天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

Home Cart 0 Sign in  

[ CAS No. 124-68-5 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
HazMat Fee +

There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Chemical Structure| 124-68-5
Chemical Structure| 124-68-5
Structure of 124-68-5 * Storage: {[proInfo.prStorage]}

Please Login or Create an Account to: See VIP prices and availability

Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Search after Editing

* Storage: {[proInfo.prStorage]}

* Shipping: {[proInfo.prShipping]}

Quality Control of [ 124-68-5 ]

Related Doc. of [ 124-68-5 ]

Alternatived Products of [ 124-68-5 ]
Product Citations

Product Details of [ 124-68-5 ]

CAS No. :124-68-5 MDL No. :MFCD00008051
Formula : C4H11NO Boiling Point : -
Linear Structure Formula :OHCH2C(CH3)2NH2 InChI Key :CBTVGIZVANVGBH-UHFFFAOYSA-N
M.W : 89.14 Pubchem ID :11807
Synonyms :

Calculated chemistry of [ 124-68-5 ]      Expand+

Physicochemical Properties

Num. heavy atoms : 6
Num. arom. heavy atoms : 0
Fraction Csp3 : 1.0
Num. rotatable bonds : 1
Num. H-bond acceptors : 2.0
Num. H-bond donors : 2.0
Molar Refractivity : 25.25
TPSA : 46.25 ?2

Pharmacokinetics

GI absorption : High
BBB permeant : No
P-gp substrate : No
CYP1A2 inhibitor : No
CYP2C19 inhibitor : No
CYP2C9 inhibitor : No
CYP2D6 inhibitor : No
CYP3A4 inhibitor : No
Log Kp (skin permeation) : -7.4 cm/s

Lipophilicity

Log Po/w (iLOGP) : 1.31
Log Po/w (XLOGP3) : -0.78
Log Po/w (WLOGP) : -0.28
Log Po/w (MLOGP) : -0.18
Log Po/w (SILICOS-IT) : -0.58
Consensus Log Po/w : -0.1

Druglikeness

Lipinski : 0.0
Ghose : None
Veber : 0.0
Egan : 0.0
Muegge : 2.0
Bioavailability Score : 0.55

Water Solubility

Log S (ESOL) : 0.16
Solubility : 130.0 mg/ml ; 1.46 mol/l
Class : Highly soluble
Log S (Ali) : 0.29
Solubility : 173.0 mg/ml ; 1.94 mol/l
Class : Highly soluble
Log S (SILICOS-IT) : -0.07
Solubility : 75.2 mg/ml ; 0.843 mol/l
Class : Soluble

Medicinal Chemistry

PAINS : 0.0 alert
Brenk : 0.0 alert
Leadlikeness : 1.0
Synthetic accessibility : 1.0

Safety of [ 124-68-5 ]

Signal Word:Danger Class:8
Precautionary Statements:P260-P264-P273-P280-P301+P330+P331-P303+P361+P353-P304+P340+P310-P305+P351+P338+P310-P312-P363-P405-P501 UN#:1760
Hazard Statements:H303-H314-H412 Packing Group:Ⅲ
GHS Pictogram:

Application In Synthesis of [ 124-68-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 124-68-5 ]

[ 124-68-5 ] Synthesis Path-Downstream   1~10

  • 1
  • [ 558-42-9 ]
  • [ 124-68-5 ]
  • (β-hydroxy-isobutyl)-(hydroxy-<i>tert</i>-butyl)-amine [ No CAS ]
  • 2
  • [ 14287-61-7 ]
  • [ 124-68-5 ]
  • [ 34575-29-6 ]
  • 3
  • [ 1643-16-9 ]
  • [ 124-68-5 ]
  • [ 184879-00-3 ]
  • 4
  • [ 22280-60-0 ]
  • [ 124-68-5 ]
  • 2-methyl-2-(6-methyl-5-nitro-pyridin-2-ylamino)-propan-1-ol [ No CAS ]
YieldReaction ConditionsOperation in experiment
72% In pentan-1-ol;Heating / reflux; (d) 6-Chloro-3-nitro-2-picoline (6.055 g, 35.1 mmol) and 2-amino-2-methyl-propan-1-ol (6.2 g, 73.7 mmol) were suspended in 1-pentanol (30 ml) and the mixture refluxed under inert atmosphere overnight The thin layer chromatography (dichloromethane 4/EtOAc 1) revealed some remaining starting material, so the reaction was refluxed for another 3.5 hrs. The reaction mixture was cooled and water was added under stirring. A sticky, yellow precipitate was filtered off, washed well with water and dried. The crude product (6.04 g) was re-crystallised from either pentane-acetone or dichloromethane. Collecting the crops furnished 5.71 (72 percent) of 2-methyl-2- (6-methyl-5-nitro-pyridin-2-ylamnio- propan-l-ol as yellow crystals.
  • 5
  • [ 97-08-5 ]
  • [ 124-68-5 ]
  • 4-chloro-3-nitro-(2-hydroxy-1,1-dimethyl-ethyl)-benzenesulfonamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
15% With sodium hydroxide; In water; at 20℃; for 16h; To a stirred solution of 2-amino-2-methyl-1-propanol (3.48 g, 39 mmol) in 1N NaOH (25 ml) was added at room temperature 4-chloro-3-nitrobenzenesulfonyl chloride (5.0 g, 19.5 mmol). The reaction mixture was stirred at room temperature for 16h, poured into brine (50 ml) and extracted with ethyl acetate (3 x 70 ml). The combined organic layers were washed with brine (50 ml), dried (MgS04) and evaporated. The crude product was further purified by column chromatography on silica gel (heptane/ ethyl acetate 1:4) and subsequent crystallization from ethyl acetate/ heptane to yield 4-chloro-3-nitro-(2- hydroxy-1,1-dimethyl-ethyl)-benzenesulfonamide (0.93 g, 15%) as an off-white solid. MS (ISP) 307.0 [(M-H)-]; mp 119C.
  • 6
  • [ 16263-53-9 ]
  • [ 124-68-5 ]
  • · 3-(2-Amino-2-methylpropoxy)-5-chloro-1,2-benzoisoxazole [ No CAS ]
YieldReaction ConditionsOperation in experiment
In tetrahydrofuran; water; ethyl acetate; (1) To a suspension of 0.43 g of 60% (w/w) sodium hydride in 15 ml of tetrahydrofuran is added a solution of 0.80 g of 2-amino-2-methyl-1-propanol in 20 ml of tetrahydrofuran at 20-25 C., and they are refluxed for two hours. To the reaction mixture is added a solution of 2.36 g of <strong>[16263-53-9]3,5-dichloro-1,2-benzoisoxazole</strong> in 20 ml of tetrahydrofuran under reflux, and they are refluxed for a further one hour. After cooling, the solvent is removed by distillation under reduced pressure, and ethyl acetate and water are added to the residue obtained, and after shaking, the organic layer is separated. The separated organic layer is washed with a saturated saline solution, dried over anhydrous magnesium sulfate and then purified by a column chromatography [eluant:chloroform:methanol=20:1], to obtain 1.59 g of oily 3-(2-amino-2-methylpropoxy)-5-chloro-1,2-benzoisoxazole.
  • 7
  • [ 1240361-06-1 ]
  • [ 124-68-5 ]
  • tert-butyl 3-(1-hydroxy-2-methylpropan-2-ylcarbamoyl)-4,5,6,7-tetrahydrobenzo[b]thiophen-2-ylcarbamate [ No CAS ]
YieldReaction ConditionsOperation in experiment
197 mg With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20℃; for 4.0h;Inert atmosphere; 2-tert-Butoxycarbonylamino-4,5,6,7-tetrahydro-benzo[]thiophene-3-carboxylic acid (200 mg, prepared according Y. Huang et al, Chem. Biol. Drug Des. 2010, 76, 116-129) was dissolved in DMF (5 mL) at RT under argon. Then HATU (264 mg), DIPEA (88.7 mg) and 2- amino-2-methylpropan-l-ol (63.1 mg) were added and the reaction solution was stirred at RT for 4 h until TLC (n-heptane/EtOAc: 1/1) indicated completion of the reaction. The reaction mixture was diluted with H20 and extracted with EtOAc. The combined organic layers were washed with 2M aqueous KHCO3 solution, dried over Na2S04 and concentrated in vacuo. The residue was purified by flash chromatography (EtOAc/n-heptane, gradient from 0 to 25%) to give the desired compound as a colorless solid (197 mg). MS (ESI): m/z = 369.1 [M+H] +.
  • 8
  • [ 63089-50-9 ]
  • [ 124-68-5 ]
  • 2,2'-(4-methylbenzene-1,2-diyl)bis(4,4-dimethyl-4,5-dihydro-1,3-oxazole) [ No CAS ]
YieldReaction ConditionsOperation in experiment
92% With zinc(II) triflate; In chlorobenzene; at 135℃; for 24h;Inert atmosphere; General procedure: A 50 mL round bottom flask equipped with a reflux condenser was charged with the appropriate amount of the substituted phthalonitrile (4.0 mM), zinc triflate (5.0 M%, 0.20 mM), and chlorobenzene (30 mL) under argon. The mixture was stirred to dissolve the phthalonitrile and then 2-aminoalcohol (8.0 mM), dissolved in dry chlorobenzene, was slowly added. The temperature was raised to 135 C and the reaction mixture was refluxed for 24 h. The product of the reaction, which was obtained as an oily residue, was dissolved in 30 mL of dichloromethane and then extracted twice with distilled water (20 mL). The aqueous layer was separated and washed with dichloromethane. The separated organic layers were dried using anhydrous sodium sulfate. The dichloromethane was removed under vacuum on a rotary evaporator to give the crude product, which was then purified using silica gel column chromatography with dichloromethane/ether (4/1) as eluent [14, 16, 17].
87% With zinc trifluoromethanesulfonate; In chlorobenzene; for 24h;Reflux; A solution of phthalonitrile derivative and zinc triflate in drychlorobenzene was stirred at room temperature for15 min, and then a solution of aminoalcohol in dry chlorobenzene was slowly added. The temperature was raised to 135C, and the reaction mixture was refluxed for 24 h.
  • 9
  • [ 20197-92-6 ]
  • [ 124-68-5 ]
  • 2-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)-4,5-dimethoxyaniline [ No CAS ]
  • 10
  • [ 18791-99-6 ]
  • [ 124-68-5 ]
  • 2-(4-bromothiophen-2-yl)-4,4-dimethyl-4,5-dihydrooxazole [ No CAS ]
Recommend Products
Same Skeleton Products

Technical Information

Historical Records

Related Functional Groups of
[ 124-68-5 ]

Aliphatic Chain Hydrocarbons

Chemical Structure| 77-86-1

[ 77-86-1 ]

2-Amino-2-(hydroxymethyl)propane-1,3-diol

Similarity: 0.94

Chemical Structure| 1185-53-1

[ 1185-53-1 ]

2-Amino-2-(hydroxymethyl)propane-1,3-diol hydrochloride

Similarity: 0.88

Chemical Structure| 27646-80-6

[ 27646-80-6 ]

2-Methyl-2-(methylamino)propan-1-ol

Similarity: 0.79

Chemical Structure| 534-03-2

[ 534-03-2 ]

2-Aminopropane-1,3-diol

Similarity: 0.75

Chemical Structure| 6976-37-0

[ 6976-37-0 ]

2-(Bis(2-hydroxyethyl)amino)-2-(hydroxymethyl)propane-1,3-diol

Similarity: 0.65

Alcohols

Chemical Structure| 77-86-1

[ 77-86-1 ]

2-Amino-2-(hydroxymethyl)propane-1,3-diol

Similarity: 0.94

Chemical Structure| 1185-53-1

[ 1185-53-1 ]

2-Amino-2-(hydroxymethyl)propane-1,3-diol hydrochloride

Similarity: 0.88

Chemical Structure| 27646-80-6

[ 27646-80-6 ]

2-Methyl-2-(methylamino)propan-1-ol

Similarity: 0.79

Chemical Structure| 534-03-2

[ 534-03-2 ]

2-Aminopropane-1,3-diol

Similarity: 0.75

Chemical Structure| 1305208-37-0

[ 1305208-37-0 ]

(3-Aminooxetan-3-yl)methanol

Similarity: 0.71

Amines

Chemical Structure| 77-86-1

[ 77-86-1 ]

2-Amino-2-(hydroxymethyl)propane-1,3-diol

Similarity: 0.94

Chemical Structure| 1185-53-1

[ 1185-53-1 ]

2-Amino-2-(hydroxymethyl)propane-1,3-diol hydrochloride

Similarity: 0.88

Chemical Structure| 27646-80-6

[ 27646-80-6 ]

2-Methyl-2-(methylamino)propan-1-ol

Similarity: 0.79

Chemical Structure| 874473-14-0

[ 874473-14-0 ]

3-Methyloxetan-3-amine

Similarity: 0.75

Chemical Structure| 534-03-2

[ 534-03-2 ]

2-Aminopropane-1,3-diol

Similarity: 0.75

; ;