[ CAS No. 1450-75-5 ] {[proInfo.proName]}

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Quality Control of [ 1450-75-5 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 1450-75-5 ]

SDS Specification

Alternatived Products of [ 1450-75-5 ]

Product Details of [ 1450-75-5 ]

CAS No. :	1450-75-5	MDL No. :	MFCD00191850
Formula :	C₈H₇BrO₂	Boiling Point :	-
Linear Structure Formula :	C₆H₃Br(OH)C(O)CH₃	InChI Key :	HQCCNFFIOWYINW-UHFFFAOYSA-N
M.W :	215.04	Pubchem ID :	95991
Synonyms :

Calculated chemistry of [ 1450-75-5 ] Expand+

Physicochemical Properties

Num. heavy atoms :	11
Num. arom. heavy atoms :	6
Fraction Csp3 :	0.12
Num. rotatable bonds :	1
Num. H-bond acceptors :	2.0
Num. H-bond donors :	1.0
Molar Refractivity :	46.36
TPSA :	37.3 ?2

Pharmacokinetics

GI absorption :	High
BBB permeant :	Yes
P-gp substrate :	No
CYP1A2 inhibitor :	Yes
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-5.69 cm/s

Lipophilicity

Log Po/w (iLOGP) :	2.04
Log Po/w (XLOGP3) :	2.7
Log Po/w (WLOGP) :	2.36
Log Po/w (MLOGP) :	1.86
Log Po/w (SILICOS-IT) :	2.35
Consensus Log Po/w :	2.26

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	0.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	-3.21
Solubility :	0.132 mg/ml ; 0.000614 mol/l
Class :	Soluble
Log S (Ali) :	-3.14
Solubility :	0.157 mg/ml ; 0.000731 mol/l
Class :	Soluble
Log S (SILICOS-IT) :	-3.02
Solubility :	0.207 mg/ml ; 0.000962 mol/l
Class :	Soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	0.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	1.36

Safety of [ 1450-75-5 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P305+P351+P338	UN#:	N/A
Hazard Statements:	H315-H319-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 1450-75-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 1450-75-5 ]
Downstream synthetic route of [ 1450-75-5 ]

[ 1450-75-5 ] Synthesis Path-Upstream 1~1

1
[ 1450-75-5 ]
[ 33839-11-1 ]

Reference： [1] Bulletin de la Societe Chimique de France, 1969, p. 781 - 787

[ 1450-75-5 ] Synthesis Path-Downstream 1~11

1
[ 1450-75-5 ]
[ 33839-11-1 ]

Reference： [1]Bulletin de la Societe Chimique de France,1969,p. 781 - 787

2
[ 72287-26-4 ]
[ 477251-79-9 ]
[1,1'-bis(diphenylphosphino)ferrocene]dichloronickel [ No CAS ]
[ 1450-75-5 ]
[ 497-19-8 ]
[ 73183-34-3 ]
[ 477252-06-5 ]

Yield	Reaction Conditions	Operation in experiment
	With potassium acetate; In hexane; N,N-dimethyl-formamide;	Example 23 N-Isopropyl-1-[3-(3-Acetyl-4-Hydroxyphenyl)Phenyl]-1,4-Dihydro[1,8]Naphthyridin-4-One-3-Carboxamide A mixture of 5'-bromo-2'-hydroxyacetophenone, diboron pinacol ester (1.25 eq), potassium acetate (3 eq) and [1,1'-bis (diphenylphosphino)ferrocene]dichloropalladium(II) (0.05 eq) in N,N-dimethylformamide (10 ml/mmol) was stirred at 80° C. for 3 hours and cooled down. A solution of N-Isopropyl-1-(3-bromophenyl)-1,4-dihydro[1,8]naphthyridin-4-one-3-carboxamide from Example 1, Step 4 (0.75 eq) in N,N-dimethylformamide (7 ml/mmol), [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II) (0.05 eq) and 2M aqueous sodium carbonate (8.5 eq) were added and the resulting mixture was stirred at 80° C. for 2.5 hours. The cooled mixture was partitioned between ethyl acetate and water and the product from the organic phase was chromatographed on silica gel eluding with 60percent ethyl acetate in hexane to afford the title compound as a light yellow solid. 1H NMR (Acetone-d6) delta 1.24 (d, 6H), 2.75 (s, 3H), 4.19 (m, 1H), 7.06 (d, 1H), 7.59-7.63 (m, 2H), 7.72 (t, 1H), 7.92 (d, 1H), 7.97 (d, 1H), 8.02 (s, 1H), 8.33 (s, 1H), 8.73 (m, 1H), 8.78 (dd, 1H), 8.90 (s, 1H), 9.65 (br, NH).

Reference： [1]Patent: US2003/96829,2003,A1

3
[ 1450-75-5 ]
[ 105-58-8 ]
[ 4139-61-1 ]

Yield	Reaction Conditions	Operation in experiment
71%	With sodium hydride; In toluene; at 100℃; for 4.5h;Cooling with ice;	2 (74 mmol) and diethyl carbonate (111 mmol) in toluene (160 mL) were added dropwise to sodium hydride (369 mmol) in toluene (50 mL) in ice-water bath. The mixture was stirred at ice bath for 30 min and at 100C for 4 h. The sodium hydride was quenched with water, acidized with hydrochloric acid and then the suspension was filtered separately, and the solid collected from this filtration was washed with toluene and water for three times. The solid dried at room temperature with phosphorus pentoxide. 3: yield 71%. 1H NMR (400MHz, CDCl3): delta 12.17 (s, 1H), 7.83 (d, J=2.45, 1H), 7.55 (dd, J=2.4Hz, 8.8Hz, 1H), 6.90 (d, J=9.2Hz, 1H), 2.63 (s, 3H) ppm.
70%	With sodium hydride; In toluene; at 100℃; for 4.5h;Cooling with ice;	General procedure: 2a-2c (23.1 mmol) and diethyl carbonate (34.7 mmol, 4.14 g) in toluene (10 mL) were added dropwise to sodium hydride (115 mmol, 4.7 g) in toluene (50 mL) in ice-water bath. The mixture was stirred at ice bath for 30 min and at 100 ? for 4 h. The sodium hydride was quenched with water, acidized with hydrochloric acid and then the suspension was filtered separately, and the solid collected from this filtration was washed with toluene and water for three times. The solid dried at room temperature with phosphorus pentoxide. 3a: yield 70%. HPLC purity: 96.9%.1H NMR (400 MHz, d6-DMSO): delta 5.62 (s, 1H), 7.36 (d, J = 8.8 Hz, 1H), 7.81 (dd, J = 2.4 Hz, 8.8 Hz, 1H), 7.90 (d, J = 2.0 Hz, 1H), 12.51 (br s, 1H). 3b: yield 67%. HPLC purity: 96.9%. 3c: yield 86%. HPLC purity: 98.2%.1H NMR (400 MHz, d6-DMSO): delta 3.83 (s, 3H), 5.51 (s, 1H), 6.92-6.96 (m, 2H), 7.71 (d, J = 8.4 Hz, 1H), 12.51 (br s, 1H).
69%	With sodium hydride; In toluene; at 0℃; for 4.5h;Reflux;	General procedure: To a stirred mixture of 5a-f (1.15 mmol) and sodium hydride (138 mg, 5.75 mmol) in 5 ml dry toluene, a solution of the diethyl carbonate (1.15 mmol) in dry toluene was dropped. The mixture was reacted at 0C for 30 min, then heated to reflux and reacted for another 4 h. The reaction mixture was quenched with water (20 mL) at ice bath and neutralized to pH 7 with 2 N HCl. The precipitate was filtered, washed with cold water and dried to get 6a-f.

		General procedure: Preparation of 4-hydroxycoumarin (step 1)9aA solution of 2-hydroxy-5-methoxyacetophenone (9 mmol,1.5 g) in toluene (15 mL) was added dropwise to a dry three-neckround-bottom flask containing sodium hydride (60% w/w suspension,45 mmol, 1.8 g) in toluene (10 mL). This was done under N2atmosphere at ice bath temperature. The mixturewas stirred at thesame temperature for 15 min and followed by the dropwise additionof diethylcarbonate (13.5 mmol, 1.6 g) in toluene (10 mL). Aftercomplete addition, the reaction mixturewas stirred at rt for 30 minand refluxed for five more hours. The reaction mixture wasquenched at ice bath temperature by slow addition of water(20 mL) and acidified with 2 N HCl. The product obtained as a solidprecipitate was filtered, washed with water, and dried under vacuumto get 4-hydroxy-6-methoxy-2H-chromen-2-one as a whitesolid (1.4 g, 82%). This product was directly used in step 2.
	With sodium hydride; In mineral oil; at 100℃; for 4h;	A mixture of 2-hydroxy-5-bromoacetophenone (5g, 23.1mmol) and diethyl carbonate (4.14g, 34.7mmol) were combined then added toluene (10ml) was dissolved. Sodium hydride (4.7g, mass fraction of 60%, 115mmol) and toluene (50ml) After mixing, the toluene was dissolved 2-hydroxy-5-bromoacetophenone and diethyl carbonate mixed solution was slowly added dropwise under ice bath among them. After dropping about 20min,The reaction temperature was raised to 100 deg.] C for 4 hours. After completion of the reaction, insolubles were filtered off the solid, the filter cake washed with toluene, repeating the first layer, followed by two to three times a small amount of water. With phosphorus pentoxide at room temperature under reduced pressure and dried to give a yellow solid (3.9g, 70% crude yield).
		In a 250 mL two-neck round-bottom flask, 9 mmol of ohydroxyacetophenonein 15 mL toluene was slowly added to sodiumhydride (60% w/w suspension, 5 equiv, 45 mmol, 1.8 g) intoluene (10 mL) under N2 atmosphere at 0 C. After 15 min,13.5 mmol of diethyl carbonate in 10 mL toluene was added dropwise,and the mixture was stirred at room temperature for 30 minand refluxed until the reaction finished (monitored by TLC (ThinLayer Chromatography)). After the mixture cooled to room temperature,the reaction was quenched by slowly addition of 2 N hydrochloricacid. The resulting precipitate was further purified by ashort silica gel column chromatography to give a white solid.

Reference： [1]New Journal of Chemistry,2018,vol. 42,p. 13985 - 13997
[2]European Journal of Medicinal Chemistry,2016,vol. 114,p. 232 - 243
[3]Bioorganic and Medicinal Chemistry Letters,2014,vol. 24,p. 799 - 807
[4]Bioorganic and Medicinal Chemistry Letters,2019,vol. 29,p. 2129 - 2135
[5]Bioorganic and Medicinal Chemistry Letters,2010,vol. 20,p. 3649 - 3653
[6]Advanced Synthesis and Catalysis,2013,vol. 355,p. 2550 - 2557
[7]Tetrahedron,2014,vol. 70,p. 6995 - 7005
[8]Journal of Heterocyclic Chemistry,2015,vol. 52,p. 1014 - 1018
[9]Patent: CN103254203,2016,B .Location in patent: Paragraph 0062; 0072; 0073
[10]Tetrahedron,2018,vol. 74,p. 970 - 974
[11]Bioorganic and medicinal chemistry letters,2020

4
[ 1450-75-5 ]
[ 5676-56-2 ]
[ 42524-21-0 ]

Yield	Reaction Conditions	Operation in experiment
65%; 7%	With acetylhydroxamic acid; sulfuric acid; In acetonitrile; at 80℃; under 1292.9 Torr; for 0.166667h;Microwave irradiation;	General procedure: 2-Hydroxy acetophenone 4a (1.0 g, 7.4 mmol), acetohydroxamic acid (0.83 g, 11.0 mmol), acetonitrile (3 ml), and conc. H2SO4 (0.2 ml) were taken into a 10 ml pressure tube and subjected to microwave heating (CEM discover, 360 W, 80 C, 25 psi) for 8 min. Next, the reaction mixture was diluted with ethyl acetate (3 ml) and to this; saturated sodium bicarbonate solution (5 ml) was added drop-wise. The mixture was extracted with ethyl acetate (2 × 10 ml) and the combined organic layer was washed with saturated NaCl solution, dried over anhy. Na2SO4, and concentrated under reduced pressure. Purification of the mixture by normal column chromatography (silica gel 60-120 mesh, ethyl acetate/hexane: 1:9) gave benzoxazole 5a (0.67 g, 70%) in the form of a yellow oil and 2-hydroxy acetophenone oxime 6a (68 mg, 6%, mp 104-107 C) in the form of a white powder.

Reference： [1]Tetrahedron Letters,2011,vol. 52,p. 6103 - 6107
[2]Catalysis Letters,2015,vol. 145,p. 939 - 946

5
[ 118-93-4 ]
[ 1836-05-1 ]
[ 1450-75-5 ]

Yield	Reaction Conditions	Operation in experiment
26%; 61%	With Oxone; ammonium bromide; In methanol; at 20℃; for 4.5h;	General procedure: Oxone (1.352 g, 2.2 mmol) was added to the well stirred solution of substrate (2 mmol) and NH4Br (0.215 g, 2.2 mmol) in methanol (10 ml) and the reaction mixture was allowed to stir at room temperature (or reflux temperature). After completion of the reaction, as monitored by TLC, the reaction mixture was quenched with aqueous sodium thiosulfate, and extracted with ethyl acetate (3×25 ml). Finally, the combined organic layer was washed with water, dried over anhydrous sodium sulfate, filtered and removal of solvent in vacuo yielded a crude residue, which was further purified by column chromatography over silica gel (finer than 200 mesh) to afford pure products. All the products were identified on the basis of 1H NMR and mass spectral data.

Reference： [1]Tetrahedron Letters,2012,vol. 53,p. 191 - 195
[2]European Journal of Organic Chemistry,2019,vol. 2019,p. 4593 - 4596

6
[ 118-93-4 ]
[ 22362-66-9 ]
[ 1836-05-1 ]
[ 1450-75-5 ]

Yield	Reaction Conditions	Operation in experiment
52%Chromat.; 6%Chromat.; 19%Chromat.	With N-Bromosuccinimide; In acetonitrile; at 20℃; for 2h;	General procedure: Reaction conditions: Thiourea (5.1 molpercent, 2 mg, 0.026 mmol) was added to an acetonitrile solution (10 mL) containing NBS (1.15 equiv, 104.4 mg, 0.587 mmol). Anisole (56.3 mg, 0.51 mmol) was added immediately to the resulting stirred solution and allowed to stir at room temperature for 10 min. The reaction was quenched by the addition of 10percent aqueous solution of Na2S2O3 (10 mL) and extracted with ethyl acetate (70 mL). The organic solution was then washed with additional 10percent Na2S2O3 (2 * 10 mL), followed by deionized water (3 * 15 mL) and brine (2 * 10 mL). The organic solution was then dried over anhydrous Na2SO4 and the solvent was evaporated in vacuo. The major product of each reaction was isolated by centrifugal thin-layer chromatography using a 2 mm thick silica gel 60GF254 coated plate (5percent CH2Cl2/hexanes). The products reported herein are known compounds and were characterised by GC-MS, IR, 1H and 13C NMR. Their spectroscopic data are in agreement with those reported in the literature.

Reference： [1]Journal of Organic Chemistry,2012,vol. 77,p. 5823 - 5828
[2]Tetrahedron,2017,vol. 73,p. 6564 - 6572

7
[ 1450-75-5 ]
[ 175883-62-2 ]
1-(6-hydroxy-3-(3-methyl-4-methoxyphenyl)phenyl)ethanone [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,2015,vol. 58,p. 1184 - 1194

8
[ 1450-75-5 ]
[ 5676-56-2 ]

Reference： [1]Journal of Organic Chemistry,2015,vol. 80,p. 8657 - 8667
[2]Catalysis Letters,2015,vol. 145,p. 939 - 946

9
[ 1450-75-5 ]
[ 5676-56-2 ]
5-bromo-N-methylbenzo[d]oxazol-2-amine [ No CAS ]

Reference： [1]Journal of Organic Chemistry,2015,vol. 80,p. 8657 - 8667

10
[ 1450-75-5 ]
[ 5676-56-2 ]
[ 42524-21-0 ]
[ 6329-74-4 ]

Reference： [1]Catalysis Letters,2015,vol. 145,p. 939 - 946

11
[ 1450-75-5 ]
[ 5676-56-2 ]
[ 6329-74-4 ]

Reference： [1]Catalysis Letters,2015,vol. 145,p. 939 - 946

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Technical Information

? Acidity of Phenols ? Alkyl Halide Occurrence ? Appel Reaction ? Baeyer-Villiger Oxidation ? Barbier Coupling Reaction ? Baylis-Hillman Reaction ? Benzylic Oxidation ? Birch Reduction ? Blanc Chloromethylation ? Bucherer-Bergs Reaction ? Buchwald-Hartwig C-N Bond and C-O Bond Formation Reactions ? Chan-Lam Coupling Reaction ? Chugaev Reaction ? Clemmensen Reduction ? Corey-Bakshi-Shibata (CBS) Reduction ? Corey-Chaykovsky Reaction ? Corey-Kim Oxidation ? Dess-Martin Oxidation ? Electrophilic Substitution of the Phenol Aromatic Ring ? Etherification Reaction of Phenolic Hydroxyl Group ? Fischer Indole Synthesis ? Friedel-Crafts Reaction ? General Reactivity ? Grignard Reaction ? Halogenation of Phenols ? Henry Nitroaldol Reaction ? Hiyama Cross-Coupling Reaction ? Horner-Wadsworth-Emmons Reaction ? Hydride Reductions ? Hydrogenolysis of Benzyl Ether ? Jones Oxidation ? Kinetics of Alkyl Halides ? Kumada Cross-Coupling Reaction ? Lawesson's Reagent ? Leuckart-Wallach Reaction ? Martin's Sulfurane Dehydrating Reagent ? McMurry Coupling ? Meerwein-Ponndorf-Verley Reduction ? Mitsunobu Reaction ? Moffatt Oxidation ? Oxidation of Alcohols by DMSO ? Oxidation of Phenols ? Passerini Reaction ? Paternò-Büchi Reaction ? Pechmann Coumarin Synthesis ? Petasis Reaction ? Peterson Olefination ? Pictet-Spengler Tetrahydroisoquinoline Synthesis ? Preparation of Alcohols ? Preparation of Aldehydes and Ketones ? Preparation of Alkylbenzene ? Preparation of Amines ? Prins Reaction ? Reactions of Alcohols ? Reactions of Aldehydes and Ketones ? Reactions of Alkyl Halides with Reducing Metals ? Reactions of Amines ? Reactions of Benzene and Substituted Benzenes ? Reactions of Dihalides ? Reactions with Organometallic Reagents ? Reformatsky Reaction ? Reimer-Tiemann Reaction ? Ritter Reaction ? Robinson Annulation ? Schlosser Modification of the Wittig Reaction ? Schmidt Reaction ? Sharpless Olefin Synthesis ? Specialized Acylation Reagents-Ketenes ? Stille Coupling ? Stobbe Condensation ? Substitution and Elimination Reactions of Alkyl Halides ? Suzuki Coupling ? Swern Oxidation ? Tebbe Olefination ? Ugi Reaction ? Vilsmeier-Haack Reaction ? Wittig Reaction ? Wolff-Kishner Reduction

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P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

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[ CAS No. 1450-75-5 ] {[proInfo.proName]}

Quality Control of [ 1450-75-5 ]

Related Doc. of [ 1450-75-5 ]

Product Details of [ 1450-75-5 ]

Calculated chemistry of [ 1450-75-5 ] Expand+

Physicochemical Properties

Pharmacokinetics

Lipophilicity

Druglikeness

Water Solubility

Medicinal Chemistry

Safety of [ 1450-75-5 ]

Application In Synthesis of [ 1450-75-5 ]

[ 1450-75-5 ] Synthesis Path-Upstream 1~1

[ 1450-75-5 ] Synthesis Path-Downstream 1~11

Technical Information

Related Functional Groups of [ 1450-75-5 ]

Aryls

Bromides

Ketones

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

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[ 1450-75-5 ]