To this, 3-fluoro-5- (trifluoromethyl)benzonitrile (10 g) was added and heated to 85-90C. The reaction mass was stirred at 85-90C for 2 hrs. After completion of reaction, the reaction mass was allowed to cool to 25-35C. Then, the reaction mass was acidified with aqueous hydrochloric acid and stirred for 30 mins at 25-35C. The solid formed was filtered, washed with water, suck dried and then dried under vacuum at 50-55C for 6 hrs to get the title compound. Yield: 8 g. |
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