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[ CAS No. 147127-20-6 ] {[proInfo.proName]}

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Type HazMat fee for 500 gram (Estimated)
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Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
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Chemical Structure| 147127-20-6
Chemical Structure| 147127-20-6
Structure of 147127-20-6 * Storage: {[proInfo.prStorage]}

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Product Details of [ 147127-20-6 ]

CAS No. :147127-20-6 MDL No. :MFCD00943794
Formula : C9H14N5O4P Boiling Point : -
Linear Structure Formula :- InChI Key :SGOIRFVFHAKUTI-ZCFIWIBFSA-N
M.W : 287.21 Pubchem ID :464205
Synonyms :
GS 1278;PMPA;TDF;(R)-PMPA;GS-1275
Chemical Name :(R)-(((1-(6-Amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonic acid

Calculated chemistry of [ 147127-20-6 ]      Expand+

Physicochemical Properties

Num. heavy atoms : 19
Num. arom. heavy atoms : 9
Fraction Csp3 : 0.44
Num. rotatable bonds : 5
Num. H-bond acceptors : 7.0
Num. H-bond donors : 3.0
Molar Refractivity : 67.48
TPSA : 146.19 ?2

Pharmacokinetics

GI absorption : Low
BBB permeant : No
P-gp substrate : No
CYP1A2 inhibitor : No
CYP2C19 inhibitor : No
CYP2C9 inhibitor : No
CYP2D6 inhibitor : No
CYP3A4 inhibitor : No
Log Kp (skin permeation) : -9.19 cm/s

Lipophilicity

Log Po/w (iLOGP) : 0.41
Log Po/w (XLOGP3) : -1.6
Log Po/w (WLOGP) : -0.04
Log Po/w (MLOGP) : -2.3
Log Po/w (SILICOS-IT) : -1.93
Consensus Log Po/w : -1.09

Druglikeness

Lipinski : 0.0
Ghose : None
Veber : 1.0
Egan : 1.0
Muegge : 0.0
Bioavailability Score : 0.56

Water Solubility

Log S (ESOL) : -0.63
Solubility : 66.8 mg/ml ; 0.233 mol/l
Class : Very soluble
Log S (Ali) : -0.96
Solubility : 31.4 mg/ml ; 0.109 mol/l
Class : Very soluble
Log S (SILICOS-IT) : -0.83
Solubility : 42.4 mg/ml ; 0.148 mol/l
Class : Soluble

Medicinal Chemistry

PAINS : 0.0 alert
Brenk : 1.0 alert
Leadlikeness : 0.0
Synthetic accessibility : 3.39

Safety of [ 147127-20-6 ]

Signal Word:Danger Class:6.1
Precautionary Statements:P264-P270-P301+P310+P330-P405-P501 UN#:2811
Hazard Statements:H301 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 147127-20-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 147127-20-6 ]
  • Downstream synthetic route of [ 147127-20-6 ]

[ 147127-20-6 ] Synthesis Path-Upstream   1~2

  • 1
  • [ 147127-20-6 ]
  • [ 379270-37-8 ]
Reference: [1] Nucleosides, Nucleotides and Nucleic Acids, 2001, vol. 20, # 4-7, p. 621 - 628
[2] Patent: US2013/90473, 2013, A1,
[3] Patent: US2013/90473, 2013, A1,
[4] Patent: US2016/115186, 2016, A1,
[5] Patent: US2017/56423, 2017, A1,
[6] Patent: WO2017/221189, 2017, A1,
[7] Patent: WO2017/221189, 2017, A1,
[8] Patent: CN108409790, 2018, A,
[9] Patent: CN108409788, 2018, A,
  • 2
  • [ 147127-20-6 ]
  • [ 108-95-2 ]
  • [ 379270-37-8 ]
  • [ 383365-04-6 ]
Reference: [1] Patent: CN106478725, 2017, A,
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