Alternatived Products of [ 140-28-3 ]
Product Details of [ 140-28-3 ]
| CAS No. : | 140-28-3 |
MDL No. : | MFCD00004771 |
| Formula : |
C16H20N2
|
Boiling Point : |
No data available |
| Linear Structure Formula : | (C6H5CH2)2NHCH2CH2NH |
InChI Key : | JUHORIMYRDESRB-UHFFFAOYSA-N |
| M.W : |
240.34
|
Pubchem ID : | 8793 |
| Synonyms : |
|
Application In Synthesis of [ 140-28-3 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Upstream synthesis route of [ 140-28-3 ]
- Downstream synthetic route of [ 140-28-3 ]
- 1
-
[ 57-92-1 ]
-
[ 140-28-3 ]
-
[ 47896-20-8 ]
- 2
-
[ 140-28-3 ]
-
[ 65838-10-0 ]
- 3
-
[ 5027-32-7 ]
-
copper(II) perchlorate hexahydrate
[ No CAS ]
-
[ 140-28-3 ]
-
(tetraacetylethane)bis(N,N'-dibenzyl-1,2-diaminoethane)dicopper(II) perchlorate
[ No CAS ]
- 4
-
[ 140-28-3 ]
-
[ 167366-05-4 ]
-
1,3-dibenzyl-2-(3-bromo-5-thiazolyl)imidazolidine
[ No CAS ]
| Yield | Reaction Conditions | Operation in experiment |
| 32% |
In ethanol; water; at 20℃; |
General procedure: The corresponding aldehydes (1.0 mmol) were added to a solution of N,N'-dibenzyl ethylenediamine (480 mg, 2.0 mmol) in aqueous ethanol (50%, 3 mL). The reaction mixture was stirred at room temperature until the complete consumption of aldehydes, as determined by thin layer chromatography (TLC). The mixture was ltered and the lter cake was washed with a small amount of water and cold ethanol to aord the pure product. |
- 5
-
[ 431-35-6 ]
-
[ 140-28-3 ]
-
[ 131922-05-9 ]
| Yield | Reaction Conditions | Operation in experiment |
|
With sodium borohydrid; dimethyl sulfoxide;palladium; In ethanol; water; |
EXAMPLE 134 2-(Trifluoromethyl)piperazine A 12.3 g portion of bromo-3,3,3-trifluoropropanone was slowly added to 50 ml of dimethyl sulfoxide and stirred under a dry atmosphere for 21 hours and then diluted to 100 ml with ethanol. A solution of 31 g of N,N-dibenzylethylenediamine in 100 ml of ethanol was added dropwise and the mixture was stirred for 8 hours. A 2.43 g portion of sodium borohydride was added over 30 minutes, this mixture was stirred overnight then the ethanol was removed. The dimethyl sulfoxide residue was dissolved in water and extracted with dichloromethane. The extracts were combined, washed with water and brine and then subjected to flash chromatography on a silica gel column, eluding with ether:hexane (3:7). The 2-(trifluoromethyl)dibenzylpiperazine was dissolved in 25 ml of ethanol in an argon flushed Parr bottle. A 0.63 g portion of 10% palladium on carbon was added and the mixture was shaken under 47 lbs. of hydrogen pressure overnight at 40 C. Filtration and evaporation of the solvent gave 0.55 g of 2-(trifluoromethyl)piperazine as a semi-solid. |
Chemistry
Pharmaceutical Intermediates
Inhibitors/Agonists
Material Science
For Research Only
120K+ Compounds
Competitive Price
1-2 Day Shipping
