天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

Home Cart 0 Sign in  

[ CAS No. 1234616-70-6 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
Chemical Structure| 1234616-70-6
Chemical Structure| 1234616-70-6
Structure of 1234616-70-6 * Storage: {[proInfo.prStorage]}

Please Login or Create an Account to: See VIP prices and availability

Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Search after Editing

* Storage: {[proInfo.prStorage]}

* Shipping: {[proInfo.prShipping]}

Quality Control of [ 1234616-70-6 ]

Related Doc. of [ 1234616-70-6 ]

Alternatived Products of [ 1234616-70-6 ]
Product Citations

Product Details of [ 1234616-70-6 ]

CAS No. :1234616-70-6 MDL No. :MFCD17015892
Formula : C7H2BrCl2N3 Boiling Point : -
Linear Structure Formula :- InChI Key :VPAHKVLQMKEPQW-UHFFFAOYSA-N
M.W : 278.92 Pubchem ID :72207616
Synonyms :

Safety of [ 1234616-70-6 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 1234616-70-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1234616-70-6 ]

[ 1234616-70-6 ] Synthesis Path-Downstream   1~15

  • 1
  • [ 142168-97-6 ]
  • [ 1234616-70-6 ]
YieldReaction ConditionsOperation in experiment
80% With trichlorophosphate; In N,N-dimethyl-formamide; for 6.0h;Reflux; General procedure: 2,4,6-Trichloro-pyrido[2,3-d]pyrimidine (6) (C7H2Cl3N3): A mixture of 50 mL of POCl3, two drops of DMF, and 5 g of 6-chloro-1H-pyrido[2,3-d]pyrimidine-2,4-dione 4 were heated to reflux. After 6 h, the reaction was evaporated under reduced pressure; 400 mL of CH2Cl2 and 20 mL of water were added to the residue at C. The aqueous phase was extracted, the organic layers were combined and then dried over magnesium sulfate. After filtration the filtrate was evaporated under reduced pressure, and then washed with Et2O to obtain compound 6 as a yellow solid in 64% yield.
  • 2
  • methyl 5-bromo-2-(3-(2,2,2-trichloroacetyl)ureido)nicotinate [ No CAS ]
  • [ 1234616-70-6 ]
  • 3
  • [ 50735-34-7 ]
  • [ 1234616-70-6 ]
  • 4
  • [ 142168-97-6 ]
  • [ 1234616-70-6 ]
YieldReaction ConditionsOperation in experiment
64% With N,N-diethylaniline; trichlorophosphate; at 110.0℃; for 5.0h; Prepared from13 (1.02?g, 4.23?mmol) by general procedure C. Yellow solid (755.1?mg, 64%). 1H NMR (CDCl3) delta?=?8.75 (d, 1H, J?=?2.5?Hz), 9.30 (d, 1H, J?=?2.5?Hz). MS (ESI) 279.8 (M+H)+.
  • 5
  • [ 1234616-70-6 ]
  • tert-butyl ((1s,4s)-4-((6-bromo-2-(isopropylamino)pyrido[2,3-d]pyrimidin-4-yl)amino)cyclohexyl)carbamate [ No CAS ]
  • 6
  • [ 1234616-70-6 ]
  • tert-butyl ((1S,4s)-4-((6-bromo-2-(((R)-1-hydroxypropan-2-yl)amino)pyrido[2,3-d]pyrimidin-4-yl)amino)cyclohexyl)carbamate [ No CAS ]
  • 7
  • [ 1234616-70-6 ]
  • tert-butyl ((1s,4s)-4-((6-(3-fluorophenyl)-2-(isopropylamino)pyrido[2,3-d]pyrimidin-4-yl)amino)cyclohexyl)carbamate [ No CAS ]
  • 8
  • [ 1234616-70-6 ]
  • tert-butyl ((1S,4s)-4-((6-(3-fluorophenyl)-2-(((R)-1-hydroxypropan-2-yl)amino)pyrido[2,3-d]pyrimidin-4-yl)amino)cyclohexyl)carbamate [ No CAS ]
  • 9
  • [ 1234616-70-6 ]
  • N4-((1s,4s)-4-aminocyclohexyl)-6-(3-fluorophenyl)-N2-isopropylpyrido[2,3-d]pyrimidine-2,4-diamine [ No CAS ]
  • 10
  • [ 1234616-70-6 ]
  • (R)-2-((4-(((1s,4S)-4-aminocyclohexyl)amino)-6-(3-fluorophenyl)pyrido[2,3-d]pyrimidin-2-yl)amino)propan-1-ol [ No CAS ]
  • 11
  • [ 1234616-70-6 ]
  • 1-((1s,4S)-4-((6-(3-fluorophenyl)-2-(isopropylamino)pyrido[2,3-d]pyrimidin-4-yl)amino)cyclohexyl)-3-((R)-1-hydroxy-3-methylbutan-2-yl)urea [ No CAS ]
  • 12
  • [ 1234616-70-6 ]
  • 1-((1S,4S)-4-((6-(3-fluorophenyl)-2-(((R)-1-hydroxypropan-2-yl)amino)pyrido[2,3-d]pyrimidin-4-yl)amino)cyclohexyl)-3-((R)-1-hydroxy-3-methylbutan-2-yl)urea [ No CAS ]
  • 13
  • [ 247570-24-7 ]
  • [ 1234616-70-6 ]
  • tert-butyl ((1s,4s)-4-((6-bromo-2-chloropyrido[2,3-d]pyrimidin-4-yl)amino)cyclohexyl)carbamate [ No CAS ]
YieldReaction ConditionsOperation in experiment
100% With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20.0℃; for 3.0h; Prepared from 17 (155.7?mg, 0.558?mmol) and N-Boc-cis-1,4-cyclohexanediamine (144?mg, 0.670?mmol) by general procedure D. Slight yellow solid (275.0?mg, quant.). 1H NMR (CDCl3) delta?=?1.46 (s, 9H), 1.87 (m, 8H), 3.71 (m, 1H), 4.43 (m, 1H), 4.64 (br, 1H), 6.09 (br, 1H), 8.26 (d, 1H, J?=?2.4?Hz), 9.02 (d, 1H, J?=?2.4?Hz). MS (ESI) 456.0 (M+H)+.
  • 14
  • [ 1234616-70-6 ]
  • [ 5720-07-0 ]
  • C21H16ClN3O2 [ No CAS ]
YieldReaction ConditionsOperation in experiment
76% With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In toluene; at 110.0℃; for 3.0h; General procedure: To an argon degassed solution of 6-halogeno-2,4-dichloropyrido[2,3-d]pyrimidine 6 or 7 (0.5 mmol) in toluene (6mL) the desired (Het)aryl boronic acid was added then (1.5 equiv)potassium carbonate and (0.05 equiv) Pd(PPh3)4 were also added.The reaction was stirred at 110C for the desired time. After completion of the reaction, 10 mL of water was added, and then extracted with dichloromethane (3 10 mL), the organic layers were combined and dried using magnesium sulfate, and the solvent was evaporated under reduced pressure. The obtained material was purified on silica gel by column chromatography (CH2Cl2/PE: 90/10)to afford compounds 8-12. 2,4-Dichloro-6-(4-methoxyphenyl)pyrido[2,3-d]pyrimidine (8) (C14H9Cl2N3O): Compound 8 was obtained from 2,4,6-trichloropyrido[2,3-d]pyrimidine 6 using 4-methoxyphenyl boronic acid (1.05 equiv), as a white solid in 83%yield.
  • 15
  • [ 1234616-70-6 ]
  • [ 5720-07-0 ]
  • C21H16ClN3O2 [ No CAS ]
  • C14H9BrClN3O [ No CAS ]
YieldReaction ConditionsOperation in experiment
36%; 7% With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In toluene; at 110.0℃; for 3.0h; General procedure: To an argon degassed solution of 6-halogeno-2,4-dichloropyrido[2,3-d]pyrimidine 6 or 7 (0.5 mmol) in toluene (6mL) the desired (Het)aryl boronic acid was added then (1.5 equiv)potassium carbonate and (0.05 equiv) Pd(PPh3)4 were also added.The reaction was stirred at 110C for the desired time. After completion of the reaction, 10 mL of water was added, and then extracted with dichloromethane (3 10 mL), the organic layers were combined and dried using magnesium sulfate, and the solvent was evaporated under reduced pressure. The obtained material was purified on silica gel by column chromatography (CH2Cl2/PE: 90/10)to afford compounds 8-12. 2,4-Dichloro-6-(4-methoxyphenyl)pyrido[2,3-d]pyrimidine (8) (C14H9Cl2N3O): Compound 8 was obtained from 2,4,6-trichloropyrido[2,3-d]pyrimidine 6 using 4-methoxyphenyl boronic acid (1.05 equiv), as a white solid in 83%yield.
Recommend Products
Same Skeleton Products

Technical Information

Historical Records
; ;