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[ CAS No. 1462-37-9 ] {[proInfo.proName]}

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Chemical Structure| 1462-37-9
Chemical Structure| 1462-37-9
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Product Citations

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Senevirathne, Priyangika Prasadini ;

Abstract: Reactive oxygen species are a group of highly reactive oxygen-containing entities that are important at a cellular level for multiple biological processes. Low concentrations of ROS can be beneficial as powerful signaling molecules in those biological processes, although excessive concentrations can promote high levels of DNA damage and a variety of diseases such as skin cancer. A newly identified intracellular ROS production source in skin cells is NADPH oxidases. Out of the NOX enzyme family, the NOX1 holoenzyme is most abundantly expressed in the human keratinocyte cells. UV radiation can trigger the activation of NOX1 isoforms which stimulate the assembling of member CYBA and the cytoplasmic protein NOXO1. Inhibition of these enzymes represents a catalytic approach toward reducing ROS for the prevention of ROS inducible diseases. Key disease states include melanoma induced by UV exposure. The first half of the dissertation focuses on investigating new small molecule inhibitors of a key NOX1 holoenzyme to address these challenges. We designed a series of molecules by optimizing the structure of diapocynin and evaluated by in-silico docking methods to determine the binding affinity with NOXO1 cytoplasmic protein (1WLP crystal structure). And have synthesized the series of target molecules for the structure-activity relationship studies. In the first section of the project, we discovered that inhibitor NOX_inh_5 was not cytotoxic, but instead improved the viability of human primary cells from UV exposure, decreased the cellular stress in human skin through the p53 pathway, and reduced the UV-induced DNA damage as monitored by quantification of cyclobutane dimer formation after UV exposure. Then, we characterized the inhibition potential of NOX_inh_5 by using an Isothermal calorimetric (ITC) binding assay and heteronuclear single quantum coherence (HSQC) technique and revealed that the candidate iii molecule can prevent the complex formation of NOXO1 and CYBA membrane protein. In the second section of the project, we did a structure-activity relationship study for the NOX_inh_5 small molecule to optimize the biological characteristics. The last section of the dissertation discussed the development of ROS sensible prodrug to combat the opioid overdose crisis. Here we used oxidative stress conditions caused by opioid overdose to activate the prodrug. Even though opioid antagonist naloxone has a high affinity to bind with opioid receptors to block opioid-induced activation, it is metabolically unstable and has a short half-life of around 33 min. We developed a peroxide-induced prodrug to overcome this issue that can release a steady stream of naloxone. This allows the concentration of naloxone to remain high for longer periods.

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Product Details of [ 1462-37-9 ]

CAS No. :1462-37-9 MDL No. :MFCD01321307
Formula : C9H11BrO Boiling Point : -
Linear Structure Formula :- InChI Key :FWOHDAGPWDEWIB-UHFFFAOYSA-N
M.W : 215.09 Pubchem ID :73833
Synonyms :
Chemical Name :((2-Bromoethoxy)methyl)benzene

Calculated chemistry of [ 1462-37-9 ]      Expand+

Physicochemical Properties

Num. heavy atoms : 11
Num. arom. heavy atoms : 6
Fraction Csp3 : 0.33
Num. rotatable bonds : 4
Num. H-bond acceptors : 1.0
Num. H-bond donors : 0.0
Molar Refractivity : 49.98
TPSA : 9.23 ?2

Pharmacokinetics

GI absorption : High
BBB permeant : Yes
P-gp substrate : No
CYP1A2 inhibitor : Yes
CYP2C19 inhibitor : No
CYP2C9 inhibitor : No
CYP2D6 inhibitor : Yes
CYP3A4 inhibitor : No
Log Kp (skin permeation) : -5.8 cm/s

Lipophilicity

Log Po/w (iLOGP) : 2.39
Log Po/w (XLOGP3) : 2.55
Log Po/w (WLOGP) : 2.45
Log Po/w (MLOGP) : 2.64
Log Po/w (SILICOS-IT) : 3.03
Consensus Log Po/w : 2.61

Druglikeness

Lipinski : 0.0
Ghose : None
Veber : 0.0
Egan : 0.0
Muegge : 1.0
Bioavailability Score : 0.55

Water Solubility

Log S (ESOL) : -2.92
Solubility : 0.259 mg/ml ; 0.0012 mol/l
Class : Soluble
Log S (Ali) : -2.39
Solubility : 0.874 mg/ml ; 0.00406 mol/l
Class : Soluble
Log S (SILICOS-IT) : -4.21
Solubility : 0.0132 mg/ml ; 0.0000615 mol/l
Class : Moderately soluble

Medicinal Chemistry

PAINS : 0.0 alert
Brenk : 1.0 alert
Leadlikeness : 1.0
Synthetic accessibility : 1.76

Safety of [ 1462-37-9 ]

Signal Word:Danger Class:9
Precautionary Statements:P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P310-P362+P364-P403+P233-P501 UN#:3334
Hazard Statements:H315-H318-H335-H411 Packing Group:Ⅲ
GHS Pictogram:

Application In Synthesis of [ 1462-37-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1462-37-9 ]

[ 1462-37-9 ] Synthesis Path-Downstream   1~5

  • 1
  • [ 1462-37-9 ]
  • [ 95656-88-5 ]
  • [ 1404531-44-7 ]
YieldReaction ConditionsOperation in experiment
With tetra-(n-butyl)ammonium iodide; sodium hydride; In tetrahydrofuran; mineral oil; at 0 - 80℃; A solution of 1.29 g of <strong>[95656-88-5]benzyl 3-hydroxypyrrolidine-1-carboxylate</strong> in 80 ml of THF is cooled to 0 C., 0.245 g of 60% NaH in oil is added and then 1.26 g of [(2-bromoethoxy)methyl]benzene and 0.108 g of tetrabutylammonium iodide and it is heated at 80 C. for 3 hours. 0.28 g of NaH and 0.40 g of [(2-bromoethoxy)methyl]benzene are added and it is heated at 80 C. for 2 hours. The reaction mixture is concentrated under vacuum, the residue is extracted with DCM, the organic phase is washed with 0.1M HCl solution, with a saturated solution of NaHCO3, it is dried and the solvent is evaporated under vacuum. The product thus obtained is purified by preparative HPLC and 0.46 g of the expected compound is obtained.
With tetra-(n-butyl)ammonium iodide; sodium hydride; In tetrahydrofuran; oil; at 80℃; for 5h; Preparation 7.92-(Pyrrolidin-3-yloxy)ethanol.Step 1 : Benzyl 3-(2-benzyloxyethoxy)pyrrolidine-1 -carboxylate.A solution of 1 .29 g of benzyl 3-hydroxypyrrolidine-1 -carboxylate in 80 ml of THF is cooled to 0C, 0.245 g of 60% NaH in oil is added and then 1 .26 g of [(2- bromoethoxy)methyl]benzene and 0.108 g of tetrabutylammonium iodide and it is heated at 80C for 3 hours. 0.28 g of NaH and 0.40 g of [(2- bromoethoxy)methyl]benzene are added and it is heated at 80C for 2 hours. The reaction mixture is concentrated under vacuum, the residue is extracted with DCM, the organic phase is washed with 0.1 M HCI solution, with a saturated solution of NaHC03, it is dried and the solvent is evaporated under vacuum. The product thus obtained is purified by preparative HPLC and 0.46 g of the expected compound is obtained.
  • 2
  • [ 1123-93-9 ]
  • [ 1462-37-9 ]
  • C16H16N2OS [ No CAS ]
YieldReaction ConditionsOperation in experiment
285 mg To a stirred solution of benzo[cf]thiazol-5-amine (250 mg, 1.66 mmol) in acetonitrile (5 mL) were added the K2CO3 (276 mg, 2.00 mmol) in portion wise over the period of 10 min at 0 °C and the reaction mixture heated at 65 °C for 30 min. Then the temperature was brought to 30 °C, ((2-bromoethoxy)methyl)benzene (0.290 mL, 1.83 mmol) was added the resulting reaction mixture was refluxed for 24h. The reaction mixture was concentrated to dryness; the crude material dissolved in water (30 mL), washed with ether (2 x 30 mL) to remove organic impurities and the aqueous layer neutralized with 1.5N HC1 to pH 7 and extracted with ether (3 x 50 mL). The combined organic layer was washed with water (30 mL), brine (30 mL), dried (Na2S04), filtered, concentrated and the crude product was purified by silica gel chromatography (24 g Redisep? column, eluting with 30percent EtOAc in n-hexane) to afford the title compound (285 mg) as light brown solid. LC-MS Retention Time = 2.56 min; m/z = 285.2 [M+H]+. Column: KINETIX XB-C18, 75x3 mm, 2.6 muiotaeta; Flow rate: 1 mL/min; Mobile Phase A: 10 mM HCOONH4 in 98percent Water/ 2percent ACN; Mobile Phase B: 10 mM HCOONH4 in 2percent Water/ 98percent ACN; 20percent B to 100percent B over 4 min, then hold for 0.6 min at 100percent B with flow rate of 1.5 mL/min; Detection: UV at 220 nm. 1H NMR (400 MHZ, CDCl3) delta 8.90 (s, 1H), 7.70 (d, J=8 Hz, 1H), 7.36 -7.25 (m, 6H), 6.83 (dd, J=8.8, 2.0 Hz, 1H), 4.57 (s, 2H), 4.24 (br s, 1H), 3.76 (t, J=5.2 Hz, 2H), 3.42 (m, 2H).
  • 3
  • [ 42726-73-8 ]
  • [ 1462-37-9 ]
  • 1-tert-butyl 3-methyl 2-(2-benzyloxyethyl)malonate [ No CAS ]
YieldReaction ConditionsOperation in experiment
65% General procedure: alpha-Monosubstituted malonic diester 1 was synthesized according to the reported procedure as follows.3 tert-Butyl methyl malonate was purchased from Kanto Chemical, and used without further purification. The physical properties and spectral data of the new compounds, 2-(2-methylbenzyl)malonate 1g, 2-prenylmalonate 1l, and 2-(2-benzyloxyethyl)malonate 1o, are listed below. A 100 mL round-bottom flask equipped with a stirring bar was charged with <strong>[42726-73-8]tert-butyl methyl malonate</strong> (846 muL, 5.0 mmol) and DMF (10 mL). To the solution, sodium hydride (60percent oil suspension, 200 mg, 5.0 mmol) was added. The reaction was allowed to stir at 0 °C for 30 min. To the mixture, corresponding alkyl halide (5.0 mmol) was added at 0 °C and the mixture was stirred at room temperature for 24 h. To the reaction mixture, H2O was added, and the mixture was extracted with CH2Cl2 (3 * 20 mL), dried over MgSO4, and concentrated in vacuo. The remaining residue was purified by silica gel column chromatography (hexane/ethyl acetate) to afford the desired product 1.
  • 4
  • [ 109-11-5 ]
  • [ 1462-37-9 ]
  • [ 892871-54-4 ]
YieldReaction ConditionsOperation in experiment
49% To a solution of <strong>[109-11-5]morpholin-3-one</strong> (cas: 109-11-5, 2 g, 19.8 mmol) in anhydrous DMF (25 mL) was added NaH (60% dispersion in mineral oil, 1.98 g, 2.5 equiv.) at 0 C under N2. The reaction mixture was stirred for 30 minutes and then ((2- bromoethoxy)methyl)benzene (cas: 1462-37-9, 1.98 g, 2.5 equiv.) was added to the reaction mixture, which was then allowed to warm to ambient temperature. After 12 hours, analysis by LC-MS indicated completion of the reaction. The reaction mixture was quenched with H20 (20 mL) and extracted with EtOAc (20 mL x 3). The combined organic extracts were concentrated under reduced pressure to give the crude product, which was purified by silica gel chromatography (Petroleum ether: EtOAc = 1 :4) to provide morpholinone 1-339 as a pale oil (2.3 g, 49% yield). MS (ESI, pos. ion) m/z: 236(M+l).
  • 5
  • [ 126-33-0 ]
  • [ 1462-37-9 ]
  • 2-(2-(benzyloxy)ethyl)tetrahydrothiophene 1,1-dioxide [ No CAS ]
YieldReaction ConditionsOperation in experiment
With n-butyllithium; In tetrahydrofuran; at -78 - 20℃; A solution of I-16A (2.362 mL, 24.96 mmol) in THF (50 mL) was cooled to -78 C. To the chilled solution was added nBuLi (10.98 mL, 27.5 mmol) dropwise, followed by dropwise addition of benzyl-2-bromoethyl ether (3.99 mL, 25.2 mmol). The resulting solution was allowed to slowly warm to RT. Upon completion of the reaction, the mixture was cooled to 0 C. and quenched with H2O. The aqueous mixture was diluted with EtOAc. The phases were separated and the organic layer was washed with 2 M HCl and brine, dried over sodium sulfate, and concentrated under reduced pressure. The oily residue was purified by column chromatography (SiO2, 0-50% EtOAc/heptane) to afford I-16B as a colorless oil. LCMS m/z: 255 (M+1). 1H NMR (400 MHz, CDCl3) delta ppm 1.73-1.90 (m, 2H) 2.02-2.13 (m, 1H) 2.14-2.39 (m, 3H) 2.94-3.03 (m, 1H) 3.11-3.24 (m, 2H) 3.59-3.71 (m, 2H) 4.46-4.59 (m, 2H) 7.27-7.41 (m, 5H).
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